Cacna1b calcium channel, voltage-dependent, N type, alpha 1B subunit [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cacna1bprovided by MGI
Official Full Name: calcium channel, voltage-dependent, N type, alpha 1B subunitprovided by MGI
Primary source: MGI:MGI:88296
See related: Ensembl:ENSMUSG00000004113 AllianceGenome:MGI:88296
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: BIII; Cav2.2; Cchn1a; alpha(1B)
Summary: Enables high voltage-gated calcium channel activity. Acts upstream of or within several processes, including calcium ion transmembrane transport; neurotransmitter secretion; and response to pain. Located in dendrite; membrane; and neuronal cell body. Part of voltage-gated calcium channel complex. Is expressed in several structures, including adrenal gland; alimentary system; brain; genitourinary system; and retina. Human ortholog(s) of this gene implicated in Lambert-Eaton myasthenic syndrome and dystonia 23. Orthologous to human CACNA1B (calcium voltage-gated channel subunit alpha1 B). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in CNS E18 (RPKM 11.3), whole brain E14.5 (RPKM 9.4) and 8 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 A3; 2 16.58 cM

Exon count:: 51

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (24493872..24653210, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (24603860..24763200, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Cav2.2 Channels Sustain Vesicle Recruitment at a Mature Glutamatergic Synapse.
Title: Ca(v)2.2 Channels Sustain Vesicle Recruitment at a Mature Glutamatergic Synapse.
N-type calcium channel v2.2 is a target of TCF21 in adrenocortical carcinomas.
Title: N-type calcium channel v2.2 is a target of TCF21 in adrenocortical carcinomas.
Constitutive activity of dopamine receptor type 1 (D1R) increases CaV2.2 currents in PFC neurons.
Title: Constitutive activity of dopamine receptor type 1 (D1R) increases CaV2.2 currents in PFC neurons.
Knockdown of microglial Cav2.2 N-type voltage-dependent Ca(2+) channel ameliorates behavioral deficits in a mouse model of Parkinson's disease.
Title: Knockdown of microglial Cav2.2 N-type voltage-dependent Ca(2+) channel ameliorates behavioral deficits in a mouse model of Parkinson's disease.
Involvement of N-type Ca(2+) channel in microglial activation and its implications to aging-induced exaggerated cytokine response.
Title: Involvement of N-type Ca(2+) channel in microglial activation and its implications to aging-induced exaggerated cytokine response.
alternative splicing of Cacna1b e37a influences excitatory transmitter release and couples to complex behaviors.
Title: Cacna1b alternative splicing impacts excitatory neurotransmission and is linked to behavioral responses to aversive stimuli.
Co-immunoprecipitations from brain tissue is consistent with the formation of a protein complex between RB-3alpha and RB-3beta and both Cav2.2 and the related Cav2.1 calcium channel.
Title: Interactions of Rabconnectin-3 with Cav2 calcium channels.
The studies and identified +e18a-Cacna1b mRNA in deep cerebellar cells and spinal cord motor neurons and +e18a-Cacna1b is enriched in cholecystokinin-expressing interneurons.
Title: Tissue- and cell-specific expression of a splice variant in the II-III cytoplasmic loop of Cacna1b.
Munc13-3 regulates the density of Cav2.1 and Cav2.2 channels, alters the localization of Cav2.1, and is required for the development of tight, nanodomain coupling at parallel-fiber active zones.
Title: Munc13-3 Is Required for the Developmental Localization of Ca(2+) Channels to Active Zones and the Nanopositioning of Ca(v)2.1 Near Release Sensors.
It is essential for presynaptic neurotransmitter release.
Title: N-type Ca(2+) channels are affected by full-length mutant huntingtin expression in a mouse model of Huntington's disease.

