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    Pld1 phospholipase D1 [ Mus musculus (house mouse) ]

    Gene ID: 18805, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Pld1provided by MGI
    Official Full Name
    phospholipase D1provided by MGI
    Primary source
    MGI:MGI:109585
    See related
    Ensembl:ENSMUSG00000027695 AllianceGenome:MGI:109585
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Pld1a; Pld1b; mPLD1
    Summary
    Predicted to enable phospholipase D activity. Acts upstream of or within defense response to Gram-positive bacterium. Predicted to be located in several cellular components, including Golgi cisterna; cytoplasmic vesicle; and lamellipodium. Predicted to be active in cholinergic synapse. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Human ortholog(s) of this gene implicated in developmental cardiac valvular defect. Orthologous to human PLD1 (phospholipase D1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in large intestine adult (RPKM 8.9), bladder adult (RPKM 4.5) and 25 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    3 A3; 3 11.15 cM
    Exon count:
    32
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (27992636..28187388)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (27938459..28133362)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_07251 Neighboring gene predicted gene, 42195 Neighboring gene predicted gene, 57707 Neighboring gene STARR-seq mESC enhancer starr_07254 Neighboring gene STARR-seq mESC enhancer starr_07256 Neighboring gene STARR-seq mESC enhancer starr_07258 Neighboring gene STARR-seq mESC enhancer starr_07259 Neighboring gene predicted gene, 42196 Neighboring gene predicted gene, 54170 Neighboring gene TRAF2 and NCK interacting kinase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Differential expression patterns of phospholipase D isoforms 1 and 2 in the mammalian brain and retina. Barber CN, et al. J Lipid Res, 2022 Aug. PMID 35764123, Free PMC Article
    2. PLD1 promotes tumor invasion by regulation of MMP-13 expression via NF-κB signaling in bladder cancer. Nagumo Y, et al. Cancer Lett, 2021 Jul 28. PMID 33945837
    3. Deletion of phospholipase D1 decreases bone mass and increases fat mass via modulation of Runx2, β-catenin-osteoprotegerin, PPAR-γ and C/EBPα signaling axis. Kang DW, et al. Biochim Biophys Acta Mol Basis Dis, 2021 May 1. PMID 33497821
    4. VU0155069 inhibits inflammasome activation independent of phospholipase D1 activity. Lee SK, et al. Sci Rep, 2019 Oct 4. PMID 31586128, Free PMC Article
    5. Phospholipase D1 regulation of TNF-alpha protects against responses to LPS. Urbahn MA, et al. Sci Rep, 2018 Jul 3. PMID 29968773, Free PMC Article

    See all (125) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Phospholipase D1 promotes astrocytic differentiation through the FAK/AURKA/STAT3 signaling pathway in hippocampal neural stem/progenitor cells.
      Title: Phospholipase D1 promotes astrocytic differentiation through the FAK/AURKA/STAT3 signaling pathway in hippocampal neural stem/progenitor cells.
    2. Differential expression patterns of phospholipase D isoforms 1 and 2 in the mammalian brain and retina.
      Title: Differential expression patterns of phospholipase D isoforms 1 and 2 in the mammalian brain and retina.
    3. RalA and PLD1 promote lipid droplet growth in response to nutrient withdrawal.
      Title: RalA and PLD1 promote lipid droplet growth in response to nutrient withdrawal.
    4. PLD1 promotes reactive oxygen species production in vascular smooth muscle cells and injury-induced neointima formation.
      Title: PLD1 promotes reactive oxygen species production in vascular smooth muscle cells and injury-induced neointima formation.
    5. PLD1 and PLD2 differentially regulate the balance of macrophage polarization in inflammation and tissue injury.
      Title: PLD1 and PLD2 differentially regulate the balance of macrophage polarization in inflammation and tissue injury.
    6. Deletion of phospholipase D1 decreases bone mass and increases fat mass via modulation of Runx2, beta-catenin-osteoprotegerin, PPAR-gamma and C/EBPalpha signaling axis.
      Title: Deletion of phospholipase D1 decreases bone mass and increases fat mass via modulation of Runx2, β-catenin-osteoprotegerin, PPAR-γ and C/EBPα signaling axis.
    7. Phospholipase D1 Ablation Disrupts Mouse Longitudinal Hippocampal Axis Organization and Functioning.
      Title: Phospholipase D1 Ablation Disrupts Mouse Longitudinal Hippocampal Axis Organization and Functioning.
    8. Phospholipase D1 and D2 Synergistically Regulate Thrombus Formation.
      Title: Phospholipase D1 and D2 Synergistically Regulate Thrombus Formation.
    9. Phospholipase D1 inhibition sensitizes glioblastoma to temozolomide and suppresses its tumorigenicity.
      Title: Phospholipase D1 inhibition sensitizes glioblastoma to temozolomide and suppresses its tumorigenicity.
    10. Suppressing aberrant phospholipase D1 signaling in 3xTg Alzheimer's disease mouse model promotes synaptic resilience.
      Title: Suppressing aberrant phospholipase D1 signaling in 3xTg Alzheimer's disease mouse model promotes synaptic resilience.
    Submit: New GeneRIF Correction See all GeneRIFs (66)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (9)  1 citation
    • Endonuclease-mediated (4) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables N-acylphosphatidylethanolamine-specific phospholipase D activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylinositol binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phospholipase D activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phospholipase D activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phospholipase D activity TAS
    Traceable Author Statement
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to nutrient ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within defense response to Gram-positive bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within lipid catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within phosphatidic acid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    acts_upstream_of_or_within phospholipid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in phospholipid catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phospholipid catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of translation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of microvillus assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of microvillus assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of synaptic vesicle cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to peptide hormone ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    located_in Golgi cisterna ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cholinergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endocytic vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in endosome ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in lamellipodium ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane region IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    phospholipase D1
    Names
    choline phosphatase 1
    phosphatidylcholine-hydrolyzing phospholipase D1
    NP_001157528.1
    NP_001355596.1
    NP_001397459.1
    NP_001397460.1
    NP_001397461.1
    NP_032901.2
    XP_017174978.1
    XP_017174979.1
    XP_017174980.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001164056.2 → NP_001157528.1  phospholipase D1 isoform 1

