Angptl7 angiopoietin-like 7 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Angptl7provided by MGI
Official Full Name: angiopoietin-like 7provided by MGI
Primary source: MGI:MGI:3605801
See related: Ensembl:ENSMUSG00000028989 AllianceGenome:MGI:3605801
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Predicted to enable identical protein binding activity and signaling receptor binding activity. Predicted to be involved in negative regulation of vasculature development involved in avascular cornea development in camera-type eye and regulation of extracellular matrix organization. Predicted to be located in extracellular region. Predicted to be active in collagen-containing extracellular matrix and extracellular space. Is expressed in brain. Orthologous to human ANGPTL7 (angiopoietin like 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in kidney adult (RPKM 6.5), bladder adult (RPKM 4.1) and 12 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 E2; 4 78.76 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (148579737..148584919, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (148495181..148500462, complement)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ANGPTL7 and Its Role in IOP and Glaucoma.
Title: ANGPTL7 and Its Role in IOP and Glaucoma.
The non-cell-autonomous function of ID1 promotes AML progression via ANGPTL7 from the microenvironment.
Title: The non-cell-autonomous function of ID1 promotes AML progression via ANGPTL7 from the microenvironment.
ANGPTL7, a therapeutic target for increased intraocular pressure and glaucoma.
Title: ANGPTL7, a therapeutic target for increased intraocular pressure and glaucoma.
Angptl7 promotes insulin resistance and type 2 diabetes mellitus by multiple mechanisms including SOCS3-mediated IRS1 degradation.
Title: Angptl7 promotes insulin resistance and type 2 diabetes mellitus by multiple mechanisms including SOCS3-mediated IRS1 degradation.
When MC3T3-E1 cells were exposed to osteogenic medium, there was a significant increase in ANGPTL7, and overexpression of ANGPTL7 markedly promoted cell proliferation, ALP activity, and mineralization.
Title: Effect of ANGPTL7 on Proliferation and Differentiation of MC3T3-E1 Cells.
Angptl7 is a factor that promotes pro-inflammatory responses in macrophages through the P38 MAPK signaling pathway
Title: Angiopoietin-Like Protein 7 Promotes an Inflammatory Phenotype in RAW264.7 Macrophages Through the P38 MAPK Signaling Pathway.
Angptl7 was indispensable for bone marrow microenvironment to support hematopoietic stem cells repopulation
Title: Loss of Angiopoietin-like 7 diminishes the regeneration capacity of hematopoietic stem and progenitor cells.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation
Endonuclease-mediated (6) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables identical protein binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in negative regulation of vasculature development involved in avascular cornea development in camera-type eye	ISO Inferred from Sequence Orthology more info
involved_in regulation of extracellular matrix organization	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in collagen-containing extracellular matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular region	ISO Inferred from Sequence Orthology more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: angiopoietin-related protein 7

Names: angiopoietin-like protein 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001039554.3 → NP_001034643.1 angiopoietin-related protein 7 precursor

See identical proteins and their annotated locations for NP_001034643.1

Status: PROVISIONAL

Source sequence(s)

AL713995

Consensus CDS

CCDS18938.1

UniProtKB/Swiss-Prot

Q8R1Q3

Related

ENSMUSP00000030840.4, ENSMUST00000030840.4

Conserved Domains (1) summary

cd00087
Location:120 → 332

FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...