Gabrr1 gamma-aminobutyric acid type A receptor subunit rho 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Gabrr1provided by MGI
Official Full Name: gamma-aminobutyric acid type A receptor subunit rho 1provided by MGI
Primary source: MGI:MGI:95625
See related: Ensembl:ENSMUSG00000028280 AllianceGenome:MGI:95625
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: GABA-C
Summary: Enables ligand-gated ion channel activity involved in regulation of presynaptic membrane potential and transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential. Predicted to be involved in several processes, including chemical synaptic transmission; chloride transmembrane transport; and regulation of membrane potential. Predicted to act upstream of or within chloride transport. Located in glutamatergic synapse. Is active in GABA-ergic synapse. Is expressed in brain; cerebral cortex; and retina. Orthologous to human GABRR1 (gamma-aminobutyric acid type A receptor subunit rho1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in genital fat pad adult (RPKM 2.0) and CNS E18 (RPKM 0.1) See more
Orthologs: human all
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Genomic context

Location:: 4 A5; 4 14.68 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (33132556..33163606)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (33132556..33163588)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

GABRR1 is a rho subunit receptor of GABA, the major inhibitory neurotransmitter in the mammalian brain. The GABA receptor GABRR1 is expressed on and functional in hematopoietic stem cells and megakaryocyte progenitors.
Title: The GABA receptor GABRR1 is expressed on and functional in hematopoietic stem cells and megakaryocyte progenitors.
GABACR antagonists differed in their effects on nSTR and PhNR; antagonists with GABAB agonist properties enhanced light-driven responses whereas 2-AEMP did not.
Title: In vivo electroretinographic studies of the role of GABAC receptors in retinal signal processing.
GABArho has a role in the bicuculline-insensitive component of GFAP+ cells of cerebellum
Title: GABAρ subunits confer a bicuculline-insensitive component to GFAP+ cells of cerebellum.
Ethanol action on GABAA receptors containing rho1/rho2 subunits may be important for specific effects of ethanol in vivo.
Title: GABAA receptors containing ρ1 subunits contribute to in vivo effects of ethanol in mice.
Identification of a fragment flanking the GABArho1 gene promoter paves the way for studies of molecular elements that control GABArho1 transcription and regulate its expression during retinal development.
Title: Identification of the minimal promoter for specific expression of the GABAρ1 receptor in retinal bipolar cells.
GABA(C) receptors play a general role for the control of neuronal excitability in subcortical visual pathways.
Title: Contribution of GABA(C) receptors to inhibition in the rodent accessory optic system.
activation of peripheral GABA-Rs may provide a new modality to modulate T cell, B cell, and APC activity and help ameliorate RA and other inflammatory diseases.
Title: Oral GABA treatment downregulates inflammatory responses in a mouse model of rheumatoid arthritis.
In GABA(C) rho1 Null stratum griseum superficiale (SGS) cells, inhibitory postsynaptic currents were shorter in duration and their excitatory postsynaptic currents were longer, indicating that a slow GABA(C)R-mediated inhibitory component was reduced.
Title: GABAC receptor-mediated inhibition is altered but not eliminated in the superior colliculus of GABAC rho1 knockout mice.
GABA(C) receptors and protein phosphatase 1 (PP1) simultaneously bind to different domains of PNUTS, the targeting subunit of PP1.
Title: PNUTS forms a trimeric protein complex with GABA(C) receptors and protein phosphatase 1.
the GABA receptor/channel rho 1 subunit plays an important role in modulating spinal cord pain transmission functions in vivo
Title: Function of gamma-aminobutyric acid receptor/channel rho 1 subunits in spinal cord.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation
Endonuclease-mediated (3) 1 citation

General gene information

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Markers

AF024620 (e-PCR)
- UniSTS:178976

Gabrr1 (e-PCR), detects polymorphism
- UniSTS:234040

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables GABA receptor activity	ISO Inferred from Sequence Orthology more info
enables GABA-A receptor activity	IBA Inferred from Biological aspect of Ancestor more info
contributes_to chloride channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables extracellular ligand-gated monoatomic ion channel activity	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	EXP Inferred from Experiment more info	PubMed
enables ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	IDA Inferred from Direct Assay more info	PubMed
enables monoatomic ion channel activity	IEA Inferred from Electronic Annotation more info
enables neurotransmitter receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein domain specific binding	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables transmembrane signaling receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in chemical synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info
involved_in chloride transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within chloride transport	IEA Inferred from Electronic Annotation more info
involved_in modulation of chemical synaptic transmission	EXP Inferred from Experiment more info	PubMed
involved_in modulation of chemical synaptic transmission	IDA Inferred from Direct Assay more info	PubMed
involved_in modulation of chemical synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within monoatomic ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in monoatomic ion transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of membrane potential	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of GABA-A receptor complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in GABA-ergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in GABA-ergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
part_of chloride channel complex	IEA Inferred from Electronic Annotation more info
is_active_in glutamatergic synapse	EXP Inferred from Experiment more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in postsynaptic membrane	IEA Inferred from Electronic Annotation more info
is_active_in presynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in synapse	IBA Inferred from Biological aspect of Ancestor more info
part_of transmembrane transporter complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: gamma-aminobutyric acid receptor subunit rho-1

Names: GABA(A) receptor subunit rho-1; GABA(C) receptor; gamma-aminobutyric acid (GABA) C receptor, subunit rho 1; gamma-aminobutyric acid (GABA-A) receptor, subunit rho 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_008075.2 → NP_032101.3 gamma-aminobutyric acid receptor subunit rho-1 precursor

See identical proteins and their annotated locations for NP_032101.3

Status: VALIDATED

Source sequence(s)

AF024620, AL670464, BI736525

Consensus CDS

CCDS18021.2

UniProtKB/Swiss-Prot

A3KG51, P56475

Related

ENSMUSP00000029947.7, ENSMUST00000029947.6

Conserved Domains (2) summary

cd19005
Location:97 → 282

LGIC_ECD_GABAAR_rho; extracellular domain of gamma-aminobutyric acid receptor subunit rho

cl42365
Location:76 → 479

LIC; Cation transporter family protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000070.7 Reference GRCm39 C57BL/6J

Range

33132556..33163606

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006537613.5 → XP_006537676.1 gamma-aminobutyric acid receptor subunit rho-1 isoform X2

Conserved Domains (2) summary

TIGR00860
Location:58 → 461

LIC; Cation transporter family protein

cd19005
Location:79 → 264

LGIC_ECD_GABAAR_rho; extracellular domain of gamma-aminobutyric acid receptor subunit rho
XM_006537612.2 → XP_006537675.1 gamma-aminobutyric acid receptor subunit rho-1 isoform X1

Conserved Domains (2) summary

TIGR00860
Location:70 → 473

LIC; Cation transporter family protein

cd19005
Location:91 → 276

LGIC_ECD_GABAAR_rho; extracellular domain of gamma-aminobutyric acid receptor subunit rho