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    Chpt1 choline phosphotransferase 1 [ Mus musculus (house mouse) ]

    Gene ID: 212862, updated on 23-Jun-2021

    Summary

    Official Symbol
    Chpt1provided by MGI
    Official Full Name
    choline phosphotransferase 1provided by MGI
    Primary source
    MGI:MGI:2384841
    See related
    Ensembl:ENSMUSG00000060002
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Expression
    Broad expression in subcutaneous fat pad adult (RPKM 37.3), kidney adult (RPKM 34.7) and 18 other tissues See more
    Orthologs
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    Genomic context

    See Chpt1 in Genome Data Viewer
    Location:
    10; 10 C1
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (88305376..88339855, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (88469513..88503970, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (87935558..87966715, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 40733 Neighboring gene N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits Neighboring gene synaptonemal complex protein 3 Neighboring gene myosin binding protein C, slow-type Neighboring gene ribosomal protein L7A pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (2) 

    Pathways from PubChem

    General gene information

    Markers

    Homology

    Clone Names

    • MGC28885

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables diacylglycerol cholinephosphotransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables diacylglycerol cholinephosphotransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphotransferase activity, for other substituted phosphate groups IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    cholinephosphotransferase 1
    Names
    diabetic nephropathy-associated gene transcript 1
    diacylglycerol cholinephosphotransferase 1
    NP_001140162.1
    NP_659056.3
    XP_006513517.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001146690.1NP_001140162.1  cholinephosphotransferase 1 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer protein (isoform 1).
      Source sequence(s)
      AW823530, BE137041, BE650891, BY341208, CJ177670, EL958096
      Consensus CDS
      CCDS48665.1
      UniProtKB/TrEMBL
      D3YU39
      Related
      ENSMUSP00000112708.2, ENSMUST00000117440.8
      Conserved Domains (1) summary
      cl00453
      Location:25337
      CDP-OH_P_transf; CDP-alcohol phosphatidyltransferase
    2. NM_144807.3NP_659056.3  cholinephosphotransferase 1 isoform 2

      See identical proteins and their annotated locations for NP_659056.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains a different segment for its 3' coding region and 3' UTR versus variant 1. The resulting protein (isoform 2) has a shorter and distinct C-terminus when it is compared to isoform 1.
      Source sequence(s)
      AC125486, AK032497, CJ177670
      Consensus CDS
      CCDS24112.1
      UniProtKB/Swiss-Prot
      Q8C025
      Related
      ENSMUSP00000020253.9, ENSMUST00000020253.15
      Conserved Domains (1) summary
      cl00453
      Location:25337
      CDP-OH_P_transf; CDP-alcohol phosphatidyltransferase

    RNA

    1. NR_027477.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses a different splice site in the 3' coding region, compared to variant 1. Uncertainty about the protein-coding capacity of the transcript exists because the transcript is a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AW823530, BE650891, BY341208, CJ177670, EL958096

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      88305376..88339855 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006513454.3XP_006513517.1  cholinephosphotransferase 1 isoform X1

      Conserved Domains (1) summary
      cl00453
      Location:25213
      CDP-OH_P_transf; CDP-alcohol phosphatidyltransferase

    RNA

    1. XR_004936148.1 RNA Sequence

    2. XR_003948646.2 RNA Sequence

    3. XR_003948645.2 RNA Sequence

    4. XR_003948644.2 RNA Sequence

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