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    Sart3 squamous cell carcinoma antigen recognized by T cells 3 [ Mus musculus (house mouse) ]

    Gene ID: 53890, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Sart3provided by MGI
    Official Full Name
    squamous cell carcinoma antigen recognized by T cells 3provided by MGI
    Primary source
    MGI:MGI:1858230
    See related
    Ensembl:ENSMUSG00000018974 AllianceGenome:MGI:1858230
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mKIAA0156
    Summary
    Predicted to enable histone binding activity; snRNA binding activity; and ubiquitin-specific protease binding activity. Acts upstream of or within cell morphogenesis; hematopoietic stem cell proliferation; and homeostasis of number of cells. Located in Cajal body. Is expressed in several structures, including genitourinary system; heart; hemolymphoid system; liver; and lung. Orthologous to human SART3 (spliceosome associated factor 3, U4/U6 recycling protein). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 20.4), CNS E14 (RPKM 11.1) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    5 F; 5 55.55 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (113880505..113910461, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (113742444..113772400, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700069L16 gene Neighboring gene predicted gene, 46919 Neighboring gene STARR-positive B cell enhancer ABC_E2171 Neighboring gene FIC domain containing Neighboring gene STARR-seq mESC enhancer starr_14052 Neighboring gene STARR-positive B cell enhancer ABC_E9260 Neighboring gene 40S ribosomal protein S28 pseudogene Neighboring gene iron-sulfur cluster assembly enzyme Neighboring gene transmembrane protein 119

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Identification of a gene coding for a protein possessing shared tumor epitopes capable of inducing HLA-A24-restricted cytotoxic T lymphocytes in cancer patients. Yang D, et al. Cancer Res, 1999 Aug 15. PMID 10463607
    2. Targeting of U4/U6 small nuclear RNP assembly factor SART3/p110 to Cajal bodies. Stanĕk D, et al. J Cell Biol, 2003 Feb 17. PMID 12578909, Free PMC Article
    3. Mouse homologue of the human SART3 gene encoding tumor-rejection antigen. Harada K, et al. Jpn J Cancer Res, 2000 Feb. PMID 10761712, Free PMC Article
    4. Tip110 Deletion Impaired Embryonic and Stem Cell Development Involving Downregulation of Stem Cell Factors Nanog, Oct4, and Sox2. Whitmill A, et al. Stem Cells, 2017 Jul. PMID 28436127
    5. TIP110/p110nrb/SART3/p110 regulation of hematopoiesis through CMYC. Liu Y, et al. Blood, 2011 May 26. PMID 21447833, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (5)  1 citation
    • Endonuclease-mediated (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables U6 snRNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables U6atac snRNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables histone binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin-specific protease binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cell morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within hematopoietic stem cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within homeostasis of number of cells IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in nucleosome assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in spliceosomal snRNP assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in spliceosomal tri-snRNP complex assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in transcription elongation-coupled chromatin remodeling ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of ASAP complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Cajal body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Cajal body ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of U4/U6 snRNP ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of U6atac snRNP ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    squamous cell carcinoma antigen recognized by T-cells 3
    Names
    SART-3
    mSART-3
    tumor-rejection antigen SART3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001356621.1 → NP_001343550.1  squamous cell carcinoma antigen recognized by T-cells 3 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC132939
      Conserved Domains (4) summary
      cd12391
      Location:723 → 796
      RRM1_SART3; RNA recognition motif 1 in squamous cell carcinoma antigen recognized by T-cells 3 (SART3) and similar proteins
      cd12392
      Location:817 → 897
      RRM2_SART3; RNA recognition motif 2 in squamous cell carcinoma antigen recognized by T-cells 3 (SART3) and similar proteins
      pfam16605
      Location:895 → 953
      LSM_int_assoc; LSM-interacting associated unstructured
      cl26993
      Location:101 → 479
      Suf; Suppressor of forked protein (Suf)

