Sycp2 synaptonemal complex protein 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Sycp2provided by MGI
Official Full Name: synaptonemal complex protein 2provided by MGI
Primary source: MGI:MGI:1933281
See related: Ensembl:ENSMUSG00000060445 AllianceGenome:MGI:1933281
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 3830402K23Rik; 4930518F03Rik
Summary: Predicted to enable DNA binding activity. Acts upstream of or within several processes, including fertilization; male genitalia morphogenesis; and meiotic nuclear division. Located in lateral element. Is expressed in meiotic germ cell of ovary and primary oocyte. Human ortholog(s) of this gene implicated in spermatogenic failure 1. Orthologous to human SYCP2 (synaptonemal complex protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in testis adult (RPKM 6.1) and CNS E18 (RPKM 0.3) See more
Orthologs: human all
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Genomic context

Location:: 2 H4; 2 99.81 cM

Exon count:: 43

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (177987088..178051580, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (178345295..178407776, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Using yeast two-hybrid screening, it discovered the surprising finding that the SYCP2 NTR associates well with the centromere. It was reported that the C-terminal region of mSYCP2 was found to be responsible for the association of SYCP3 and SYCP1 for synaptonemal complex (SC) formation.
Title: Synaptonemal complex protein 2 (SYCP2) mediates the association of the centromere with the synaptonemal complex.
SYCP2 are not required for centromere cohesion at the metaphase-I stage in male germ cells.
Title: SYCP2 and SYCP3 are required for cohesin core integrity at diplotene but not for centromere cohesion at the first meiotic division.
SYCP2 is a primary determinant of axial elements and lateral elements and, thus, is required for the incorporation of SYCP3 into synaptonemal complexes.
Title: Mouse SYCP2 is required for synaptonemal complex assembly and chromosomal synapsis during male meiosis.
SYCP2 and SYCP3 proteins function in the specificity of chromatin attachment to the chromosome core
Title: Male mouse meiotic chromosome cores deficient in structural proteins SYCP3 and SYCP2 align by homology but fail to synapse and have possible impaired specificity of chromatin loop attachment.
SYCP2 is a primary determinant of axial/lateral elements (AEs/LEs) and is required for the incorporation of SYCP3 into synaptonemal complexes.
Title: Mouse SYCP2 is required for synaptonemal complex assembly and chromosomal synapsis during male meiosis.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

mScp2 (e-PCR)
- UniSTS:514591

G65197 (e-PCR)
- UniSTS:225878

D2Mit73 (e-PCR), detects polymorphism
- UniSTS:129467

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within animal organ morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell cycle	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell division	IEA Inferred from Electronic Annotation more info
acts_upstream_of ectopic germ cell programmed cell death	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in female meiotic nuclear division	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within female meiotic nuclear division	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within fertilization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within male genitalia morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in male meiotic nuclear division	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within male meiotic nuclear division	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within meiotic cell cycle	IEA Inferred from Electronic Annotation more info
involved_in mitotic G1 phase	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within mitotic G1 phase	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of developmental process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of reproductive process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in chromosome	IEA Inferred from Electronic Annotation more info
is_active_in condensed chromosome, centromeric region	IBA Inferred from Biological aspect of Ancestor more info
is_active_in lateral element	IBA Inferred from Biological aspect of Ancestor more info
located_in lateral element	IDA Inferred from Direct Assay more info	PubMed
located_in lateral element	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	TAS Traceable Author Statement more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in synaptonemal complex	IDA Inferred from Direct Assay more info	PubMed
located_in synaptonemal complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: synaptonemal complex protein 2

Names: SCP-2; synaptonemal complex lateral element protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_177191.3 → NP_796165.2 synaptonemal complex protein 2

See identical proteins and their annotated locations for NP_796165.2

Status: VALIDATED

Source sequence(s)

AL772217, DQ103262

Consensus CDS

CCDS38370.1

UniProtKB/Swiss-Prot

A2AJW2, Q1G7B6, Q9CUU3

Related

ENSMUSP00000079909.4, ENSMUST00000081134.10

Conserved Domains (1) summary

COG4399
Location:43 → 236

YheB; Uncharacterized membrane protein YheB, UPF0754 family [Function unknown]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

177987088..178051580 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006500664.4 → XP_006500727.1 synaptonemal complex protein 2 isoform X2

Conserved Domains (1) summary

pfam18584
Location:53 → 164

SYCP2_SLD; Synaptonemal complex 2 Spt16M-like domain
XM_017319020.3 → XP_017174509.1 synaptonemal complex protein 2 isoform X1

Conserved Domains (2) summary

pfam18581
Location:1 → 85

SYCP2_ARLD; Synaptonemal complex 2 armadillo-repeat-like domain

pfam18584
Location:179 → 290

SYCP2_SLD; Synaptonemal complex 2 Spt16M-like domain