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    Mgst2 microsomal glutathione S-transferase 2 [ Mus musculus (house mouse) ]

    Gene ID: 211666, updated on 23-Jun-2021

    Summary

    Official Symbol
    Mgst2provided by MGI
    Official Full Name
    microsomal glutathione S-transferase 2provided by MGI
    Primary source
    MGI:MGI:2448481
    See related
    Ensembl:ENSMUSG00000074604
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    GST; GST2; MGST; MGST-II
    Expression
    Broad expression in large intestine adult (RPKM 4.2), bladder adult (RPKM 2.7) and 15 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Mgst2 in Genome Data Viewer
    Location:
    3; 3 C
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (51544179..51590096)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (51636912..51682675)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 3 NC_000069.5 (51465115..51486597)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 36008 Neighboring gene RIKEN cDNA 5031434O11 gene Neighboring gene SET domain containing (lysine methyltransferase) 7 Neighboring gene predicted gene, 38247 Neighboring gene VISTA enhancer mm1010 Neighboring gene mastermind like transcriptional coactivator 3 Neighboring gene predicted gene, 46803

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1)  1 citation
    • Endonuclease-mediated (1) 

    General gene information

    Markers

    Homology

    Clone Names

    • MGC41409

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables enzyme activator activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables glutathione binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables glutathione peroxidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables glutathione peroxidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables glutathione transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables glutathione transferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables leukotriene-C4 synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables leukotriene-C4 synthase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in glutathione biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in leukotriene biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in leukotriene biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in leukotriene metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in lipid metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in membrane lipid catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nuclear envelope IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    microsomal glutathione S-transferase 2
    Names
    glutathione peroxidase MGST2
    leukotriene C4 synthase MGST2
    microsomal GST-2
    microsomal GST-II
    microsomal glutathione S-transferase II
    NP_001297411.1
    NP_778160.2
    XP_006501311.1
    XP_011238358.1
    XP_011238359.1
    XP_030108387.1
    XP_030108388.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001310482.1NP_001297411.1  microsomal glutathione S-transferase 2 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate exon in the 3' coding region, resulting in a frameshift and an early stop codon compared to variant 1. The encoded isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AI005961, BC145529, EH107642
      Consensus CDS
      CCDS79903.1
      UniProtKB/TrEMBL
      A0A0A6YWX7
      Related
      ENSMUSP00000141745.2, ENSMUST00000159554.7
      Conserved Domains (1) summary
      pfam01124
      Location:872
      MAPEG; MAPEG family
    2. NM_174995.3NP_778160.2  microsomal glutathione S-transferase 2 isoform 1

      See identical proteins and their annotated locations for NP_778160.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AA794266, AI005961, AV064608, EH107642
      Consensus CDS
      CCDS38428.1
      UniProtKB/TrEMBL
      A2RST1
      Related
      ENSMUSP00000096705.4, ENSMUST00000099106.10
      Conserved Domains (1) summary
      pfam01124
      Location:8124
      MAPEG; MAPEG family

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      51544179..51590096
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030252528.2XP_030108388.1  microsomal glutathione S-transferase 2 isoform X2

    2. XM_006501248.1XP_006501311.1  microsomal glutathione S-transferase 2 isoform X2

      See identical proteins and their annotated locations for XP_006501311.1

    3. XM_011240056.4XP_011238358.1  microsomal glutathione S-transferase 2 isoform X1

    4. XM_030252527.2XP_030108387.1  microsomal glutathione S-transferase 2 isoform X2

    5. XM_011240057.4XP_011238359.1  microsomal glutathione S-transferase 2 isoform X2

      See identical proteins and their annotated locations for XP_011238359.1

      Conserved Domains (1) summary
      pfam01124
      Location:158
      MAPEG; MAPEG family
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