Mtdh metadherin [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mtdhprovided by MGI
Official Full Name: metadherinprovided by MGI
Primary source: MGI:MGI:1914404
See related: Ensembl:ENSMUSG00000022255 AllianceGenome:MGI:1914404
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 3D3; AEG-1; Lyric; 3D3/Lyric; D8Bwg1112e; 2610103J23Rik
Summary: Predicted to enable NF-kappaB binding activity; double-stranded RNA binding activity; and transcription coactivator activity. Predicted to be involved in several processes, including lipopolysaccharide-mediated signaling pathway; positive regulation of intracellular signal transduction; and regulation of transcription, DNA-templated. Located in endoplasmic reticulum membrane; nucleolus; and perinuclear region of cytoplasm. Is expressed in several structures, including brain; genitourinary system; limb primordium; nose; and skin. Human ortholog(s) of this gene implicated in hepatocellular carcinoma. Orthologous to human MTDH (metadherin). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 15.3), bladder adult (RPKM 13.4) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15 B3.1; 15 13.98 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (34082613..34143683)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (34082442..34143537)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Inhibition of Granule Cell Dispersion and Seizure Development by Astrocyte Elevated Gene-1 in a Mouse Model of Temporal Lobe Epilepsy.
Title: Inhibition of Granule Cell Dispersion and Seizure Development by Astrocyte Elevated Gene-1 in a Mouse Model of Temporal Lobe Epilepsy.
Metadherin orchestrates PKA and PKM2 to activate beta-catenin signaling in podocytes during proteinuric chronic kidney disease.
Title: Metadherin orchestrates PKA and PKM2 to activate β-catenin signaling in podocytes during proteinuric chronic kidney disease.
Expression patterns of AEG-1 in the normal brain.
Title: Expression patterns of AEG-1 in the normal brain.
Astrocyte Elevated Gene-1 Cys75 S-Palmitoylation by ZDHHC6 Regulates Its Biological Activity.
Title: Astrocyte Elevated Gene-1 Cys75 S-Palmitoylation by ZDHHC6 Regulates Its Biological Activity.
Dissecting the Balance Between Metabolic and Oncogenic Functions of Astrocyte-Elevated Gene-1/Metadherin.
Title: Dissecting the Balance Between Metabolic and Oncogenic Functions of Astrocyte-Elevated Gene-1/Metadherin.
Small-molecule inhibitors that disrupt the MTDH-SND1 complex suppress breast cancer progression and metastasis.
Title: Small-molecule inhibitors that disrupt the MTDH-SND1 complex suppress breast cancer progression and metastasis.
The Scope of Astrocyte Elevated Gene-1/Metadherin (AEG-1/MTDH) in Cancer Clinicopathology: A Review.
Title: The Scope of Astrocyte Elevated Gene-1/Metadherin (AEG-1/MTDH) in Cancer Clinicopathology: A Review.
A novel metadherinDelta7 splice variant enhances triple negative breast cancer aggressiveness by modulating mitochondrial function via NFkB-SIRT3 axis.
Title: A novel metadherinΔ7 splice variant enhances triple negative breast cancer aggressiveness by modulating mitochondrial function via NFĸB-SIRT3 axis.
Investigated the therapeutic efficacy of micheliolide (MCL) on renal fibrosis in vivo and in vitro and further investigate the underlying mechanism of metadherin (Mtdh) as a target of MCL in this condition.
Title: Micheliolide ameliorates renal fibrosis by suppressing the Mtdh/BMP/MAPK pathway.
AEG-1 has a role in regulating macrophage activation; AEG-1 is required in both tumor cells and tumor microenvironment to stimulate hepatocarcinogenesis
Title: Astrocyte Elevated Gene-1 Regulates Macrophage Activation in Hepatocellular Carcinogenesis.

Submit: New GeneRIF Correction See all GeneRIFs (30)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (5) 1 citation
Endonuclease-mediated (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH131760 (e-PCR)
- UniSTS:215043

