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    Abcg1 ATP binding cassette subfamily G member 1 [ Mus musculus (house mouse) ]

    Gene ID: 11307, updated on 29-Jun-2021

    Summary

    Official Symbol
    Abcg1provided by MGI
    Official Full Name
    ATP binding cassette subfamily G member 1provided by MGI
    Primary source
    MGI:MGI:107704
    See related
    Ensembl:ENSMUSG00000024030
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Abc; Abc8; Whit; White; AW413978
    Summary
    The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. The human protein is involved in macrophage cholesterol efflux and may regulate cellular lipid homeostasis in other cell types. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in thymus adult (RPKM 31.5), lung adult (RPKM 23.3) and 16 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Abcg1 in Genome Data Viewer
    Location:
    17; 17 A3.3
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (31276668..31336958)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (31057694..31117984)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 17 NC_000083.5 (31194639..31254929)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 41562 Neighboring gene uromodulin-like 1 Neighboring gene trefoil factor 3, intestinal Neighboring gene trefoil factor 2 (spasmolytic protein 1)

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    General gene information

    Markers

    Homology

    Clone Names

    • MGC141022

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ABC-type sterol transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables ABC-type sterol transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ADP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATPase-coupled transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables cholesterol transfer activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables floppase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphatidylcholine floppase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables toxin transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in amyloid precursor protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to high density lipoprotein particle stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cholesterol efflux IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in cholesterol efflux IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cholesterol efflux ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cholesterol homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in cholesterol homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cholesterol metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cholesterol transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in glycoprotein transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in high-density lipoprotein particle remodeling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in intracellular cholesterol transport ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within lipid transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in low-density lipoprotein particle remodeling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of lipid storage IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of macrophage derived foam cell differentiation IC
    Inferred by Curator
    more info
    PubMed 
    involved_in phospholipid efflux ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in phospholipid homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of amyloid-beta formation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cholesterol biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of cholesterol efflux IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of insulin secretion involved in cellular response to glucose stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein secretion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of secretory granule organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cholesterol esterification IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to lipid ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in reverse cholesterol transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    located_in endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in external side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in recycling endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    ATP-binding cassette sub-family G member 1
    Names
    ATP-binding cassette 8
    ATP-binding cassette transporter 8
    ATP-binding cassette, sub-family G (WHITE), member 1
    white protein homolog

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009593.2NP_033723.1  ATP-binding cassette sub-family G member 1

      See identical proteins and their annotated locations for NP_033723.1

      Status: REVIEWED

      Source sequence(s)
      AC167247, AF323659, AK037433, BY296839, CO431055, CV558133
      Consensus CDS
      CCDS28602.1
      UniProtKB/Swiss-Prot
      Q64343
      UniProtKB/TrEMBL
      Q0VDW9
      Related
      ENSMUSP00000024829.7, ENSMUST00000024829.8
      Conserved Domains (1) summary
      TIGR00955
      Location:60666
      3a01204; The Eye Pigment Precursor Transporter (EPP) Family protein

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      31276668..31336958
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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