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    Inip INTS3 and NABP interacting protein [ Mus musculus (house mouse) ]

    Gene ID: 66209, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Inipprovided by MGI
    Official Full Name
    INTS3 and NABP interacting proteinprovided by MGI
    Primary source
    MGI:MGI:1913459
    See related
    Ensembl:ENSMUSG00000038544 AllianceGenome:MGI:1913459
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ssbip1; 1110054O05Rik; 2610312O17Rik
    Summary
    Predicted to be involved in DNA repair and response to ionizing radiation. Predicted to be located in nucleus and site of double-strand break. Predicted to be part of SOSS complex. Predicted to be active in nucleoplasm. Is expressed in several structures, including brain ventricular layer; submandibular gland primordium; thymus primordium; tooth; and vibrissa. Orthologous to human INIP (INTS3 and NABP interacting protein). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 8.6), thymus adult (RPKM 7.0) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    4 B3; 4 32.81 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (59769637..59783855, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (59769637..59783885, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E835 Neighboring gene STARR-seq mESC enhancer starr_10381 Neighboring gene hydroxysteroid dehydrogenase like 2 Neighboring gene RIKEN cDNA E130308A19 gene Neighboring gene predicted gene, 54283 Neighboring gene STARR-seq mESC enhancer starr_10382 Neighboring gene STARR-positive B cell enhancer ABC_E421 Neighboring gene STARR-seq mESC enhancer starr_10383 Neighboring gene STARR-positive B cell enhancer ABC_E7970 Neighboring gene STARR-positive B cell enhancer ABC_E3493 Neighboring gene STARR-positive B cell enhancer ABC_E6184 Neighboring gene STARR-positive B cell enhancer ABC_E9590 Neighboring gene STARR-positive B cell enhancer ABC_E10237 Neighboring gene sorting nexin family member 30 Neighboring gene STARR-seq mESC enhancer starr_10384 Neighboring gene sorting nexin 2 pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:59891511-59891739 Neighboring gene solute carrier family 46, member 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Characterization of the piRNA complex from rat testes. Lau NC, et al. Science, 2006 Jul 21. PMID 16778019
    2. Functional genomic landscape of cancer-intrinsic evasion of killing by T cells. Lawson KA, et al. Nature, 2020 Oct. PMID 32968282, Free PMC Article
    3. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article
    4. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article
    5. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA damage response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in DNA repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA repair ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in double-strand break repair via homologous recombination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitotic G2/M transition checkpoint ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to ionizing radiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of SOSS complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of SOSS complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in site of double-strand break ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    SOSS complex subunit C
    Names
    SOSS-C
    SSB-interacting protein 1
    sensor of single-strand DNA complex subunit C
    sensor of ssDNA subunit C
    single-stranded DNA-binding protein-interacting protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013577.1 → NP_001013595.1  SOSS complex subunit C

      See identical proteins and their annotated locations for NP_001013595.1

      Status: VALIDATED

      Source sequence(s)
      AK004256, AL806512, BB641174
      Consensus CDS
      CCDS18225.1
      UniProtKB/Swiss-Prot
      B1AX81, B1AX82, Q3TEN1, Q3TXT3, Q8BTC7
      Related
      ENSMUSP00000092673.5, ENSMUST00000095063.11
      Conserved Domains (1) summary
      pfam15925
      Location:18 → 101
      SOSSC; SOSS complex subunit C

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      59769637..59783855 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030253695.2 → XP_030109555.1  SOSS complex subunit C isoform X1

      UniProtKB/TrEMBL
      Z4YLT1
      Related
      ENSMUSP00000103150.2, ENSMUST00000107526.8
      Conserved Domains (1) summary
      pfam15925
      Location:4 → 71
      SOSSC; SOSS complex subunit C
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3TXT3.1 GenPept UniProtKB/Swiss-Prot:Q3TXT3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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