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    Tmem11 transmembrane protein 11 [ Mus musculus (house mouse) ]

    Gene ID: 216821, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Tmem11provided by MGI
    Official Full Name
    transmembrane protein 11provided by MGI
    Primary source
    MGI:MGI:2144726
    See related
    Ensembl:ENSMUSG00000043284 AllianceGenome:MGI:2144726
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    5730466P16Rik
    Summary
    Predicted to be involved in inner mitochondrial membrane organization. Located in mitochondrion. Is expressed in cap mesenchyme and renal interstitium. Orthologous to human TMEM11 (transmembrane protein 11). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in ovary adult (RPKM 40.7), adrenal adult (RPKM 32.2) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    11 B2; 11 37.9 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (60755278..60769864, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (60864452..60879038, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene phosphoserine aminotransferase 1 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E8411 Neighboring gene dehydrogenase/reductase 7B Neighboring gene STARR-positive B cell enhancer ABC_E10679 Neighboring gene STARR-seq mESC enhancer starr_29661 Neighboring gene predicted gene, 26534 Neighboring gene N-acetyltransferase domain containing 1 Neighboring gene predicted gene, 39830

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. TMEM11 regulates cardiomyocyte proliferation and cardiac repair via METTL1-mediated m(7)G methylation of ATF5 mRNA. Chen XZ, et al. Cell Death Differ, 2023 Jul. PMID 37286744, Free PMC Article
    2. Penetrance of craniofacial anomalies in mouse models of Smith-Magenis syndrome is modified by genomic sequence surrounding Rai1: not all null alleles are alike. Yan J, et al. Am J Hum Genet, 2007 Mar. PMID 17273973, Free PMC Article
    3. Gene-trap mutagenesis using Mol/MSM-1 embryonic stem cells from MSM/Ms mice. Nakahara M, et al. Mamm Genome, 2013 Jun. PMID 23604909
    4. Tagging genes with cassette-exchange sites. Cobellis G, et al. Nucleic Acids Res, 2005 Mar 1. PMID 15741177, Free PMC Article
    5. Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette. Taniwaki T, et al. Dev Growth Differ, 2005 Apr. PMID 15840001

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TMEM11 regulates cardiomyocyte proliferation and cardiac repair via METTL1-mediated m[7]G methylation of ATF5 mRNA.
      Title: TMEM11 regulates cardiomyocyte proliferation and cardiac repair via METTL1-mediated m(7)G methylation of ATF5 mRNA.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Endonuclease-mediated (4) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in inner mitochondrial membrane organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrion organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrial inner membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    transmembrane protein 11, mitochondrial

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001168507.1 → NP_001161979.1  transmembrane protein 11, mitochondrial isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding region and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      AL596215, CX211768
      Consensus CDS
      CCDS48815.1
      UniProtKB/TrEMBL
      E9Q933
      Related
      ENSMUSP00000128654.2, ENSMUST00000168218.8
      Conserved Domains (1) summary
      pfam14972
      Location:12 → 174
      Mito_morph_reg; Mitochondrial morphogenesis regulator

    2. NM_173453.3 → NP_775655.1  transmembrane protein 11, mitochondrial isoform 1

      See identical proteins and their annotated locations for NP_775655.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AI835409, AK077600, AL596215
      Consensus CDS
      CCDS24801.1
      UniProtKB/Swiss-Prot
      Q5NCT6, Q8BK08
      Related
      ENSMUSP00000059494.6, ENSMUST00000062677.12
      Conserved Domains (1) summary
      pfam14972
      Location:26 → 188
      Mito_morph_reg; Mitochondrial morphogenesis regulator

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      60755278..60769864 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BK08.1 GenPept UniProtKB/Swiss-Prot:Q8BK08

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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