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    Spp2 secreted phosphoprotein 2 [ Mus musculus (house mouse) ]

    Gene ID: 75396, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Spp2provided by MGI
    Official Full Name
    secreted phosphoprotein 2provided by MGI
    Primary source
    MGI:MGI:1922646
    See related
    Ensembl:ENSMUSG00000026295 AllianceGenome:MGI:1922646
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    pp-24; spp24; 0610038O04Rik
    Summary
    Predicted to be involved in protein-containing complex assembly. Predicted to be located in extracellular region. Predicted to be part of protein-containing complex. Is expressed in embryo endoderm; liver lobe; urinary system; and yolk sac. Orthologous to human SPP2 (secreted phosphoprotein 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in placenta adult (RPKM 478.7), kidney adult (RPKM 348.4) and 4 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    1 D; 1 44.63 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (88334688..88356022)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (88406966..88428300)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene maestro heat-like repeat family member 2A Neighboring gene Holliday junction recognition protein Neighboring gene STARR-positive B cell enhancer mm9_chr1:90185502-90185802 Neighboring gene STARR-positive B cell enhancer mm9_chr1:90186563-90186863 Neighboring gene STARR-positive B cell enhancer mm9_chr1:90195708-90196009 Neighboring gene transient receptor potential cation channel, subfamily M, member 8 Neighboring gene STARR-seq mESC enhancer starr_01631 Neighboring gene STARR-seq mESC enhancer starr_01632 Neighboring gene STARR-seq mESC enhancer starr_01633 Neighboring gene predicted gene 29538 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:90371230-90371404 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:90372096-90372342 Neighboring gene predicted gene 28888 Neighboring gene glutamine repeat protein 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Carboxy terminus of secreted phosphoprotein-24 kDa (spp24) is essential for full inhibition of BMP-2 activity. Brochmann EJ, et al. J Orthop Res, 2010 Sep. PMID 20162696
    2. Characterization of the human secreted phosphoprotein 24 gene (SPP2) and comparison of the protein sequence in nine species. Bennett CS, et al. Matrix Biol, 2004 Feb. PMID 15062857
    3. A systematic screen for genes expressed in definitive endoderm by Serial Analysis of Gene Expression (SAGE). Hou J, et al. BMC Dev Biol, 2007 Aug 2. PMID 17683524, Free PMC Article
    4. Hnf1b haploinsufficiency differentially affects developmental target genes in a new renal cysts and diabetes mouse model. Niborski LL, et al. Dis Model Mech, 2021 May 1. PMID 33737325, Free PMC Article
    5. Inflammation-like changes in the urothelium of Lifr-deficient mice and LIFR-haploinsufficient humans with urinary tract anomalies. Christians A, et al. Hum Mol Genet, 2020 May 8. PMID 32179912

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. proteolytic processing of spp24 affects the interaction of this protein with BMP-2 and this affects the function of the protein
      Title: Carboxy terminus of secreted phosphoprotein-24 kDa (spp24) is essential for full inhibition of BMP-2 activity.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (3) 
    • Endonuclease-mediated (3) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in bone remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein-containing complex assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    secreted phosphoprotein 24
    Names
    secreted phosphoprotein 2, 24kDa

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_029269.3 → NP_083545.1  secreted phosphoprotein 24 precursor

      See identical proteins and their annotated locations for NP_083545.1

      Status: VALIDATED

      Source sequence(s)
      AK002814, BY787973
      Consensus CDS
      CCDS15145.1
      UniProtKB/Swiss-Prot
      Q8K1I3, Q9DCG1
      UniProtKB/TrEMBL
      Q711L0
      Related
      ENSMUSP00000027518.6, ENSMUST00000027518.12
      Conserved Domains (2) summary
      pfam07448
      Location:67 → 203
      Spp-24; Secreted phosphoprotein 24 (Spp-24)
      cl09238
      Location:32 → 100
      CY; Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      88334688..88356022
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006529918.3 → XP_006529981.1  secreted phosphoprotein 24 isoform X1

      Conserved Domains (2) summary
      cl09238
      Location:32 → 99
      CY; Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.
      cl29764
      Location:67 → 108
      Cathelicidins
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8K1I3.2 GenPept UniProtKB/Swiss-Prot:Q8K1I3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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