Submit: New GeneRIF Correction See all GeneRIFs (39)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (12) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AW060892 (e-PCR)
- UniSTS:178582

AW050276 (e-PCR)
- UniSTS:178583

AW822256 (e-PCR)
- UniSTS:207299

D9S218E (e-PCR)
- UniSTS:473063

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables calcium channel activity	IEA Inferred from Electronic Annotation more info
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables high voltage-gated calcium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables high voltage-gated calcium channel activity	IDA Inferred from Direct Assay more info	PubMed
enables high voltage-gated calcium channel activity	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables monoatomic ion channel activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein phosphatase 2A binding	ISO Inferred from Sequence Orthology more info
enables voltage-gated calcium channel activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables voltage-gated calcium channel activity	ISO Inferred from Sequence Orthology more info
enables voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in calcium ion import	ISO Inferred from Sequence Orthology more info
involved_in calcium ion import across plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within calcium ion transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within calcium ion transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in calcium ion transport	ISO Inferred from Sequence Orthology more info
involved_in chemical synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within establishment of localization in cell	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within locomotory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in modulation of chemical synaptic transmission	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within monoatomic ion transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in monoatomic ion transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within neurotransmitter secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of neurotransmitter secretion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of blood pressure	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of calcium ion transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of calcium-dependent activation of synaptic vesicle fusion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of heart contraction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to amyloid-beta	ISO Inferred from Sequence Orthology more info
involved_in response to organic cyclic compound	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to pain	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to testosterone	ISO Inferred from Sequence Orthology more info
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in Schaffer collateral - CA1 synapse	ISO Inferred from Sequence Orthology more info
located_in axon terminus	ISO Inferred from Sequence Orthology more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in dendritic shaft	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
part_of monoatomic ion channel complex	IEA Inferred from Electronic Annotation more info
is_active_in neuronal cell body	IBA Inferred from Biological aspect of Ancestor more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
is_active_in presynaptic active zone	IDA Inferred from Direct Assay more info	PubMed
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
part_of voltage-gated calcium channel complex	IBA Inferred from Biological aspect of Ancestor more info
part_of voltage-gated calcium channel complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: voltage-dependent N-type calcium channel subunit alpha-1B

Names: brain calcium channel III; calcium channel, L type, alpha-1 polypeptide; calcium channel, voltage-dependent, L type, alpha 1B subunit; calcium channel, voltage-dependent, N type, alpha 1B subunit, BIII; voltage-gated calcium channel subunit alpha Cav2.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001042528.3 → NP_001035993.1 voltage-dependent N-type calcium channel subunit alpha-1B isoform 1

See identical proteins and their annotated locations for NP_001035993.1

Status: VALIDATED

Source sequence(s)

AL732525, AL732546, BX294112

Consensus CDS

CCDS38065.1

UniProtKB/Swiss-Prot

O55017, Q60609

UniProtKB/TrEMBL

A2AIR7

Related

ENSMUSP00000037416.6, ENSMUST00000041342.12

Conserved Domains (3) summary

pfam00520
Location:1481 → 1710

Ion_trans; Ion transport protein

pfam08763
Location:1784 → 1858

Ca_chan_IQ; Voltage gated calcium channel IQ domain

pfam16905
Location:1718 → 1782

GPHH; Voltage-dependent L-type calcium channel, IQ-associated
NM_007579.4 → NP_031605.2 voltage-dependent N-type calcium channel subunit alpha-1B isoform 2

Status: VALIDATED

Source sequence(s)

AL732525, AL732546, BX294112

Consensus CDS

CCDS15739.1

UniProtKB/TrEMBL

A2AIR7, A2AIS0

Related

ENSMUSP00000063236.8, ENSMUST00000070864.14

Conserved Domains (3) summary

pfam00520
Location:1476 → 1707

Ion_trans; Ion transport protein

pfam08763
Location:1781 → 1819

Ca_chan_IQ; Voltage gated calcium channel IQ domain

pfam16905
Location:1715 → 1779

GPHH; Voltage-dependent L-type calcium channel, IQ-associated

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

24493872..24653210 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006497635.4 → XP_006497698.1 voltage-dependent N-type calcium channel subunit alpha-1B isoform X13

