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    Trip11 thyroid hormone receptor interactor 11 [ Mus musculus (house mouse) ]

    Gene ID: 109181, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Trip11provided by MGI
    Official Full Name
    thyroid hormone receptor interactor 11provided by MGI
    Primary source
    MGI:MGI:1924393
    See related
    Ensembl:ENSMUSG00000021188 AllianceGenome:MGI:1924393
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    TRIP230; GMAP-210; 2610511G22Rik; 3110031G15Rik; 6030460N08Rik
    Summary
    Predicted to enable small GTPase binding activity. Involved in protein localization to ciliary membrane. Acts upstream of or within Golgi organization; animal organ development; and protein glycosylation. Located in acrosomal membrane and cis-Golgi network. Used to study achondrogenesis type IA. Human ortholog(s) of this gene implicated in achondrogenesis type IA. Orthologous to human TRIP11 (thyroid hormone receptor interactor 11). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in bladder adult (RPKM 5.0), cerebellum adult (RPKM 3.6) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Trip11 in Genome Data Viewer
    Location:
    12 E; 12 51.3 cM
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (101800304..101879463, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (101834045..101913171, complement)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 52022 Neighboring gene tandem C2 domains, nuclear Neighboring gene fibulin 5 Neighboring gene STARR-seq mESC enhancer starr_33088 Neighboring gene STARR-seq mESC enhancer starr_33091 Neighboring gene predicted gene, 20036 Neighboring gene ataxin 3 Neighboring gene STARR-positive B cell enhancer ABC_E1452 Neighboring gene STARR-seq mESC enhancer starr_33093 Neighboring gene NADH:ubiquinone oxidoreductase subunit B1 Neighboring gene cleavage and polyadenylation specific factor 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Abnormal fertility, acrosome formation, IFT20 expression and localization in conditional Gmap210 knockout mice. Wang Z, et al. Am J Physiol Cell Physiol, 2020 Jan 1. PMID 31577511, Free PMC Article
    2. The skeletal phenotype of achondrogenesis type 1A is caused exclusively by cartilage defects. Bird IM, et al. Development, 2018 Jan 8. PMID 29180569, Free PMC Article
    3. Golgi disruption and early embryonic lethality in mice lacking USO1. Kim S, et al. PLoS One, 2012. PMID 23185636, Free PMC Article
    4. GMAP210 and IFT88 are present in the spermatid golgi apparatus and participate in the development of the acrosome-acroplaxome complex, head-tail coupling apparatus and tail. Kierszenbaum AL, et al. Dev Dyn, 2011 Mar. PMID 21337470, Free PMC Article
    5. Recruitment of thyroid hormone receptor/retinoblastoma-interacting protein 230 by the aryl hydrocarbon receptor nuclear translocator is required for the transcriptional response to both dioxin and hypoxia. Beischlag TV, et al. J Biol Chem, 2004 Dec 24. PMID 15485806

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Disruption of Trip11 in cranial neural crest cells is associated with increased ER and Golgi stress contributing to skull defects in mice.
      Title: Disruption of Trip11 in cranial neural crest cells is associated with increased ER and Golgi stress contributing to skull defects in mice.
    2. GMAP210 is essential for acrosome biogenesis, normal mitochondrial sheath formation, and male fertility, and it determines expression levels and acrosomal localization of IFT20 and other acrosomal proteins.
      Title: Abnormal fertility, acrosome formation, IFT20 expression and localization in conditional Gmap210 knockout mice.
    3. Data show that IFT88 is present in the Golgi of spermatids, that the microtubule-associated golgin GMAP210 and IFT88 participate in acrosome, HTCA, and tail biogenesis.
      Title: GMAP210 and IFT88 are present in the spermatid golgi apparatus and participate in the development of the acrosome-acroplaxome complex, head-tail coupling apparatus and tail.
    4. mice with lethal skeletal dysplasia had a nonsense mutation in the thyroid hormone receptor interactor 11 gene (Trip11), which encodes the Golgi microtubule-associated protein 210 (GMAP-210)
      Title: Lethal skeletal dysplasia in mice and humans lacking the golgin GMAP-210.
    5. GMAP210 and IFT20 function together at the Golgi in the sorting of proteins destined for the ciliary membrane.
      Title: The Golgin GMAP210/TRIP11 anchors IFT20 to the Golgi complex.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC189992

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables small GTPase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in Golgi organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within Golgi organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in Golgi ribbon formation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within bone development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cartilage development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within chondrocyte differentiation involved in endochondral bone morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within inner ear receptor cell stereocilium organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within protein glycosylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within protein transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within ventricular septum development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in vesicle tethering to Golgi ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in acrosomal membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cis-Golgi network IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum-Golgi intermediate compartment ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in inner acrosomal membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in outer acrosomal membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    thyroid receptor-interacting protein 11

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_028446.1 → NP_082722.1  thyroid receptor-interacting protein 11

      Status: VALIDATED

      Source sequence(s)
      AC121965
      Consensus CDS
      CCDS49143.1
      UniProtKB/TrEMBL
      B2RY51, E9Q512
      Related
      ENSMUSP00000021605.8, ENSMUST00000021605.14
      Conserved Domains (2) summary
      COG1196
      Location:946 → 1768
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:226 → 1065
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      101800304..101879463 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006515382.4 → XP_006515445.1  thyroid receptor-interacting protein 11 isoform X1

      UniProtKB/TrEMBL
      B2RY51
      Conserved Domains (2) summary
      COG1196
      Location:945 → 1767
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:225 → 1064
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    2. XM_011243986.3 → XP_011242288.1  thyroid receptor-interacting protein 11 isoform X2

      UniProtKB/TrEMBL
      B2RY51
      Conserved Domains (2) summary
      COG1196
      Location:882 → 1704
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:162 → 1001
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    3. XM_036157159.1 → XP_036013052.1  thyroid receptor-interacting protein 11 isoform X3

      UniProtKB/TrEMBL
      H3BJG4
      Conserved Domains (2) summary
      COG1196
      Location:10 → 764
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam10375
      Location:1370 → 1415
      GRAB; GRIP-related Arf-binding domain

    RNA

    1. XR_004937402.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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