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    Spata16 spermatogenesis associated 16 [ Mus musculus (house mouse) ]

    Gene ID: 70862, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Spata16provided by MGI
    Official Full Name
    spermatogenesis associated 16provided by MGI
    Primary source
    MGI:MGI:1918112
    See related
    Ensembl:ENSMUSG00000039335 AllianceGenome:MGI:1918112
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Nyd-sp12; 4921511F01Rik; 4930503K02Rik
    Summary
    Acts upstream of or within spermatogenesis. Predicted to be located in cytoplasmic vesicle. Predicted to be active in Golgi apparatus. Used to study male infertility. Human ortholog(s) of this gene implicated in spermatogenic failure 6. Orthologous to human SPATA16 (spermatogenesis associated 16). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Restricted expression toward testis adult (RPKM 54.8) See more
    Orthologs
    human all
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    Genomic context

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    Location:
    3 A3; 3 10.74 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (26691769..27037398)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (26637620..26983249)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene cullin 2 pseudogene Neighboring gene predicted gene, 57710 Neighboring gene STARR-seq mESC enhancer starr_07216 Neighboring gene STARR-seq mESC enhancer starr_07217 Neighboring gene STARR-seq mESC enhancer starr_07219 Neighboring gene predicted gene, 32458 Neighboring gene STARR-seq mESC enhancer starr_07220 Neighboring gene STARR-seq mESC enhancer starr_07221 Neighboring gene STARR-seq mESC enhancer starr_07222 Neighboring gene ribosomal protein L3 pseudogene Neighboring gene predicted gene, 25152 Neighboring gene ect2 oncogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Identification and characterization of a novel human testis-specific Golgi protein, NYD-SP12. Xu M, et al. Mol Hum Reprod, 2003 Jan. PMID 12529416
    2. Human Globozoospermia-Related Gene Spata16 Is Required for Sperm Formation Revealed by CRISPR/Cas9-Mediated Mouse Models. Fujihara Y, et al. Int J Mol Sci, 2017 Oct 21. PMID 29065458, Free PMC Article
    3. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
    4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in spermatid development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in spermatogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    spermatogenesis-associated protein 16
    Names
    spermatogenesis-related protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_027583.3 → NP_081859.1  spermatogenesis-associated protein 16 isoform 1

      See identical proteins and their annotated locations for NP_081859.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) differs in the 3' coding region and 3' UTR, compared to variant 2. The resulting isoform (1) has a shorter and distinct C-terminus, compared to isoform 2.
      Source sequence(s)
      BB572700, BC100443
      Consensus CDS
      CCDS38403.1
      UniProtKB/Swiss-Prot
      Q8C636
      Related
      ENSMUSP00000103941.2, ENSMUST00000108305.2
      Conserved Domains (3) summary
      sd00006
      Location:210 → 258
      TPR; TPR repeat [structural motif]
      pfam13414
      Location:178 → 260
      TPR_11; TPR repeat
      pfam15015
      Location:6 → 532
      NYD-SP12_N; Spermatogenesis-associated, N-terminal

    2. NM_029150.4 → NP_083426.1  spermatogenesis-associated protein 16 isoform 2

      See identical proteins and their annotated locations for NP_083426.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) represents the longer transcript and encodes the longer isoform (2).
      Source sequence(s)
      AC108829, AK076628, BC132205
      Consensus CDS
      CCDS17269.1
      UniProtKB/Swiss-Prot
      Q8C636, Q9D5W9
      Related
      ENSMUSP00000043378.5, ENSMUST00000047005.11
      Conserved Domains (3) summary
      sd00006
      Location:210 → 258
      TPR; TPR repeat [structural motif]
      pfam13414
      Location:178 → 260
      TPR_11; TPR repeat
      pfam15015
      Location:6 → 569
      NYD-SP12_N; Spermatogenesis-associated, N-terminal

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      26691769..27037398
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017319720.2 → XP_017175209.1  spermatogenesis-associated protein 16 isoform X1

      Conserved Domains (2) summary
      sd00006
      Location:210 → 258
      TPR; TPR repeat [structural motif]
      pfam15015
      Location:5 → 568
      NYD-SP12_N; Spermatogenesis-associated, N-terminal
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8C636.1 GenPept UniProtKB/Swiss-Prot:Q8C636

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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