    2. NM_001356623.1 → NP_001343552.1  squamous cell carcinoma antigen recognized by T-cells 3 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate splice junction compared to variant 1. The resulting isoform (3) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      AC132939
      Conserved Domains (3) summary
      cd12391
      Location:316 → 389
      RRM1_SART3; RNA recognition motif 1 in squamous cell carcinoma antigen recognized by T-cells 3 (SART3) and similar proteins
      cd12392
      Location:410 → 490
      RRM2_SART3; RNA recognition motif 2 in squamous cell carcinoma antigen recognized by T-cells 3 (SART3) and similar proteins
      cl25617
      Location:488 → 546
      LSM_int_assoc; LSM-interacting associated unstructured

    3. NM_016926.2 → NP_058622.1  squamous cell carcinoma antigen recognized by T-cells 3 isoform 2

      See identical proteins and their annotated locations for NP_058622.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AC132939, AK086398
      Consensus CDS
      CCDS19552.1
      UniProtKB/Swiss-Prot
      Q6ZQI2, Q8BPK9, Q8C3B7, Q8CFU9, Q9JLI8
      Related
      ENSMUSP00000019118.4, ENSMUST00000019118.8
      Conserved Domains (7) summary
      COG0724
      Location:641 → 858
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      COG5107
      Location:101 → 461
      RNA14; Pre-mRNA 3'-end processing (cleavage and polyadenylation) factor [RNA processing and modification]
      cd12391
      Location:705 → 778
      RRM1_SART3; RNA recognition motif 1 in squamous cell carcinoma antigen recognized by T-cells 3 (SART3) and similar proteins
      cd12392
      Location:799 → 879
      RRM2_SART3; RNA recognition motif 2 in squamous cell carcinoma antigen recognized by T-cells 3 (SART3) and similar proteins
      pfam05391
      Location:944 → 961
      Lsm_interact; Lsm interaction motif
      pfam08424
      Location:334 → 487
      NRDE-2; NRDE-2, necessary for RNA interference
      pfam16605
      Location:877 → 935
      LSM_int_assoc; LSM-interacting associated unstructured

    RNA

    1. NR_151532.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) has several differences compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC132939
      Related
      ENSMUST00000197041.2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      113880505..113910461 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030254699.1 → XP_030110559.1  squamous cell carcinoma antigen recognized by T-cells 3 isoform X2

      Conserved Domains (5) summary
      COG5107
      Location:1 → 323
      RNA14; Pre-mRNA 3'-end processing (cleavage and polyadenylation) factor [RNA processing and modification]
      cd12391
      Location:567 → 640
      RRM1_SART3; RNA recognition motif 1 in squamous cell carcinoma antigen recognized by T-cells 3 (SART3) and similar proteins
      cd12392
      Location:661 → 741
      RRM2_SART3; RNA recognition motif 2 in squamous cell carcinoma antigen recognized by T-cells 3 (SART3) and similar proteins
      pfam05391
      Location:806 → 823
      Lsm_interact; Lsm interaction motif
      pfam16605
      Location:739 → 797
      LSM_int_assoc; LSM-interacting associated unstructured

    2. XM_006530406.1 → XP_006530469.1  squamous cell carcinoma antigen recognized by T-cells 3 isoform X1

      Conserved Domains (5) summary
      COG5107
      Location:1 → 341
      RNA14; Pre-mRNA 3'-end processing (cleavage and polyadenylation) factor [RNA processing and modification]
      cd12391
      Location:585 → 658
      RRM1_SART3; RNA recognition motif 1 in squamous cell carcinoma antigen recognized by T-cells 3 (SART3) and similar proteins
      cd12392
      Location:679 → 759
      RRM2_SART3; RNA recognition motif 2 in squamous cell carcinoma antigen recognized by T-cells 3 (SART3) and similar proteins
      pfam05391
      Location:824 → 841
      Lsm_interact; Lsm interaction motif
      pfam16605
      Location:757 → 815
      LSM_int_assoc; LSM-interacting associated unstructured
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9JLI8.1 GenPept UniProtKB/Swiss-Prot:Q9JLI8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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