UniProtKB/TrEMBL

A2AIR7

Conserved Domains (4) summary

PHA03307
Location:1884 → 2251

PHA03307; transcriptional regulator ICP4; Provisional

pfam01271
Location:936 → 1041

Granin; Granin (chromogranin or secretogranin)

pfam00520
Location:94 → 367

Ion_trans; Ion transport protein

pfam08763
Location:1733 → 1807

Ca_chan_IQ; Voltage gated calcium channel IQ domain
XM_006497634.3 → XP_006497697.1 voltage-dependent N-type calcium channel subunit alpha-1B isoform X12

UniProtKB/TrEMBL

A2AIR7

Conserved Domains (5) summary

PHA03307
Location:1932 → 2299

PHA03307; transcriptional regulator ICP4; Provisional

pfam01271
Location:913 → 1018

Granin; Granin (chromogranin or secretogranin)

pfam00520
Location:1458 → 1707

Ion_trans; Ion transport protein

pfam08763
Location:1781 → 1855

Ca_chan_IQ; Voltage gated calcium channel IQ domain

pfam16905
Location:1716 → 1769

GPHH; Voltage-dependent L-type calcium channel, IQ-associated
XM_006497632.3 → XP_006497695.1 voltage-dependent N-type calcium channel subunit alpha-1B isoform X10

UniProtKB/TrEMBL

A2AIR7, A2AIR9

Related

ENSMUSP00000100003.3, ENSMUST00000102939.9

Conserved Domains (5) summary

PHA03307
Location:1933 → 2300

PHA03307; transcriptional regulator ICP4; Provisional

pfam01271
Location:914 → 1019

Granin; Granin (chromogranin or secretogranin)

pfam00520
Location:1459 → 1708

Ion_trans; Ion transport protein

pfam08763
Location:1782 → 1856

Ca_chan_IQ; Voltage gated calcium channel IQ domain

pfam16905
Location:1717 → 1770

GPHH; Voltage-dependent L-type calcium channel, IQ-associated
XM_017315156.1 → XP_017170645.1 voltage-dependent N-type calcium channel subunit alpha-1B isoform X18

UniProtKB/TrEMBL

A2AIR7

Conserved Domains (5) summary

PHA03307
Location:1952 → 2319

PHA03307; transcriptional regulator ICP4; Provisional

pfam01271
Location:935 → 1040

Granin; Granin (chromogranin or secretogranin)

pfam00520
Location:1480 → 1727

Ion_trans; Ion transport protein

pfam08763
Location:1801 → 1875

Ca_chan_IQ; Voltage gated calcium channel IQ domain

pfam16905
Location:1736 → 1789

GPHH; Voltage-dependent L-type calcium channel, IQ-associated
XM_017315140.1 → XP_017170629.1 voltage-dependent N-type calcium channel subunit alpha-1B isoform X3

UniProtKB/TrEMBL

A2AIR7

Conserved Domains (5) summary

PHA03307
Location:1958 → 2325

PHA03307; transcriptional regulator ICP4; Provisional

pfam01271
Location:935 → 1040

Granin; Granin (chromogranin or secretogranin)

pfam00520
Location:1484 → 1733

Ion_trans; Ion transport protein

pfam08763
Location:1807 → 1881

Ca_chan_IQ; Voltage gated calcium channel IQ domain

pfam16905
Location:1742 → 1795

GPHH; Voltage-dependent L-type calcium channel, IQ-associated
XM_017315146.1 → XP_017170635.1 voltage-dependent N-type calcium channel subunit alpha-1B isoform X9

