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    Zfp282 zinc finger protein 282 [ Mus musculus (house mouse) ]

    Gene ID: 101095, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Zfp282provided by MGI
    Official Full Name
    zinc finger protein 282provided by MGI
    Primary source
    MGI:MGI:2141413
    See related
    Ensembl:ENSMUSG00000025821 AllianceGenome:MGI:2141413
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    HUB1; E430019K09Rik
    Summary
    Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Is expressed in 1st branchial arch maxillary component; early conceptus; genitourinary system; and limb. Orthologous to human ZNF282 (zinc finger protein 282). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in whole brain E14.5 (RPKM 8.4), CNS E18 (RPKM 7.7) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    6 B2.3; 6 22.94 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (47853433..47885419)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (47877209..47908485)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein L35A, pseudogene 7 Neighboring gene STARR-seq mESC enhancer starr_15785 Neighboring gene zinc finger protein 786 Neighboring gene zinc finger protein 398 Neighboring gene predicted gene, 52899 Neighboring gene Zinc finger protein 212 Neighboring gene STARR-positive B cell enhancer ABC_E8099 Neighboring gene zinc finger protein 783 Neighboring gene zinc finger protein 956

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Guo G, et al. Dev Cell, 2010 Apr 20. PMID 20412781
    2. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article
    3. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    4. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518
    5. GUDMAP: the genitourinary developmental molecular anatomy project. McMahon AP, et al. J Am Soc Nephrol, 2008 Apr. PMID 18287559

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC36603

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 282

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_146175.3 → NP_666287.3  zinc finger protein 282

      Status: VALIDATED

      Source sequence(s)
      AC166248, AK030516, AK030919, AK148038, BX524317, BY129988
      Consensus CDS
      CCDS20100.1
      UniProtKB/TrEMBL
      E9PVC2, Q8R3D4
      Related
      ENSMUSP00000053643.7, ENSMUST00000061890.8
      Conserved Domains (6) summary
      smart00349
      Location:198 → 260
      KRAB; krueppel associated box
      COG5048
      Location:568 → 621
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:544 → 564
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:570 → 592
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:198 → 237
      KRAB; KRAB box
      pfam13465
      Location:612 → 637
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      47853433..47885419
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011241099.4 → XP_011239401.1  zinc finger protein 282 isoform X1

      UniProtKB/TrEMBL
      Q8R3D4
      Conserved Domains (5) summary
      smart00349
      Location:198 → 260
      KRAB; krueppel associated box
      sd00017
      Location:516 → 536
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:514 → 536
      zf-C2H2; Zinc finger, C2H2 type
      pfam12417
      Location:112 → 168
      DUF3669; Zinc finger protein
      pfam13465
      Location:528 → 553
      zf-H2C2_2; Zinc-finger double domain
    Nucleotide Protein Strain
    Heading Accession and Version

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