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    Polr2k polymerase (RNA) II (DNA directed) polypeptide K [ Mus musculus (house mouse) ]

    Gene ID: 17749, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Polr2kprovided by MGI
    Official Full Name
    polymerase (RNA) II (DNA directed) polypeptide Kprovided by MGI
    Primary source
    MGI:MGI:102725
    See related
    Ensembl:ENSMUSG00000045996 AllianceGenome:MGI:102725
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MafY; Mt1a; RPB12; RPABC4; RPB7.0; RPB10alpha; ABC10-alpha
    Summary
    Predicted to enable DNA binding activity; DNA-directed 5'-3' RNA polymerase activity; and zinc ion binding activity. Acts upstream of or within transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of RNA polymerase I complex; RNA polymerase II, core complex; and RNA polymerase III complex. Is expressed in several structures, including cerebral cortex; nose; submandibular gland primordium; thymus primordium; and tooth. Orthologous to human POLR2K (RNA polymerase II, I and III subunit K). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in CNS E11.5 (RPKM 21.0), liver E14 (RPKM 19.6) and 17 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    15 B3.1; 15 14.46 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (36174156..36177158)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (36174010..36177012)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene regulator of G-protein signalling 22 Neighboring gene STARR-seq mESC enhancer starr_38352 Neighboring gene heterogeneous nuclear ribonucleoprotein C pseudogene Neighboring gene F-box protein 43 Neighboring gene predicted gene, 22979 Neighboring gene sperm associated antigen 1 Neighboring gene predicted gene, 23754 Neighboring gene predicted gene, 41293

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Metallothionein-I overexpression alters brain inflammation and stimulates brain repair in transgenic mice with astrocyte-targeted interleukin-6 expression. Penkowa M, et al. Glia, 2003 May. PMID 12673834
    2. Interactions of the zinc-regulated factor (ZiRF1) with the mouse metallothionein Ia promoter. Remondelli P, et al. Biochem J, 1997 Apr 1. PMID 9173905, Free PMC Article
    3. cDNA cloning of a mouse factor that activates transcription from a metal response element of the mouse metallothionein-I gene in yeast. Xu C. DNA Cell Biol, 1993 Jul-Aug. PMID 8329119
    4. Importin α7 is essential for zygotic genome activation and early mouse development. Rother F, et al. PLoS One, 2011 Mar 29. PMID 21479251, Free PMC Article
    5. Spatiotemporal regulation of GLI target genes in the mammalian limb bud. Lewandowski JP, et al. Dev Biol, 2015 Oct 1. PMID 26238476, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Metallothionein-I was upregulated by a cryolesion to a higher extent in GFAP-IL-6 transgenic mice, suggesting that it could be related to the neuroprotection afforded by the transgenic expression of IL-6.
      Title: Metallothionein-I overexpression alters brain inflammation and stimulates brain repair in transgenic mice with astrocyte-targeted interleukin-6 expression.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-directed 5'-3' RNA polymerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to RNA polymerase I activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to RNA polymerase II activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to RNA polymerase III activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of DNA-directed RNA polymerase complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of RNA polymerase I complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of RNA polymerase I complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of RNA polymerase II, core complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of RNA polymerase II, core complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of RNA polymerase III complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of RNA polymerase III complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    DNA-directed RNA polymerases I, II, and III subunit RPABC4
    Names
    metallothionein-I gene transcription activator
    NP_001034457.1
    NP_075616.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001039368.2 → NP_001034457.1  DNA-directed RNA polymerases I, II, and III subunit RPABC4 isoform a

      See identical proteins and their annotated locations for NP_001034457.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
      Source sequence(s)
      AK008136, BY646564, CR516049
      Consensus CDS
      CCDS27426.1
      UniProtKB/TrEMBL
      Q8BFX0
      Related
      ENSMUSP00000051968.6, ENSMUST00000057177.7
      Conserved Domains (1) summary
      smart00659
      Location:56 → 99
      RPOLCX; RNA polymerase subunit CX

    2. NM_023127.3 → NP_075616.2  DNA-directed RNA polymerases I, II, and III subunit RPABC4 isoform b

      See identical proteins and their annotated locations for NP_075616.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks part of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (b) has a shorter N-terminus, compared to isoform a.
      Source sequence(s)
      AK003023, AK008136, BY646564, CR516049
      Consensus CDS
      CCDS56980.1
      UniProtKB/Swiss-Prot
      Q63871
      UniProtKB/TrEMBL
      Q545V5, Q9D2S5
      Related
      ENSMUSP00000136975.2, ENSMUST00000180159.8
      Conserved Domains (1) summary
      smart00659
      Location:15 → 58
      RPOLCX; RNA polymerase subunit CX

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      36174156..36177158
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q63871.2 GenPept UniProtKB/Swiss-Prot:Q63871

    Gene LinkOut

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