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    Mxd4 Max dimerization protein 4 [ Mus musculus (house mouse) ]

    Gene ID: 17122, updated on 2-Apr-2024

    Summary

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    Official Symbol
    Mxd4provided by MGI
    Official Full Name
    Max dimerization protein 4provided by MGI
    Primary source
    MGI:MGI:104991
    See related
    Ensembl:ENSMUSG00000037235 AllianceGenome:MGI:104991
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mad4; bHLHc12; 2810410A03Rik
    Summary
    Contributes to DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II. Acts upstream of or within negative regulation of transcription, DNA-templated. Part of RNA polymerase II transcription regulator complex. Is expressed in several structures, including craniocervical region bone; limb mesenchyme; neural tube; skin; and thymus. Orthologous to human MXD4 (MAX dimerization protein 4). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in ovary adult (RPKM 161.0), thymus adult (RPKM 147.7) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    5 B2; 5 17.84 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (34331231..34345076, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (34176580..34187710, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene DNA polymerase N Neighboring gene RIKEN cDNA 4930557J02 gene Neighboring gene STARR-positive B cell enhancer ABC_E1299 Neighboring gene STARR-seq mESC enhancer starr_12836 Neighboring gene predicted gene, 25918 Neighboring gene HAUS augmin-like complex, subunit 3 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:34530746-34530855 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:34537815-34537924 Neighboring gene zinc finger, FYVE domain containing 28 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:34575558-34575759 Neighboring gene cilia and flagella associated protein 99 Neighboring gene predicted gene 5553

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The transcription factor Mxd4 controls the proliferation of the first blood precursors at the onset of hematopoietic development in vitro. Boros K, et al. Exp Hematol, 2011 Nov. PMID 21782766
    2. Mad4 is regulated by a transcriptional repressor complex that contains Miz-1 and c-Myc. Kime L, et al. Biochem J, 2003 Feb 15. PMID 12418961, Free PMC Article
    3. OX40 engagement stabilizes Mxd4 and Mnt protein levels in antigen-stimulated T cells leading to an increase in cell survival. Vasilevsky NA, et al. Eur J Immunol, 2011 Apr. PMID 21400495, Free PMC Article
    4. Sequential expression of the MAD family of transcriptional repressors during differentiation and development. Quéva C, et al. Oncogene, 1998 Feb 26. PMID 9519870
    5. Mad3 and Mad4: novel Max-interacting transcriptional repressors that suppress c-myc dependent transformation and are expressed during neural and epidermal differentiation. Hurlin PJ, et al. EMBO J, 1996 Apr 15. PMID 8617250, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. during embryonic hematopoietic differentiation Mxd4 is an important player in the regulation of blood progenitor proliferation, and downregulation of its expression might be required for a proliferative burst preceding lineage specification.
      Title: The transcription factor Mxd4 controls the proliferation of the first blood precursors at the onset of hematopoietic development in vitro.
    2. Mxd4 and Mnt upregulation following OX40 engagement most likely increases T-cell survival
      Title: OX40 engagement stabilizes Mxd4 and Mnt protein levels in antigen-stimulated T cells leading to an increase in cell survival.
    3. regulation by a transcriptional repressor complex that contains Miz-1 and c-Myc
      Title: Mad4 is regulated by a transcriptional repressor complex that contains Miz-1 and c-Myc.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    contributes_to DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    contributes_to DNA-binding transcription repressor activity, RNA polymerase II-specific IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to RNA polymerase II transcription regulatory region sequence-specific DNA binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within negative regulation of DNA-templated transcription IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of RNA polymerase II transcription regulator complex IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    max dimerization protein 4
    Names
    max dimerizer 4
    max-associated protein 4
    max-interacting transcriptional repressor MAD4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010753.3 → NP_034883.2  max dimerization protein 4

      See identical proteins and their annotated locations for NP_034883.2

      Status: VALIDATED

      Source sequence(s)
      AC157989
      Consensus CDS
      CCDS19212.1
      UniProtKB/TrEMBL
      Q91VN7, Q9D8P5
      Related
      ENSMUSP00000039071.7, ENSMUST00000042701.13
      Conserved Domains (1) summary
      cd18929
      Location:53 → 140
      bHLHzip_Mad4; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in Max-associated protein 4 (Mad4) and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      34331231..34345076 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q60948.1 GenPept UniProtKB/Swiss-Prot:Q60948

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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