UniProtKB/TrEMBL

A2AIR7

Conserved Domains (5) summary

PHA03307
Location:1937 → 2304

PHA03307; transcriptional regulator ICP4; Provisional

pfam01271
Location:914 → 1019

Granin; Granin (chromogranin or secretogranin)

pfam00520
Location:1463 → 1712

Ion_trans; Ion transport protein

pfam08763
Location:1786 → 1860

Ca_chan_IQ; Voltage gated calcium channel IQ domain

pfam16905
Location:1721 → 1774

GPHH; Voltage-dependent L-type calcium channel, IQ-associated
XM_006497633.3 → XP_006497696.1 voltage-dependent N-type calcium channel subunit alpha-1B isoform X11

UniProtKB/TrEMBL

A2AIR7

Conserved Domains (5) summary

PHA03307
Location:1932 → 2299

PHA03307; transcriptional regulator ICP4; Provisional

pfam01271
Location:915 → 1020

Granin; Granin (chromogranin or secretogranin)

pfam00520
Location:1460 → 1707

Ion_trans; Ion transport protein

pfam08763
Location:1781 → 1855

Ca_chan_IQ; Voltage gated calcium channel IQ domain

pfam16905
Location:1716 → 1769

GPHH; Voltage-dependent L-type calcium channel, IQ-associated
XM_006497631.3 → XP_006497694.1 voltage-dependent N-type calcium channel subunit alpha-1B isoform X8

UniProtKB/TrEMBL

A2AIR7

Conserved Domains (5) summary

PHA03307
Location:1938 → 2305

PHA03307; transcriptional regulator ICP4; Provisional

pfam01271
Location:915 → 1020

Granin; Granin (chromogranin or secretogranin)

pfam00520
Location:1464 → 1713

Ion_trans; Ion transport protein

pfam08763
Location:1787 → 1861

Ca_chan_IQ; Voltage gated calcium channel IQ domain

pfam16905
Location:1722 → 1775

GPHH; Voltage-dependent L-type calcium channel, IQ-associated
XM_006497629.3 → XP_006497692.1 voltage-dependent N-type calcium channel subunit alpha-1B isoform X6

UniProtKB/TrEMBL

A2AIR7

Conserved Domains (5) summary

PHA03307
Location:1954 → 2321

PHA03307; transcriptional regulator ICP4; Provisional

pfam01271
Location:935 → 1040

Granin; Granin (chromogranin or secretogranin)

pfam00520
Location:1480 → 1729

Ion_trans; Ion transport protein

pfam08763
Location:1803 → 1877

Ca_chan_IQ; Voltage gated calcium channel IQ domain

pfam16905
Location:1738 → 1791

GPHH; Voltage-dependent L-type calcium channel, IQ-associated
XM_006497627.3 → XP_006497690.1 voltage-dependent N-type calcium channel subunit alpha-1B isoform X2

UniProtKB/TrEMBL

A2AIR7

Conserved Domains (5) summary

PHA03307
Location:1958 → 2325

PHA03307; transcriptional regulator ICP4; Provisional

pfam01271
Location:935 → 1040

Granin; Granin (chromogranin or secretogranin)

pfam00520
Location:1484 → 1733

Ion_trans; Ion transport protein

pfam08763
Location:1807 → 1881

Ca_chan_IQ; Voltage gated calcium channel IQ domain

pfam16905
Location:1742 → 1795

GPHH; Voltage-dependent L-type calcium channel, IQ-associated
XM_006497630.3 → XP_006497693.1 voltage-dependent N-type calcium channel subunit alpha-1B isoform X7

UniProtKB/TrEMBL

A2AIR7

Conserved Domains (5) summary

PHA03307
Location:1953 → 2320

PHA03307; transcriptional regulator ICP4; Provisional

pfam01271
Location:936 → 1041

Granin; Granin (chromogranin or secretogranin)

pfam00520
Location:1481 → 1728

Ion_trans; Ion transport protein

pfam08763
Location:1802 → 1876

Ca_chan_IQ; Voltage gated calcium channel IQ domain

pfam16905
Location:1737 → 1790

GPHH; Voltage-dependent L-type calcium channel, IQ-associated
XM_006497628.3 → XP_006497691.1 voltage-dependent N-type calcium channel subunit alpha-1B isoform X5

