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    Fndc1 fibronectin type III domain containing 1 [ Mus musculus (house mouse) ]

    Gene ID: 68655, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Fndc1provided by MGI
    Official Full Name
    fibronectin type III domain containing 1provided by MGI
    Primary source
    MGI:MGI:1915905
    See related
    Ensembl:ENSMUSG00000071984 AllianceGenome:MGI:1915905
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mKIAA1866; 1110027O12Rik; 1110051A18Rik
    Summary
    Predicted to act upstream of or within several processes, including cellular response to hypoxia; positive regulation of cardiac muscle cell apoptotic process; and positive regulation of protein phosphorylation. Predicted to be located in several cellular components, including cell-cell junction; mitochondrial membrane; and nuclear speck. Is expressed in alimentary system; dermis; embryo mesenchyme; and eye. Orthologous to human FNDC1 (fibronectin type III domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in bladder adult (RPKM 10.6), limb E14.5 (RPKM 9.5) and 15 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    17 A1; 17 4.77 cM
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (7957401..8046158, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (7738569..7827340, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 33086 Neighboring gene predicted gene, 33158 Neighboring gene STARR-seq mESC enhancer starr_41759 Neighboring gene adaptor-related protein complex 3, sigma 1 subunit pseudogene Neighboring gene expressed sequence AU041480 Neighboring gene predicted gene 1604A Neighboring gene T cell activation Rho GTPase activating protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Activator of G protein signaling 8 (AGS8) is required for hypoxia-induced apoptosis of cardiomyocytes: role of G betagamma and connexin 43 (CX43). Sato M, et al. J Biol Chem, 2009 Nov 6. PMID 19723622, Free PMC Article
    2. The Rodent-Specific MicroRNA Cluster within the Sfmbt2 Gene Is Imprinted and Essential for Placental Development. Inoue K, et al. Cell Rep, 2017 May 2. PMID 28467908
    3. Genomic variants in an inbred mouse model predict mania-like behaviors. Saul MC, et al. PLoS One, 2018. PMID 29768498, Free PMC Article
    4. A large-scale in situ screen provides molecular evidence for the induction of eye anterior segment structures by the developing lens. Thut CJ, et al. Dev Biol, 2001 Mar 1. PMID 11180952
    5. Understanding the development of oral epithelial organs through single cell transcriptomic analysis. Ye Q, et al. Development, 2022 Aug 15. PMID 35831953, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Spontaneous (1)  1 citation
    • Targeted (1) 
    • Endonuclease-mediated (5) 

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA1866

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cellular response to hypoxia ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of cardiac muscle cell apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of protein transport ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell-cell junction ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    located_in mitochondrial membrane ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    fibronectin type III domain-containing protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081416.3 → NP_001074885.2  fibronectin type III domain-containing protein 1 isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AC164983
      Consensus CDS
      CCDS37431.1
      UniProtKB/TrEMBL
      A0A8V5KYN9, E9Q043
      Related
      ENSMUSP00000159498.1, ENSMUST00000240702.1
      Conserved Domains (3) summary
      smart00060
      Location:103 → 186
      FN3; Fibronectin type 3 domain
      PHA03247
      Location:584 → 1157
      PHA03247; large tegument protein UL36; Provisional
      cd00063
      Location:307 → 397
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

    2. NM_001403750.1 → NP_001390679.1  fibronectin type III domain-containing protein 1 isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      AC164983
      UniProtKB/TrEMBL
      A0A6I8MWX0
      Related
      ENSMUSP00000159298.2, ENSMUST00000239425.2

    3. NM_001403751.1 → NP_001390680.1  fibronectin type III domain-containing protein 1 isoform 3 precursor

      Status: VALIDATED

      Source sequence(s)
      AC164983

    4. NM_001403752.1 → NP_001390681.1  fibronectin type III domain-containing protein 1 isoform 4 precursor

      Status: VALIDATED

      Source sequence(s)
      AC164983

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      7957401..8046158 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036160769.1 → XP_036016662.1  fibronectin type III domain-containing protein 1 isoform X3

      UniProtKB/TrEMBL
      E9Q043
      Conserved Domains (3) summary
      smart00060
      Location:37 → 117
      FN3; Fibronectin type 3 domain
      PHA03247
      Location:573 → 1146
      PHA03247; large tegument protein UL36; Provisional
      cd00063
      Location:1534 → 1625
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

    2. XM_006523350.5 → XP_006523413.1  fibronectin type III domain-containing protein 1 isoform X2

      UniProtKB/TrEMBL
      E9Q043
      Conserved Domains (3) summary
      smart00060
      Location:37 → 117
      FN3; Fibronectin type 3 domain
      PHA03247
      Location:613 → 1186
      PHA03247; large tegument protein UL36; Provisional
      cd00063
      Location:336 → 426
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

    RNA

    1. XR_385179.5 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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