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    Emc4 ER membrane protein complex subunit 4 [ Mus musculus (house mouse) ]

    Gene ID: 68032, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Emc4provided by MGI
    Official Full Name
    ER membrane protein complex subunit 4provided by MGI
    Primary source
    MGI:MGI:1915282
    See related
    Ensembl:ENSMUSG00000027131 AllianceGenome:MGI:1915282
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tmem85; 2610318K02Rik
    Summary
    Predicted to contribute to membrane insertase activity. Predicted to be involved in protein insertion into ER membrane by stop-transfer membrane-anchor sequence and tail-anchored membrane protein insertion into ER membrane. Predicted to act upstream of or within apoptotic process. Predicted to be integral component of endoplasmic reticulum membrane. Predicted to be part of EMC complex. Is expressed in lung. Orthologous to human EMC4 (ER membrane protein complex subunit 4). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in cerebellum adult (RPKM 57.7), cortex adult (RPKM 48.8) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    2 E3; 2 57.02 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (112193349..112209532, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (112363019..112379476, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E4485 Neighboring gene STARR-positive B cell enhancer ABC_E7845 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:112106464-112106665 Neighboring gene STARR-positive B cell enhancer ABC_E10129 Neighboring gene solute carrier family 12, member 6 Neighboring gene NOP10 ribonucleoprotein Neighboring gene predicted gene, 39908 Neighboring gene STARR-positive B cell enhancer mm9_chr2:112219168-112219469 Neighboring gene katanin p80 subunit B like 1 Neighboring gene STARR-positive B cell enhancer ABC_E5959 Neighboring gene STARR-positive B cell enhancer ABC_E3389 Neighboring gene STARR-positive B cell enhancer ABC_E11150 Neighboring gene ER membrane protein complex subunit 7

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. EMC3 regulates mesenchymal cell survival via control of the mitotic spindle assembly. Tang X, et al. iScience, 2023 Jan 20. PMID 36624844, Free PMC Article
    2. EMC3 coordinates surfactant protein and lipid homeostasis required for respiration. Tang X, et al. J Clin Invest, 2017 Dec 1. PMID 29083321, Free PMC Article
    3. The ER membrane protein complex is a transmembrane domain insertase. Guna A, et al. Science, 2018 Jan 26. PMID 29242231, Free PMC Article
    4. Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies. Murtaza N, et al. Cell Rep, 2022 Nov 22. PMID 36417873
    5. Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors. Kim H, et al. Cell, 2018 Dec 13. PMID 30550785, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    contributes_to membrane insertase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein insertion into ER membrane by stop-transfer membrane-anchor sequence ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in tail-anchored membrane protein insertion into ER membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of EMC complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of EMC complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ER membrane protein complex subunit 4
    Names
    transmembrane protein 85

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001418608.1 → NP_001405537.1  ER membrane protein complex subunit 4 isoform b

      Status: VALIDATED

      Source sequence(s)
      AL683897

    2. NM_001418609.1 → NP_001405538.1  ER membrane protein complex subunit 4 isoform c

      Status: VALIDATED

      Source sequence(s)
      AL683897

    3. NM_001418610.1 → NP_001405539.1  ER membrane protein complex subunit 4 isoform d

      Status: VALIDATED

      Source sequence(s)
      AL683897

    4. NM_001418611.1 → NP_001405540.1  ER membrane protein complex subunit 4 isoform d

      Status: VALIDATED

      Source sequence(s)
      AL683897

    5. NM_001418612.1 → NP_001405541.1  ER membrane protein complex subunit 4 isoform e

      Status: VALIDATED

      Source sequence(s)
      AL683897

    6. NM_001418613.1 → NP_001405542.1  ER membrane protein complex subunit 4 isoform f

      Status: VALIDATED

      Source sequence(s)
      AL683897

    7. NM_001418614.1 → NP_001405543.1  ER membrane protein complex subunit 4 isoform f

      Status: VALIDATED

      Source sequence(s)
      AL683897

    8. NM_001418615.1 → NP_001405544.1  ER membrane protein complex subunit 4 isoform f

      Status: VALIDATED

      Source sequence(s)
      AL683897

    9. NM_001418616.1 → NP_001405545.1  ER membrane protein complex subunit 4 isoform f

      Status: VALIDATED

      Source sequence(s)
      AL683897

    10. NM_001418617.1 → NP_001405546.1  ER membrane protein complex subunit 4 isoform g

      Status: VALIDATED

      Source sequence(s)
      AL683897

    11. NM_026519.4 → NP_080795.1  ER membrane protein complex subunit 4 isoform a

      See identical proteins and their annotated locations for NP_080795.1

      Status: VALIDATED

      Source sequence(s)
      AL683897
      Consensus CDS
      CCDS16553.1
      UniProtKB/Swiss-Prot
      A2AGJ7, Q9CZX9, Q9D1D9
      Related
      ENSMUSP00000028551.4, ENSMUST00000028551.4
      Conserved Domains (1) summary
      pfam06417
      Location:56 → 170
      DUF1077; Protein of unknown function (DUF1077)

    RNA

    1. NR_184785.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL683897

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      112193349..112209532 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030252000.2 → XP_030107860.1  ER membrane protein complex subunit 4 isoform X1

      UniProtKB/Swiss-Prot
      A2AGJ7, Q9CZX9, Q9D1D9
      Conserved Domains (1) summary
      pfam06417
      Location:56 → 170
      DUF1077; Protein of unknown function (DUF1077)

    2. XM_030251999.2 → XP_030107859.1  ER membrane protein complex subunit 4 isoform X1

      UniProtKB/Swiss-Prot
      A2AGJ7, Q9CZX9, Q9D1D9
      Conserved Domains (1) summary
      pfam06417
      Location:56 → 170
      DUF1077; Protein of unknown function (DUF1077)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CZX9.1 GenPept UniProtKB/Swiss-Prot:Q9CZX9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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