      See identical proteins and their annotated locations for NP_001157528.1

      Status: VALIDATED

      Source sequence(s)
      AC114987, AC132149
      Consensus CDS
      CCDS17275.1
      UniProtKB/Swiss-Prot
      O35911, Q9Z280
      UniProtKB/TrEMBL
      Q6NVF2
      Related
      ENSMUSP00000113810.2, ENSMUST00000120834.8
      Conserved Domains (1) summary
      PLN02866
      Location:82 → 1021
      PLN02866; phospholipase D

    2. NM_001368667.2 → NP_001355596.1  phospholipase D1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC114987, AC132149
      Consensus CDS
      CCDS89617.1
      UniProtKB/Swiss-Prot
      O35911, Q9Z280
      UniProtKB/TrEMBL
      D6RH77
      Related
      ENSMUSP00000118727.3, ENSMUST00000123539.8
      Conserved Domains (1) summary
      PLN02866
      Location:82 → 1059
      PLN02866; phospholipase D

    3. NM_001410530.1 → NP_001397459.1  phospholipase D1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC114987, AC132149
      UniProtKB/TrEMBL
      D6RH77

    4. NM_001410531.1 → NP_001397460.1  phospholipase D1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC114987, AC132149
      UniProtKB/TrEMBL
      Q6NVF2

    5. NM_001410532.1 → NP_001397461.1  phospholipase D1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC114987, AC132149
      UniProtKB/TrEMBL
      Q6NVF2

    6. NM_008875.5 → NP_032901.2  phospholipase D1 isoform 1

      See identical proteins and their annotated locations for NP_032901.2

      Status: VALIDATED

      Source sequence(s)
      AC114987, AC132149
      Consensus CDS
      CCDS17275.1
      UniProtKB/Swiss-Prot
      O35911, Q9Z280
      UniProtKB/TrEMBL
      Q6NVF2
      Related
      ENSMUSP00000064694.5, ENSMUST00000067757.11
      Conserved Domains (1) summary
      PLN02866
      Location:82 → 1021
      PLN02866; phospholipase D

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      27992636..28187388
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017319490.3 → XP_017174979.1  phospholipase D1 isoform X1

      UniProtKB/Swiss-Prot
      O35911, Q9Z280
      UniProtKB/TrEMBL
      D6RH77
      Conserved Domains (1) summary
      PLN02866
      Location:82 → 1059
      PLN02866; phospholipase D

    2. XM_017319489.3 → XP_017174978.1  phospholipase D1 isoform X1

      UniProtKB/Swiss-Prot
      O35911, Q9Z280
      UniProtKB/TrEMBL
      D6RH77
      Conserved Domains (1) summary
      PLN02866
      Location:82 → 1059
      PLN02866; phospholipase D

    3. XM_017319491.3 → XP_017174980.1  phospholipase D1 isoform X1

      UniProtKB/Swiss-Prot
      O35911, Q9Z280
      UniProtKB/TrEMBL
      D6RH77
      Conserved Domains (1) summary
      PLN02866
      Location:82 → 1059
      PLN02866; phospholipase D
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9Z280.1 GenPept UniProtKB/Swiss-Prot:Q9Z280

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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