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    Sec61g SEC61 translocon subunit gamma [ Mus musculus (house mouse) ]

    Gene ID: 20335, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Sec61gprovided by MGI
    Official Full Name
    SEC61 translocon subunit gammaprovided by MGI
    Primary source
    MGI:MGI:1202066
    See related
    Ensembl:ENSMUSG00000078974 AllianceGenome:MGI:1202066
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable protein transmembrane transporter activity. Predicted to be involved in posttranslational protein targeting to membrane, translocation. Predicted to be located in membrane. Predicted to be part of Ssh1 translocon complex. Is expressed in lung epithelium; ovary; and seminiferous cord. Orthologous to human SEC61G (SEC61 translocon subunit gamma). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in liver E14 (RPKM 73.5), placenta adult (RPKM 63.1) and 24 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    11 A2; 11 9.41 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (16451638..16458484, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (16501638..16508484, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene V-set and transmembrane domain containing 2A Neighboring gene STARR-seq mESC enhancer starr_28683 Neighboring gene STARR-seq mESC enhancer starr_28684 Neighboring gene STARR-seq mESC enhancer starr_28685 Neighboring gene predicted gene 12012 Neighboring gene STARR-seq mESC enhancer starr_28687 Neighboring gene STARR-positive B cell enhancer ABC_E11470 Neighboring gene STARR-seq mESC enhancer starr_28688 Neighboring gene thymoma viral proto-oncogene 2, pseudogene Neighboring gene VISTA enhancer mm1103 Neighboring gene ubiquitin-like domain containing CTD phosphatase 1 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Tumor necrosis factor induces genes involved in inflammation, cellular and tissue repair, and metabolism in murine fibroblasts. Gordon HM, et al. J Immunol, 1992 Jun 15. PMID 1602141
    2. Ablation of cholesterol biosynthesis in neural stem cells increases their VEGF expression and angiogenesis but causes neuron apoptosis. Saito K, et al. Proc Natl Acad Sci U S A, 2009 May 19. PMID 19416849, Free PMC Article
    3. Differential gene expression in the distal tip endoderm of the embryonic mouse lung. Liu Y, et al. Gene Expr Patterns, 2002 Dec. PMID 12617806
    4. Different effects of Sec61α, Sec62 and Sec63 depletion on transport of polypeptides into the endoplasmic reticulum of mammalian cells. Lang S, et al. J Cell Sci, 2012 Apr 15. PMID 22375059, Free PMC Article
    5. Large-scale screen for genes involved in gonad development. Wertz K, et al. Mech Dev, 2000 Nov. PMID 11044607

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SEC61G assists EGFR-amplified glioblastoma to evade immune elimination.
      Title: SEC61G assists EGFR-amplified glioblastoma to evade immune elimination.
    2. Sec61gamma is a vital protein in the endoplasmic reticulum membrane promoting tumor metastasis and invasion in lung adenocarcinoma.
      Title: Sec61γ is a vital protein in the endoplasmic reticulum membrane promoting tumor metastasis and invasion in lung adenocarcinoma.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ribosome binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in post-translational protein targeting to membrane, translocation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein targeting IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of Ssh1 translocon complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    protein transport protein Sec61 subunit gamma
    Names
    SEC61, gamma subunit

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001109971.1 → NP_001103441.1  protein transport protein Sec61 subunit gamma isoform 2

      See identical proteins and their annotated locations for NP_001103441.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) includes an alternate segment in exon 1, compared to variant 1. This causes translation initiation at a downstream AUG and an isoform (2) with a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AK012393, AK012644, BY468217, CO808059
      Consensus CDS
      CCDS48755.1
      UniProtKB/Swiss-Prot
      P60060
      UniProtKB/TrEMBL
      Q5SWJ8
      Related
      ENSMUSP00000137362.2, ENSMUST00000178855.8
      Conserved Domains (1) summary
      cl00481
      Location:12 → 68
      SecE; SecE/Sec61-gamma subunits of protein translocation complex

    2. NM_001109972.1 → NP_001103442.1  protein transport protein Sec61 subunit gamma isoform 2

      See identical proteins and their annotated locations for NP_001103442.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) includes an alternate segment in exon 1, compared to variant 1. This causes translation initiation at a downstream AUG and an isoform (2) with a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AK012644, AV456975, CO808059
      Consensus CDS
      CCDS48755.1
      UniProtKB/Swiss-Prot
      P60060
      UniProtKB/TrEMBL
      Q5SWJ8
      Related
      ENSMUSP00000105270.2, ENSMUST00000109642.8
      Conserved Domains (1) summary
      cl00481
      Location:12 → 68
      SecE; SecE/Sec61-gamma subunits of protein translocation complex

    3. NM_011343.3 → NP_035473.2  protein transport protein Sec61 subunit gamma isoform 1

      See identical proteins and their annotated locations for NP_035473.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AK012644, CO808059
      Consensus CDS
      CCDS48756.1
      UniProtKB/TrEMBL
      G3UWH0
      Related
      ENSMUSP00000132348.2, ENSMUST00000166950.8
      Conserved Domains (1) summary
      cl00481
      Location:44 → 100
      SecE; SecE/Sec61-gamma subunits of protein translocation complex

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      16451638..16458484 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P60060.1 GenPept UniProtKB/Swiss-Prot:P60060

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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