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    Cmip c-Maf inducing protein [ Mus musculus (house mouse) ]

    Gene ID: 74440, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Cmipprovided by MGI
    Official Full Name
    c-Maf inducing proteinprovided by MGI
    Primary source
    MGI:MGI:1921690
    See related
    Ensembl:ENSMUSG00000034390 AllianceGenome:MGI:1921690
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4933407C03Rik; 5830471E12Rik
    Summary
    Acts upstream of or within in utero embryonic development. Predicted to be located in cytoplasm and nucleus. Predicted to be active in cytosol and nucleoplasm. Orthologous to human CMIP (c-Maf inducing protein). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E18 (RPKM 37.9), whole brain E14.5 (RPKM 37.0) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    8 E1; 8 63.87 cM
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (117983758..118188245)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (117257019..117461506)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_22807 Neighboring gene STARR-positive B cell enhancer ABC_E8266 Neighboring gene beta-carotene oxygenase 1 Neighboring gene STARR-positive B cell enhancer ABC_E2275 Neighboring gene STARR-positive B cell enhancer mm9_chr8:119748493-119748794 Neighboring gene giant axonal neuropathy Neighboring gene STARR-seq mESC enhancer starr_22810 Neighboring gene STARR-seq mESC enhancer starr_22812 Neighboring gene STARR-seq mESC enhancer starr_22816 Neighboring gene predicted gene, 51554 Neighboring gene STARR-seq mESC enhancer starr_22817 Neighboring gene predicted gene, 39260 Neighboring gene microRNA 7077 Neighboring gene microRNA 7078 Neighboring gene STARR-positive B cell enhancer ABC_E11399 Neighboring gene phospholipase C, gamma 2 Neighboring gene short chain dehydrogenase/reductase family 42E, member 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Inhibition of nephrin activation by c-mip through Csk-Cbp-Fyn axis plays a critical role in Angiotensin II-induced podocyte damage. Yu L, et al. Cell Signal, 2013 Mar. PMID 23200848
    2. CMIP is a negative regulator of T cell signaling. Oniszczuk J, et al. Cell Mol Immunol, 2020 Oct. PMID 31395948, Free PMC Article
    3. c-mip down-regulates NF-κB activity and promotes apoptosis in podocytes. Ory V, et al. Am J Pathol, 2012 Jun. PMID 22507836
    4. Dnmt1/Tet2-mediated changes in Cmip methylation regulate the development of nonalcoholic fatty liver disease by controlling the Gbp2-Pparγ-CD36 axis. Lee J, et al. Exp Mol Med, 2023 Jan. PMID 36609599, Free PMC Article
    5. Repression of CMIP transcription by WT1 is relevant to podocyte health. Moktefi A, et al. Kidney Int, 2016 Dec. PMID 27650733

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Dnmt1/Tet2-mediated changes in Cmip methylation regulate the development of nonalcoholic fatty liver disease by controlling the Gbp2-Ppargamma-CD36 axis.
      Title: Dnmt1/Tet2-mediated changes in Cmip methylation regulate the development of nonalcoholic fatty liver disease by controlling the Gbp2-Pparγ-CD36 axis.
    2. CMIP is a negative regulator of T cell signaling.
      Title: CMIP is a negative regulator of T cell signaling.
    3. Unlike the human CMIP gene, only one Wt1 response element was identified in the mouse Cmip proximal promoter located at position -217/-206.
      Title: Repression of CMIP transcription by WT1 is relevant to podocyte health.
    4. the c-mip protein is involve in regulating nephrin phosphorylation through Csk-Cbp/PAG-Fyn signaling pathway.
      Title: Inhibition of nephrin activation by c-mip through Csk-Cbp-Fyn axis plays a critical role in Angiotensin II-induced podocyte damage.
    5. Expression of Cmip in the mouse hippocampus is modulated by a sequence variant (B2 SINE indel) in the 3' UTR of Comt (catechol-O-methyltransferase).
      Title: A transposon in Comt generates mRNA variants and causes widespread expression and behavioral differences among mice.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2)  1 citation
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within in utero embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    C-Maf-inducing protein
    Names
    c-Mip

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163262.1 → NP_001156734.1  C-Maf-inducing protein isoform 1

      See identical proteins and their annotated locations for NP_001156734.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC118207, AC121116, AK016712, AK165728, BX514237, BY243950, BY792820, CA552751
      Consensus CDS
      CCDS52680.1
      UniProtKB/Swiss-Prot
      Q69ZD2, Q8C3N2, Q8K148, Q9D486
      UniProtKB/TrEMBL
      B2RY70
      Related
      ENSMUSP00000130264.2, ENSMUST00000166750.9
      Conserved Domains (3) summary
      cd09293
      Location:594 → 768
      AMN1; Antagonist of mitotic exit network protein 1
      sd00034
      Location:664 → 687
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam00169
      Location:71 → 157
      PH; PH domain

    2. NM_028941.1 → NP_083217.1  C-Maf-inducing protein isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      AC118207, AK016712, AK165728, BX514237, BY243950, CA552751
      Consensus CDS
      CCDS52681.1
      UniProtKB/TrEMBL
      B2RY70
      Related
      ENSMUSP00000092795.5, ENSMUST00000095172.6
      Conserved Domains (2) summary
      cd09293
      Location:506 → 680
      AMN1; Antagonist of mitotic exit network protein 1
      sd00034
      Location:576 → 599
      LRR_AMN1; leucine-rich repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      117983758..118188245
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006531434.4 → XP_006531497.1  C-Maf-inducing protein isoform X2

      UniProtKB/TrEMBL
      B2RY70
      Conserved Domains (2) summary
      cd09293
      Location:518 → 692
      AMN1; Antagonist of mitotic exit network protein 1
      sd00034
      Location:588 → 611
      LRR_AMN1; leucine-rich repeat [structural motif]

    2. XM_011248527.3 → XP_011246829.3  C-Maf-inducing protein isoform X1

      UniProtKB/TrEMBL
      B2RY70
      Conserved Domains (2) summary
      cd09293
      Location:546 → 685
      AMN1; Antagonist of mitotic exit network protein 1
      sd00034
      Location:581 → 604
      LRR_AMN1; leucine-rich repeat [structural motif]

    3. XM_006531436.2 → XP_006531499.1  C-Maf-inducing protein isoform X4

      Conserved Domains (2) summary
      cd09293
      Location:442 → 581
      AMN1; Antagonist of mitotic exit network protein 1
      sd00034
      Location:477 → 500
      LRR_AMN1; leucine-rich repeat [structural motif]

    4. XM_006531435.3 → XP_006531498.1  C-Maf-inducing protein isoform X3

      See identical proteins and their annotated locations for XP_006531498.1

      UniProtKB/TrEMBL
      B2RY70
      Conserved Domains (2) summary
      cd09293
      Location:476 → 615
      AMN1; Antagonist of mitotic exit network protein 1
      sd00034
      Location:511 → 534
      LRR_AMN1; leucine-rich repeat [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D486.3 GenPept UniProtKB/Swiss-Prot:Q9D486

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