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    Tmem255a transmembrane protein 255A [ Mus musculus (house mouse) ]

    Gene ID: 245386, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Tmem255aprovided by MGI
    Official Full Name
    transmembrane protein 255Aprovided by MGI
    Primary source
    MGI:MGI:3045722
    See related
    Ensembl:ENSMUSG00000036502 AllianceGenome:MGI:3045722
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Fam70a; 4933417N17; 6430550H21Rik
    Summary
    Acts upstream of or within response to bacterium. Predicted to be located in membrane. Predicted to be integral component of membrane. Is expressed in several structures, including genitourinary system. Orthologous to human TMEM255A (transmembrane protein 255A). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in cerebellum adult (RPKM 10.3), frontal lobe adult (RPKM 9.9) and 22 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tmem255a in Genome Data Viewer
    Location:
    X A3.3; X 22.46 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (37285450..37341373, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (38196573..38252496, complement)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 39506 Neighboring gene reproductive homeobox 13 Neighboring gene STARR-seq mESC enhancer starr_47013 Neighboring gene STARR-seq mESC enhancer starr_47014 Neighboring gene zinc finger protein 36, C3H type-like 1, pseudogene Neighboring gene zinc finger and BTB domain containing 33 Neighboring gene STARR-seq mESC enhancer starr_47015 Neighboring gene microRNA 3110 Neighboring gene predicted gene, 39507 Neighboring gene arylsulfatase K pseudogene Neighboring gene reproductive homeobox 7, pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Fam70A binds Wnt5a to regulate meiosis and quality of mouse oocytes. Zhang NN, et al. Cell Prolif, 2020 Jun. PMID 32391621, Free PMC Article
    2. Functional redundancy of frizzled 3 and frizzled 6 in planar cell polarity control of mouse hair follicles. Dong B, et al. Development, 2018 Oct 8. PMID 30237242, Free PMC Article
    3. Genome-wide identification of endothelial cell-enriched genes in the mouse embryo. Takase H, et al. Blood, 2012 Jul 26. PMID 22535667
    4. Genomewide discovery and classification of candidate ovarian fertility genes in the mouse. Gallardo TD, et al. Genetics, 2007 Sep. PMID 17660561, Free PMC Article
    5. Placental PPARγ regulates spatiotemporally diverse genes and a unique metabolic network. Shalom-Barak T, et al. Dev Biol, 2012 Dec 1. PMID 22967998, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Fam70A regulates meiosis and quality of mouse oocytes through both canonical and non-canonical Wnt5a signalling pathways.
      Title: Fam70A binds Wnt5a to regulate meiosis and quality of mouse oocytes.
    2. Transcripts highly enriched in ovary; gene identified as candidate female fertility factor.
      Title: Genomewide discovery and classification of candidate ovarian fertility genes in the mouse.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within response to bacterium IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    transmembrane protein 255A
    Names
    family with sequence similarity 70, member A
    protein FAM70A

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001289727.1 → NP_001276656.1  transmembrane protein 255A isoform 2

      See identical proteins and their annotated locations for NP_001276656.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) includes an alternate 3' terminal exon, which causes a frameshift, compared to variant 1. This results in a shorter protein (isoform 2) that has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AK041985, AL512346, BY085502
      Consensus CDS
      CCDS81122.1
      UniProtKB/Swiss-Prot
      Q8BHW5
      Related
      ENSMUSP00000086457.4, ENSMUST00000089056.10
      Conserved Domains (2) summary
      pfam13273
      Location:30 → 105
      DUF4064; Protein of unknown function (DUF4064)
      pfam14967
      Location:9 → 297
      FAM70; FAM70 protein

    2. NM_001289728.1 → NP_001276657.1  transmembrane protein 255A isoform 3

      See identical proteins and their annotated locations for NP_001276657.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon, compared to variant 1. This results in a shorter isoform (3), compared to isoform 1.
      Source sequence(s)
      AK045375, AK078264, AV362114, BC062956, BY085502
      Consensus CDS
      CCDS72367.1
      UniProtKB/Swiss-Prot
      Q8BHW5
      UniProtKB/TrEMBL
      Q8BHS0
      Related
      ENSMUSP00000086455.5, ENSMUST00000089054.11
      Conserved Domains (1) summary
      pfam14967
      Location:7 → 327
      FAM70; FAM70 protein

    3. NM_172930.4 → NP_766518.3  transmembrane protein 255A isoform 1

      See identical proteins and their annotated locations for NP_766518.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AK045375, AV362114, BC062956, BY085502
      Consensus CDS
      CCDS30089.1
      UniProtKB/Swiss-Prot
      Q6P5C9, Q8BHV8, Q8BHW5, Q8BHZ6
      Related
      ENSMUSP00000064511.8, ENSMUST00000066498.8
      Conserved Domains (1) summary
      pfam14967
      Location:9 → 350
      FAM70; FAM70 protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      37285450..37341373 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006541495.4 → XP_006541558.1  transmembrane protein 255A isoform X1

      Related
      ENSMUST00000155848.8
      Conserved Domains (1) summary
      pfam14967
      Location:7 → 303
      FAM70; FAM70 protein
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BHW5.1 GenPept UniProtKB/Swiss-Prot:Q8BHW5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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