UniProtKB/TrEMBL

A2AIR7

Conserved Domains (5) summary

PHA03307
Location:1955 → 2322

PHA03307; transcriptional regulator ICP4; Provisional

pfam01271
Location:936 → 1041

Granin; Granin (chromogranin or secretogranin)

pfam00520
Location:1481 → 1730

Ion_trans; Ion transport protein

pfam08763
Location:1804 → 1878

Ca_chan_IQ; Voltage gated calcium channel IQ domain

pfam16905
Location:1739 → 1792

GPHH; Voltage-dependent L-type calcium channel, IQ-associated
XM_017315141.1 → XP_017170630.1 voltage-dependent N-type calcium channel subunit alpha-1B isoform X4

UniProtKB/TrEMBL

A2AIR7

Conserved Domains (5) summary

PHA03307
Location:1957 → 2324

PHA03307; transcriptional regulator ICP4; Provisional

pfam01271
Location:936 → 1041

Granin; Granin (chromogranin or secretogranin)

pfam00520
Location:1485 → 1732

Ion_trans; Ion transport protein

pfam08763
Location:1806 → 1880

Ca_chan_IQ; Voltage gated calcium channel IQ domain

pfam16905
Location:1741 → 1794

GPHH; Voltage-dependent L-type calcium channel, IQ-associated
XM_006497626.3 → XP_006497689.1 voltage-dependent N-type calcium channel subunit alpha-1B isoform X1

UniProtKB/TrEMBL

A2AIR7

Conserved Domains (5) summary

PHA03307
Location:1959 → 2326

PHA03307; transcriptional regulator ICP4; Provisional

pfam01271
Location:936 → 1041

Granin; Granin (chromogranin or secretogranin)

pfam00520
Location:1485 → 1734

Ion_trans; Ion transport protein

pfam08763
Location:1808 → 1882

Ca_chan_IQ; Voltage gated calcium channel IQ domain

pfam16905
Location:1743 → 1796

GPHH; Voltage-dependent L-type calcium channel, IQ-associated
XM_011239014.2 → XP_011237316.1 voltage-dependent N-type calcium channel subunit alpha-1B isoform X17

UniProtKB/TrEMBL

Q3UYN6

Conserved Domains (4) summary

PHA03307
Location:850 → 1217

PHA03307; transcriptional regulator ICP4; Provisional

pfam00520
Location:376 → 625

Ion_trans; Ion transport protein

pfam08763
Location:699 → 773

Ca_chan_IQ; Voltage gated calcium channel IQ domain

pfam16905
Location:634 → 687

GPHH; Voltage-dependent L-type calcium channel, IQ-associated
XM_006497637.5 → XP_006497700.1 voltage-dependent N-type calcium channel subunit alpha-1B isoform X14

Conserved Domains (3) summary

pfam01271
Location:936 → 1041

Granin; Granin (chromogranin or secretogranin)

pfam00520
Location:1485 → 1734

Ion_trans; Ion transport protein

pfam16905
Location:1743 → 1756

GPHH; Voltage-dependent L-type calcium channel, IQ-associated
XM_017315155.2 → XP_017170644.1 voltage-dependent N-type calcium channel subunit alpha-1B isoform X16

Conserved Domains (3) summary

pfam01271
Location:936 → 1041

Granin; Granin (chromogranin or secretogranin)

pfam00520
Location:1481 → 1728

Ion_trans; Ion transport protein

pfam16905
Location:1737 → 1782

GPHH; Voltage-dependent L-type calcium channel, IQ-associated
XM_006497638.4 → XP_006497701.1 voltage-dependent N-type calcium channel subunit alpha-1B isoform X15

Conserved Domains (3) summary

pfam01271
Location:936 → 1041

Granin; Granin (chromogranin or secretogranin)

pfam00520
Location:1485 → 1734

Ion_trans; Ion transport protein

pfam16905
Location:1743 → 1788

GPHH; Voltage-dependent L-type calcium channel, IQ-associated