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    Ralgapa2 Ral GTPase activating protein, alpha subunit 2 (catalytic) [ Mus musculus (house mouse) ]

    Gene ID: 241694, updated on 3-Apr-2024

    Summary

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    Official Symbol
    Ralgapa2provided by MGI
    Official Full Name
    Ral GTPase activating protein, alpha subunit 2 (catalytic)provided by MGI
    Primary source
    MGI:MGI:3036245
    See related
    Ensembl:ENSMUSG00000037110 AllianceGenome:MGI:3036245
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    P220; RGC2; AS250; pp250; A230067G21Rik
    Summary
    Enables GTPase activator activity. Acts upstream of or within several processes, including Ral protein signal transduction; activation of GTPase activity; and regulation of exocyst localization. Predicted to be located in cytosol and plasma membrane. Predicted to be active in cytoplasm. Is expressed in cochlea; diencephalon lateral wall ventricular layer; midbrain ventricular layer; olfactory cortex mantle layer; and olfactory epithelium. Orthologous to human RALGAPA2 (Ral GTPase activating protein catalytic subunit alpha 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in heart adult (RPKM 4.9), subcutaneous fat pad adult (RPKM 4.2) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    2 G1; 2 71.33 cM
    Exon count:
    49
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (146079326..146354174, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (146239876..146512254, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene cilia and flagella associated protein 61 Neighboring gene STARR-seq mESC enhancer starr_05936 Neighboring gene predicted gene, 34629 Neighboring gene RIKEN cDNA A930019D19 gene Neighboring gene insulinoma-associated 1 Neighboring gene STARR-seq mESC enhancer starr_05939 Neighboring gene ATP synthase mitochondrial F1 complex assembly factor 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_05941 Neighboring gene STARR-positive B cell enhancer ABC_E4508 Neighboring gene RIKEN cDNA 4933406D12 gene Neighboring gene STARR-seq mESC enhancer starr_05944 Neighboring gene STARR-seq mESC enhancer starr_05945 Neighboring gene predicted gene, 52577

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Down-regulation of RalGTPase-Activating Protein Promotes Colitis-Associated Cancer via NLRP3 Inflammasome Activation. Iida T, et al. Cell Mol Gastroenterol Hepatol, 2020. PMID 31622786, Free PMC Article
    2. Downregulation of Ral GTPase-activating protein promotes tumor invasion and metastasis of bladder cancer. Saito R, et al. Oncogene, 2013 Feb 14. PMID 22450745
    3. Novel insulin-elicited phosphoproteins in adipocytes. Gridley S, et al. Cell Signal, 2005 Jan. PMID 15451025
    4. Downregulation of RalGTPase-activating protein promotes invasion of prostatic epithelial cells and progression from intraepithelial neoplasia to cancer during prostate carcinogenesis. Uegaki M, et al. Carcinogenesis, 2019 Dec 31. PMID 31058283
    5. Adipocytes contain a novel complex similar to the tuberous sclerosis complex. Gridley S, et al. Cell Signal, 2006 Oct. PMID 16490346

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Down-regulation of RalGTPase-Activating Protein Promotes Colitis-Associated Cancer via NLRP3 Inflammasome Activation.
      Title: Down-regulation of RalGTPase-Activating Protein Promotes Colitis-Associated Cancer via NLRP3 Inflammasome Activation.
    2. loss of RalGAP function has a distinct role in promoting progression from prostatic intraepithelial neoplasia to invasive adenocarcinoma.
      Title: Downregulation of RalGTPase-activating protein promotes invasion of prostatic epithelial cells and progression from intraepithelial neoplasia to cancer during prostate carcinogenesis.
    3. study reports the identification and characterization of a Ral GAP complex (RG1, RGC2) that mediates the activation of RalA downstream of the PI 3-kinase/Akt pathway
      Title: A Ral GAP complex links PI 3-kinase/Akt signaling to RalA activation in insulin action.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1)  1 citation
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA1272

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activator activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables GTPase activator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within Ral protein signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within activation of GTPase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of exocyst localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of protein localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of small GTPase mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ral GTPase-activating protein subunit alpha-2
    Names
    250 kDa substrate of Akt
    ral GTPase-activating protein alpha subunit 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033348.4 → NP_001028520.2  ral GTPase-activating protein subunit alpha-2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL845273, AL845430, AL935056
      Consensus CDS
      CCDS16831.2
      UniProtKB/Swiss-Prot
      A3KGS3, A3KGS5, B7ZCU9, Q3TZD9, Q4VA60, Q69ZM8, Q7TQL4, Q8BYP2
      UniProtKB/TrEMBL
      A0A0A0MQD7
      Related
      ENSMUSP00000105613.3, ENSMUST00000109986.9
      Conserved Domains (1) summary
      pfam02145
      Location:1702 → 1874
      Rap_GAP; Rap/ran-GAP

    2. NM_001408200.1 → NP_001395129.1  ral GTPase-activating protein subunit alpha-2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL845273, AL845430, AL935056
      Related
      ENSMUSP00000122039.2, ENSMUST00000131824.8

    3. NM_001408201.1 → NP_001395130.1  ral GTPase-activating protein subunit alpha-2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL845273, AL845430, AL935056
      UniProtKB/TrEMBL
      A0A2I3BPN8
      Related
      ENSMUSP00000153734.2, ENSMUST00000228797.2

    4. NM_001408202.1 → NP_001395131.1  ral GTPase-activating protein subunit alpha-2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL845273, AL845430
      Related
      ENSMUST00000109982.9

    RNA

    1. NR_176472.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL935056

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      146079326..146354174 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036161998.1 → XP_036017891.1  ral GTPase-activating protein subunit alpha-2 isoform X3

      Conserved Domains (1) summary
      pfam02145
      Location:852 → 1024
      Rap_GAP; Rap/ran-GAP

    RNA

    1. XR_374469.4 RNA Sequence

    2. XR_374468.4 RNA Sequence

    3. XR_003952992.2 RNA Sequence

    4. XR_004940347.1 RNA Sequence

    5. XR_004940346.1 RNA Sequence

    6. XR_866276.3 RNA Sequence

    7. XR_866277.4 RNA Sequence

    8. XR_866275.4 RNA Sequence

    9. XR_003952993.1 RNA Sequence

    10. XR_001782599.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A3KGS3.2 GenPept UniProtKB/Swiss-Prot:A3KGS3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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