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    Il18 interleukin 18 [ Mus musculus (house mouse) ]

    Gene ID: 16173, updated on 28-Jun-2021

    Summary

    Official Symbol
    Il18provided by MGI
    Official Full Name
    interleukin 18provided by MGI
    Primary source
    MGI:MGI:107936
    See related
    Ensembl:ENSMUSG00000039217
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ig; Il-; Igif; Il-18
    Expression
    Ubiquitous expression in colon adult (RPKM 9.4), cortex adult (RPKM 6.9) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Il18 in Genome Data Viewer
    Location:
    9 A5.3; 9 27.75 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (50466000..50493141)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (50554700..50581841)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (50373473..50389942)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene placenta expressed transcript 1, opposite strand Neighboring gene placenta expressed transcript 1 Neighboring gene 6-pyruvoyl-tetrahydropterin synthase Neighboring gene beta-carotene oxygenase 2 Neighboring gene testis expressed 12 Neighboring gene succinate dehydrogenase complex, subunit D, integral membrane protein Neighboring gene translocase of inner mitochondrial membrane 8B Neighboring gene NKAP domain containing 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cytokine activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables cytokine activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables cytokine activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables interleukin-18 receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within T-helper 1 cell cytokine production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within T-helper 1 cell cytokine production IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in T-helper 1 type immune response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in T-helper 1 type immune response ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in activation of protein kinase B activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in angiogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    acts_upstream_of_or_within cell population proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within cell population proliferation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in cellular response to organic cyclic compound ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to peptide hormone stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cholesterol homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in detection of mechanical stimulus involved in sensory perception of pain ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in extrinsic apoptotic signaling pathway via death domain receptors TAS
    Traceable Author Statement
    more info
    PubMed 
    acts_upstream_of_or_within immune response TAS
    Traceable Author Statement
    more info
    PubMed 
    acts_upstream_of_or_within inflammatory response IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in inflammatory response ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within interleukin-18-mediated signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in interleukin-18-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within interleukin-6 production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in lipopolysaccharide-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within natural killer cell activation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within natural killer cell mediated cytotoxicity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of myoblast differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of neutrophil apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of peptidyl-tyrosine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within neutrophil activation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of NF-kappaB transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of NIK/NF-kappaB signaling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of NK T cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of T-helper 1 cell cytokine production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of T-helper 2 cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of activated T cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of activated T cell proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of blood vessel remodeling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of chemokine production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cold-induced thermogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of collagen biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of granulocyte macrophage colony-stimulating factor production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of hepatocyte proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of interferon-gamma production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of interferon-gamma production IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of interferon-gamma production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of interferon-gamma production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of interleukin-13 production TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of interleukin-17 production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of interleukin-8 production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of macrophage derived foam cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of male germ cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of natural killer cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of neuron apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of phosphatidylinositol 3-kinase signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein kinase B signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of smooth muscle cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of smooth muscle cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of superoxide anion generation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of tumor necrosis factor production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of tyrosine phosphorylation of STAT protein ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of vascular permeability ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cell adhesion ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in response to hypoxia ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in sleep ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in sleep ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in triglyceride homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    interleukin-18
    Names
    IFN-gamma-inducing factor
    IL-1 gamma
    interferon gamma-inducing factor
    interleukin-1 gamma

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357221.1NP_001344150.1  interleukin-18 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same isoform (a).
      Source sequence(s)
      AC025500, AC127254
      Consensus CDS
      CCDS40622.1
      Related
      ENSMUSP00000151002.2, ENSMUST00000214117.2
      Conserved Domains (1) summary
      cl00094
      Location:76182
      IL1; Interleukin-1 homologes; Cytokines with various biological functions. Interleukin 1 alpha and beta are also known as hematopoietin and catabolin. This family also contains interleukin-1 receptor antagonists (inhibitors).
    2. NM_001357222.1NP_001344151.1  interleukin-18 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and lacks an alternate coding exon in the 3' end compared to variant 1, that causes a frameshift. The resulting isoform (b) has a shorter and distinct C-terminus compared to isoform a.
      Source sequence(s)
      AC025500, AC127254, AV328761
      Consensus CDS
      CCDS90562.1
      Related
      ENSMUSP00000150305.2, ENSMUST00000213916.2
    3. NM_008360.2NP_032386.1  interleukin-18 isoform a

