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    Ces1f carboxylesterase 1F [ Mus musculus (house mouse) ]

    Gene ID: 234564, updated on 23-Jun-2021

    Summary

    Official Symbol
    Ces1fprovided by MGI
    Official Full Name
    carboxylesterase 1Fprovided by MGI
    Primary source
    MGI:MGI:2142687
    See related
    Ensembl:ENSMUSG00000031725
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CesM; TGH-2; CesML1; AU018778
    Expression
    Biased expression in liver adult (RPKM 84.6), kidney adult (RPKM 21.8) and 7 other tissues See more
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    Genomic context

    See Ces1f in Genome Data Viewer
    Location:
    8; 8 C5
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (93982864..94006394, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (93256236..93279766, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (95780135..95803635, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene carboxylesterase 1D Neighboring gene carboxylesterase 1E Neighboring gene carboxylesterase 1G Neighboring gene carboxylesterase 1H

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    General gene information

    Markers

    Clone Names

    • MGC18894

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables carboxylic ester hydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables carboxylic ester hydrolase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables methyl indole-3-acetate esterase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables sterol esterase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in cellular response to cholesterol ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to low-density lipoprotein particle stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cholesterol biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cholesterol homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cholesterol metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in epithelial cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in lipid catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in medium-chain fatty acid metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cholesterol storage ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cholesterol efflux ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cholesterol metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of bile acid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of bile acid secretion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in reverse cholesterol transport ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within short-chain fatty acid catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in lipid droplet IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in lipid droplet IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in lipid droplet ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    carboxylesterase 1F
    Names
    carboxylic ester hydrolase
    liver carboxylesterase B-1
    triacylglycerol hydrolase 2
    NP_659179.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_144930.2NP_659179.1  carboxylesterase 1F precursor

      See identical proteins and their annotated locations for NP_659179.1

      Status: VALIDATED

      Source sequence(s)
      AI174063, AI786051, AK136491, BB583655, EH107325
      Consensus CDS
      CCDS22530.1
      UniProtKB/Swiss-Prot
      Q91WU0
      Related
      ENSMUSP00000034178.9, ENSMUST00000034178.9
      Conserved Domains (2) summary
      COG0657
      Location:121225
      Aes; Acetyl esterase/lipase [Lipid transport and metabolism]
      pfam00135
      Location:24545
      COesterase; Carboxylesterase family

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      93982864..94006394 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_387740.1 RNA Sequence

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