AV353288 (e-PCR)
- UniSTS:180744

RH125829 (e-PCR)
- UniSTS:162573

MTDH (e-PCR)
- UniSTS:504352

RH140727 (e-PCR)
- UniSTS:222793

Mtdh (e-PCR), detects polymorphism
- UniSTS:526938

RH124812 (e-PCR)
- UniSTS:161634

D8Bwg1112e (e-PCR), detects polymorphism
- UniSTS:142713

fl05f06.x1 (e-PCR)
- UniSTS:201902

D15Mit55 (e-PCR), detects polymorphism
- UniSTS:127674

RH135870 (e-PCR)
- UniSTS:209868

RH125179 (e-PCR)
- UniSTS:162001

NoName (e-PCR)
- UniSTS:237280

fk56e12.x1 (e-PCR)
- UniSTS:201209

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables NF-kappaB binding	IBA Inferred from Biological aspect of Ancestor more info
enables NF-kappaB binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II-specific DNA-binding transcription factor binding	ISO Inferred from Sequence Orthology more info
enables double-stranded RNA binding	ISO Inferred from Sequence Orthology more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription coactivator activity	ISO Inferred from Sequence Orthology more info
enables transcription coregulator activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in lipopolysaccharide-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of NF-kappaB transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of autophagy	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in anchoring junction	IEA Inferred from Electronic Annotation more info
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in bicellular tight junction	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	IDA Inferred from Direct Assay more info	PubMed
located_in fibrillar center	ISO Inferred from Sequence Orthology more info
located_in intercellular canaliculus	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nuclear body	ISO Inferred from Sequence Orthology more info
located_in nucleolus	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: protein LYRIC

Names: lysine-rich CEACAM1 co-isolated protein; metastasis adhesion protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001357925.1 → NP_001344854.1 protein LYRIC isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks exons in the coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.

Source sequence(s)

AC149588

Conserved Domains (1) summary

pfam15686
Location:6 → 386

LYRIC; Lysine-rich CEACAM1 co-isolated protein family
NM_001357926.1 → NP_001344855.1 protein LYRIC isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longest isoform (1).

Source sequence(s)

AC149588

Conserved Domains (1) summary

pfam15686
Location:6 → 449

LYRIC; Lysine-rich CEACAM1 co-isolated protein family
NM_026002.5 → NP_080278.3 protein LYRIC isoform 3

See identical proteins and their annotated locations for NP_080278.3

Status: VALIDATED

Description

Transcript Variant: This variant (3) lacks an exon in the coding region, compared to variant 1. The encoded isoform (3) is shorter, compared to isoform 1.

Source sequence(s)

AC149588

Consensus CDS

CCDS27415.1

UniProtKB/Swiss-Prot

B2RSG8, Q05CM0, Q3U9F8, Q3UAQ8, Q80WJ7, Q8BN67, Q8CBT9, Q8CDL0, Q8CGI7, Q9D052

Related

ENSMUSP00000022865.10, ENSMUST00000022865.17

Conserved Domains (1) summary

pfam15686
Location:6 → 419

LYRIC; Lysine-rich CEACAM1 co-isolated protein family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000081.7 Reference GRCm39 C57BL/6J

Range

34082613..34143683

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006520151.3 → XP_006520214.1 protein LYRIC isoform X2

Conserved Domains (1) summary

pfam15686
Location:6 → 449

LYRIC; Lysine-rich CEACAM1 co-isolated protein family
XM_017316729.3 → XP_017172218.1 protein LYRIC isoform X4

Conserved Domains (1) summary

pfam15686
Location:6 → 419

LYRIC; Lysine-rich CEACAM1 co-isolated protein family
XM_006520152.3 → XP_006520215.1 protein LYRIC isoform X7

UniProtKB/TrEMBL

F6QHD1

Related

ENSMUSP00000130190.3, ENSMUST00000163333.9

Conserved Domains (1) summary

pfam15686
Location:6 → 386

LYRIC; Lysine-rich CEACAM1 co-isolated protein family
XM_006520149.3 → XP_006520212.1 protein LYRIC isoform X1

Conserved Domains (1) summary

pfam15686
Location:6 → 390

LYRIC; Lysine-rich CEACAM1 co-isolated protein family
XM_017316731.3 → XP_017172220.1 protein LYRIC isoform X6

Conserved Domains (1) summary

pfam15686
Location:6 → 390

LYRIC; Lysine-rich CEACAM1 co-isolated protein family
XM_017316728.3 → XP_017172217.1 protein LYRIC isoform X3

Conserved Domains (1) summary

pfam15686
Location:6 → 360

LYRIC; Lysine-rich CEACAM1 co-isolated protein family
XM_017316730.3 → XP_017172219.1 protein LYRIC isoform X5

Conserved Domains (1) summary

pfam15686
Location:6 → 327

LYRIC; Lysine-rich CEACAM1 co-isolated protein family
XM_030248710.1 → XP_030104570.1 protein LYRIC isoform X8

UniProtKB/TrEMBL

F6ZSG0

Related

ENSMUSP00000131814.2, ENSMUST00000169905.2

Conserved Domains (1) summary

pfam15686
Location:12 → 208

LYRIC; Lysine-rich CEACAM1 co-isolated protein family
XM_036159548.1 → XP_036015441.1 protein LYRIC isoform X9

UniProtKB/TrEMBL

F6ZSG0

Conserved Domains (1) summary

pfam15686
Location:12 → 175

LYRIC; Lysine-rich CEACAM1 co-isolated protein family