      See identical proteins and their annotated locations for NP_032386.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1 and 2 both encode the same isoform (a).
      Source sequence(s)
      AC025500, AC127254, CX123286
      Consensus CDS
      CCDS40622.1
      UniProtKB/Swiss-Prot
      P70380
      UniProtKB/TrEMBL
      Q2PMY2
      Conserved Domains (1) summary
      cl00094
      Location:76182
      IL1; Interleukin-1 homologes; Cytokines with various biological functions. Interleukin 1 alpha and beta are also known as hematopoietin and catabolin. This family also contains interleukin-1 receptor antagonists (inhibitors).

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      50466000..50493141
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006510024.1XP_006510087.1  interleukin-18 isoform X2

      Conserved Domains (1) summary
      cl00094
      Location:96202
      IL1; Interleukin-1 homologes; Cytokines with various biological functions. Interleukin 1 alpha and beta are also known as hematopoietin and catabolin. This family also contains interleukin-1 receptor antagonists (inhibitors).
    2. XM_036154618.1XP_036010511.1  interleukin-18 isoform X4

      Conserved Domains (1) summary
      cl00094
      Location:60166
      IL1; Interleukin-1 homologes; Cytokines with various biological functions. Interleukin 1 alpha and beta are also known as hematopoietin and catabolin. This family also contains interleukin-1 receptor antagonists (inhibitors).
    3. XM_036154619.1XP_036010512.1  interleukin-18 isoform X4

      Conserved Domains (1) summary
      cl00094
      Location:60166
      IL1; Interleukin-1 homologes; Cytokines with various biological functions. Interleukin 1 alpha and beta are also known as hematopoietin and catabolin. This family also contains interleukin-1 receptor antagonists (inhibitors).
    4. XM_036154616.1XP_036010509.1  interleukin-18 isoform X2

      Conserved Domains (1) summary
      cl00094
      Location:96202
      IL1; Interleukin-1 homologes; Cytokines with various biological functions. Interleukin 1 alpha and beta are also known as hematopoietin and catabolin. This family also contains interleukin-1 receptor antagonists (inhibitors).
    5. XM_030244066.2XP_030099926.1  interleukin-18 isoform X2

      Conserved Domains (1) summary
      cl00094
      Location:96202
      IL1; Interleukin-1 homologes; Cytokines with various biological functions. Interleukin 1 alpha and beta are also known as hematopoietin and catabolin. This family also contains interleukin-1 receptor antagonists (inhibitors).
    6. XM_036154615.1XP_036010508.1  interleukin-18 isoform X1

      Conserved Domains (1) summary
      cl00094
      Location:157263
      IL1; Interleukin-1 homologes; Cytokines with various biological functions. Interleukin 1 alpha and beta are also known as hematopoietin and catabolin. This family also contains interleukin-1 receptor antagonists (inhibitors).
    7. XM_017313137.3XP_017168626.1  interleukin-18 isoform X1

      Conserved Domains (1) summary
      cl00094
      Location:157263
      IL1; Interleukin-1 homologes; Cytokines with various biological functions. Interleukin 1 alpha and beta are also known as hematopoietin and catabolin. This family also contains interleukin-1 receptor antagonists (inhibitors).
    8. XM_036154617.1XP_036010510.1  interleukin-18 isoform X3

      Conserved Domains (1) summary
      cl00094
      Location:76182
      IL1; Interleukin-1 homologes; Cytokines with various biological functions. Interleukin 1 alpha and beta are also known as hematopoietin and catabolin. This family also contains interleukin-1 receptor antagonists (inhibitors).
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