Rad51c RAD51 paralog C [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rad51cprovided by MGI
Official Full Name: RAD51 paralog Cprovided by MGI
Primary source: MGI:MGI:2150020
See related: Ensembl:ENSMUSG00000007646 AllianceGenome:MGI:2150020
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: R51H3; Rad51l2
Summary: Enables crossover junction endodeoxyribonuclease activity. Involved in telomere maintenance via recombination. Acts upstream of or within meiotic nuclear division and spermatogenesis. Located in nucleus. Is expressed in several structures, including genitourinary system; heart; liver; lung; and spleen. Human ortholog(s) of this gene implicated in Fanconi anemia complementation group O and hereditary breast ovarian cancer syndrome. Orthologous to human RAD51C (RAD51 paralog C). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in testis adult (RPKM 3.5), CNS E11.5 (RPKM 2.8) and 16 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 C; 11 52.08 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (87267471..87295780, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (87376645..87404954, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Hypomorphic Brca2 and Rad51c double mutant mice display Fanconi anemia, cancer and polygenic replication stress.
Title: Hypomorphic Brca2 and Rad51c double mutant mice display Fanconi anemia, cancer and polygenic replication stress.
we demonstrate that miR-222 up-regulation, directly regulates Rad51c expression negatively, and impairs homologous recombination of double-strand break DNA repair during the initiation stage of cell transformation.
Title: Post-transcriptional regulation of Rad51c by miR-222 contributes cellular transformation.
Similar to other BC models, Rad51c/p53 double-mutant mouse mammary tumors also reveal a propensity for genomic instability, but lack the focal amplification of the Met locus or distinct mutational signatures reported for other HR genes
Title: Rad51c- and Trp53-double-mutant mouse model reveals common features of homologous recombination-deficient breast cancers.
a critical synergy between Rad51c and Trp53 in tumour progression and provide a predictable in vivo model system for studying mechanisms of Rad51c-mediated carcinogenesis
Title: Loss of Rad51c accelerates tumourigenesis in sebaceous glands of Trp53-mutant mice.
These results imply that adequate expression of Rad51C in mammalian cells is essential for maintaining genomic stability and sister chromatid cohesion to prevent malignant transformation.
Title: Rad51C is essential for embryonic development and haploinsufficiency causes increased DNA damage sensitivity and genomic instability.
DNA replication licensing factor MCM2 and DNA mismatch repair (MMR) protein MSH2 were confirmed to be present in co-precipitations with MmRAD51C.
Title: The interaction profile of homologous recombination repair proteins RAD51C, RAD51D and XRCC2 as determined by proteomic analysis.
Rad51c mutation in DH-cis mice promoted the development of tumors of specialized sebaceous glands and suppressed tumors characteristic of Trp53 mutation. In addition, DH-cis females developed tumors significantly earlier than any other group.
Title: Loss of Rad51c leads to embryonic lethality and modulation of Trp53-dependent tumorigenesis in mice.
RAD51C has a late role in meiotic recombination.
Title: RAD51C deficiency in mice results in early prophase I arrest in males and sister chromatid separation at metaphase II in females.
the RAD51C-XRCC3-associated Holliday junction resolvase complex associates with crossovers and may play an essential role in the resolution of recombination intermediates prior to chromosome segregation
Title: Role of RAD51C and XRCC3 in genetic recombination and DNA repair.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (2)
Targeted (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

UniSTS:488216 (e-PCR)
- UniSTS:488216

AU048745 (e-PCR)
- UniSTS:145195

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP-dependent DNA damage sensor activity	IEA Inferred from Electronic Annotation more info
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables crossover junction DNA endonuclease activity	IMP Inferred from Mutant Phenotype more info	PubMed
contributes_to crossover junction DNA endonuclease activity	ISO Inferred from Sequence Orthology more info
contributes_to four-way junction DNA binding	IBA Inferred from Biological aspect of Ancestor more info
contributes_to four-way junction DNA binding	ISO Inferred from Sequence Orthology more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA damage response	IEA Inferred from Electronic Annotation more info
involved_in DNA recombination	ISO Inferred from Sequence Orthology more info
involved_in DNA repair	ISO Inferred from Sequence Orthology more info
involved_in double-strand break repair via homologous recombination	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within female meiosis sister chromatid cohesion	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within male meiosis I	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in meiotic DNA recombinase assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of G2/M transition of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in reciprocal meiotic recombination	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within reciprocal meiotic recombination	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within spermatogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in telomere maintenance via recombination	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
part_of Holliday junction resolvase complex	IC Inferred by Curator more info	PubMed
part_of Holliday junction resolvase complex	ISO Inferred from Sequence Orthology more info
part_of Rad51B-Rad51C-Rad51D-XRCC2 complex	IBA Inferred from Biological aspect of Ancestor more info
part_of Rad51B-Rad51C-Rad51D-XRCC2 complex	ISO Inferred from Sequence Orthology more info
part_of Rad51C-XRCC3 complex	IBA Inferred from Biological aspect of Ancestor more info
part_of Rad51C-XRCC3 complex	ISO Inferred from Sequence Orthology more info
located_in cell junction	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in replication fork	IBA Inferred from Biological aspect of Ancestor more info
located_in replication fork	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: DNA repair protein RAD51 homolog 3

Names: RAD51 homolog C; RAD51-like protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001291440.2 → NP_001278369.1 DNA repair protein RAD51 homolog 3 isoform 1

Status: VALIDATED

Source sequence(s)

AL596130, AL669902

Consensus CDS

CCDS79013.1

UniProtKB/Swiss-Prot

Q924H5

Related

ENSMUSP00000007790.5, ENSMUST00000007790.11

Conserved Domains (2) summary

cd01123
Location:109 → 356

Rad51_DMC1_radA; Rad51_DMC1_radA,B. This group of recombinases includes the eukaryotic proteins RAD51, RAD55/57 and the meiosis-specific protein DMC1, and the archaeal proteins radA and radB. They are closely related to the bacterial RecA group. Rad51 proteins catalyze a ...

pfam08423
Location:95 → 358

Rad51; Rad51
NM_053269.4 → NP_444499.1 DNA repair protein RAD51 homolog 3 isoform 2

See identical proteins and their annotated locations for NP_444499.1

Status: VALIDATED

Source sequence(s)

AL596130, AL669902, BC090648, BY720217

Consensus CDS

CCDS25212.1

UniProtKB/Swiss-Prot

B2KGK7, Q5SX32, Q8C653, Q924H5

UniProtKB/TrEMBL

F2Z433

Related

ENSMUSP00000064079.7, ENSMUST00000067692.13

Conserved Domains (2) summary

PRK04301
Location:12 → 340

radA; DNA repair and recombination protein RadA; Validated

cd01123
Location:91 → 338

Rad51_DMC1_radA; Rad51_DMC1_radA,B. This group of recombinases includes the eukaryotic proteins RAD51, RAD55/57 and the meiosis-specific protein DMC1, and the archaeal proteins radA and radB. They are closely related to the bacterial RecA group. Rad51 proteins catalyze a ...

RNA

NR_156495.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AK136204, AL596130, AL669902

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

87267471..87295780 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036156234.1 → XP_036012127.1 DNA repair protein RAD51 homolog 3 isoform X1
XM_036156235.1 → XP_036012128.1 DNA repair protein RAD51 homolog 3 isoform X2

Conserved Domains (2) summary

PRK04301
Location:12 → 166

radA; DNA repair and recombination protein RadA; Validated

cl38936
Location:109 → 226

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases