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    Mfsd11 major facilitator superfamily domain containing 11 [ Mus musculus (house mouse) ]

    Gene ID: 69900, updated on 28-Apr-2024

    Summary

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    Official Symbol
    Mfsd11provided by MGI
    Official Full Name
    major facilitator superfamily domain containing 11provided by MGI
    Primary source
    MGI:MGI:1917150
    See related
    Ensembl:ENSMUSG00000020818 AllianceGenome:MGI:1917150
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2600014M03Rik
    Summary
    Predicted to be located in membrane. Predicted to be integral component of membrane. Is expressed in several structures, including brain; genitourinary system; hemolymphoid system; liver; and spinal cord. Orthologous to human MFSD11 (major facilitator superfamily domain containing 11). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in mammary gland adult (RPKM 25.4), testis adult (RPKM 24.4) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    11 E2; 11 81.49 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (116743037..116766486)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (116852211..116875660)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene matrix-remodelling associated 7 Neighboring gene STARR-seq mESC enhancer starr_31225 Neighboring gene STARR-positive B cell enhancer ABC_E7102 Neighboring gene STARR-positive B cell enhancer ABC_E4018 Neighboring gene STARR-positive B cell enhancer ABC_E2376 Neighboring gene methyltransferase like 23 Neighboring gene jumonji domain containing 6 Neighboring gene serine and arginine-rich splicing factor 2 Neighboring gene STARR-seq mESC enhancer starr_31229 Neighboring gene mannoside acetylglucosaminyltransferase 5, isoenzyme B Neighboring gene STARR-seq mESC enhancer starr_31231 Neighboring gene predicted gene, 33829 Neighboring gene STARR-seq mESC enhancer starr_31232 Neighboring gene STARR-seq mESC enhancer starr_31233 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:116898528-116898729 Neighboring gene predicted gene 11728

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Characterization of multiple alternative RNAs resulting from antisense transcription of the PR264/SC35 splicing factor gene. Sureau A, et al. Nucleic Acids Res, 1997 Nov 15. PMID 9358160, Free PMC Article
    2. The Putative SLC Transporters Mfsd5 and Mfsd11 Are Abundantly Expressed in the Mouse Brain and Have a Potential Role in Energy Homeostasis. Perland E, et al. PLoS One, 2016. PMID 27272503, Free PMC Article
    3. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
    4. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
    5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (1) 

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC113819

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    UNC93-like protein MFSD11
    Names
    major facilitator superfamily domain-containing protein 11
    protein ET

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001361585.1 → NP_001348514.1  UNC93-like protein MFSD11 isoform 2

      Status: VALIDATED

      Source sequence(s)
      BC079583, BC100547
      Conserved Domains (1) summary
      cl28910
      Location:50 → 248
      MFS; Major Facilitator Superfamily

    2. NM_001361586.1 → NP_001348515.1  UNC93-like protein MFSD11 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL645542
      Conserved Domains (1) summary
      cl28910
      Location:28 → 226
      MFS; Major Facilitator Superfamily

    3. NM_001361587.1 → NP_001348516.1  UNC93-like protein MFSD11 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL645542
      Conserved Domains (1) summary
      cl28910
      Location:50 → 248
      MFS; Major Facilitator Superfamily

    4. NM_178620.4 → NP_848735.1  UNC93-like protein MFSD11 isoform 1

      See identical proteins and their annotated locations for NP_848735.1

      Status: VALIDATED

      Source sequence(s)
      BC088988, BC100547
      Consensus CDS
      CCDS25681.1
      UniProtKB/Swiss-Prot
      A2AA30, A2AA32, B2RQK5, O54844, Q8BJ51, Q8BJ61
      Related
      ENSMUSP00000021173.8, ENSMUST00000021173.14
      Conserved Domains (1) summary
      cd17407
      Location:11 → 435
      MFS_MFSD11; UNC93-like Major facilitator superfamily domain-containing protein 11

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      116743037..116766486
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006534144.5 → XP_006534207.1  UNC93-like protein MFSD11 isoform X1

      See identical proteins and their annotated locations for XP_006534207.1

      UniProtKB/Swiss-Prot
      A2AA30, A2AA32, B2RQK5, O54844, Q8BJ51, Q8BJ61
      Conserved Domains (1) summary
      cd17407
      Location:11 → 435
      MFS_MFSD11; UNC93-like Major facilitator superfamily domain-containing protein 11

    2. XM_006534142.4 → XP_006534205.1  UNC93-like protein MFSD11 isoform X1

      See identical proteins and their annotated locations for XP_006534205.1

      UniProtKB/Swiss-Prot
      A2AA30, A2AA32, B2RQK5, O54844, Q8BJ51, Q8BJ61
      Conserved Domains (1) summary
      cd17407
      Location:11 → 435
      MFS_MFSD11; UNC93-like Major facilitator superfamily domain-containing protein 11

    3. XM_036156971.1 → XP_036012864.1  UNC93-like protein MFSD11 isoform X1

      UniProtKB/Swiss-Prot
      A2AA30, A2AA32, B2RQK5, O54844, Q8BJ51, Q8BJ61
      Related
      ENSMUSP00000123368.3, ENSMUST00000153084.3
      Conserved Domains (1) summary
      cd17407
      Location:11 → 435
      MFS_MFSD11; UNC93-like Major facilitator superfamily domain-containing protein 11

    4. XM_017314745.2 → XP_017170234.1  UNC93-like protein MFSD11 isoform X1

      UniProtKB/Swiss-Prot
      A2AA30, A2AA32, B2RQK5, O54844, Q8BJ51, Q8BJ61
      Conserved Domains (1) summary
      cd17407
      Location:11 → 435
      MFS_MFSD11; UNC93-like Major facilitator superfamily domain-containing protein 11

    5. XM_006534143.5 → XP_006534206.1  UNC93-like protein MFSD11 isoform X1

      See identical proteins and their annotated locations for XP_006534206.1

      UniProtKB/Swiss-Prot
      A2AA30, A2AA32, B2RQK5, O54844, Q8BJ51, Q8BJ61
      Conserved Domains (1) summary
      cd17407
      Location:11 → 435
      MFS_MFSD11; UNC93-like Major facilitator superfamily domain-containing protein 11

    6. XM_036156973.1 → XP_036012866.1  UNC93-like protein MFSD11 isoform X4

      Conserved Domains (1) summary
      cl28910
      Location:50 → 248
      MFS; Major Facilitator Superfamily

    7. XM_006534146.5 → XP_006534209.1  UNC93-like protein MFSD11 isoform X3

      Conserved Domains (1) summary
      cd17407
      Location:4 → 387
      MFS_MFSD11; UNC93-like Major facilitator superfamily domain-containing protein 11

    8. XM_006534145.4 → XP_006534208.1  UNC93-like protein MFSD11 isoform X2

      Conserved Domains (1) summary
      cd17407
      Location:11 → 408
      MFS_MFSD11; UNC93-like Major facilitator superfamily domain-containing protein 11

    9. XM_036156972.1 → XP_036012865.1  UNC93-like protein MFSD11 isoform X4

      Conserved Domains (1) summary
      cl28910
      Location:50 → 248
      MFS; Major Facilitator Superfamily
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BJ51.1 GenPept UniProtKB/Swiss-Prot:Q8BJ51

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