Tdrd7 tudor domain containing 7 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tdrd7provided by MGI
Official Full Name: tudor domain containing 7provided by MGI
Primary source: MGI:MGI:2140279
See related: Ensembl:ENSMUSG00000035517 AllianceGenome:MGI:2140279
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: PCTAIRE2BP; 5730495N10Rik
Summary: Predicted to enable mRNA binding activity and protein N-terminus binding activity. Involved in lens fiber cell differentiation; lens morphogenesis in camera-type eye; and spermatogenesis. Acts upstream of or within germ cell development. Located in P granule and chromatoid body. Part of ribonucleoprotein complex. Is expressed in several structures, including central nervous system; olfactory epithelium; retina; and seminiferous tubule. Human ortholog(s) of this gene implicated in cataract 36. Orthologous to human TDRD7 (tudor domain containing 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in testis adult (RPKM 28.4), placenta adult (RPKM 9.5) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 B1; 4 24.48 cM

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (45965335..46034766)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (45965027..46034766)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interferon-stimulated gene TDRD7 interacts with AMPK and inhibits its activation to suppress viral replication and pathogenesis.
Title: Interferon-stimulated gene TDRD7 interacts with AMPK and inhibits its activation to suppress viral replication and pathogenesis.
The Tudor-domain protein TDRD7, mutated in congenital cataract, controls the heat shock protein HSPB1 (HSP27) and lens fiber cell morphology.
Title: The Tudor-domain protein TDRD7, mutated in congenital cataract, controls the heat shock protein HSPB1 (HSP27) and lens fiber cell morphology.
The interferon-inducible protein TDRD7 inhibits AMP-activated protein kinase and thereby restricts autophagy-independent virus replication.
Title: The interferon-inducible protein TDRD7 inhibits AMP-activated protein kinase and thereby restricts autophagy-independent virus replication.
results identify TRPC3 as a pivotal signaling gateway in Ca(2+)-dependent control of cardiac gene expression
Title: Tudor domain containing 7 (Tdrd7) is essential for dynamic ribonucleoprotein (RNP) remodeling of chromatoid bodies during spermatogenesis.
Tdrd7 nullizygosity causes cataract and glaucoma and arrest in spermatogenesis;TDRD7 coimmunoprecipitates with specific lens mRNAs; required for posttranscriptional control of mRNAs critical to normal lens development and RNA granule function
Title: Mutations in the RNA granule component TDRD7 cause cataract and glaucoma.
Tudor-related proteins, which contain multiple repeats of the Tudor domain, constitute an evolutionarily conserved class of nuage components in the germ-line, and their localization or accumulation to nuage is likely conferred by a Tudor domain structure
Title: Tudor-related proteins TDRD1/MTR-1, TDRD6 and TDRD7/TRAP: domain composition, intracellular localization, and function in male germ cells in mice.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation
Chemically induced (ENU) (1)

General gene information

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Markers

Tdrd7 (e-PCR), detects polymorphism
- UniSTS:479291

AI447470 (e-PCR)
- UniSTS:164233

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables mRNA binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in P granule organization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within germ cell development	IDA Inferred from Direct Assay more info	PubMed
involved_in lens fiber cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in lens fiber cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lens fiber cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in lens morphogenesis in camera-type eye	IBA Inferred from Biological aspect of Ancestor more info
involved_in lens morphogenesis in camera-type eye	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lens morphogenesis in camera-type eye	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within multicellular organism development	IEA Inferred from Electronic Annotation more info
involved_in piRNA processing	IBA Inferred from Biological aspect of Ancestor more info
involved_in post-transcriptional regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in spermatogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in spermatogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in P granule	IBA Inferred from Biological aspect of Ancestor more info
located_in P granule	IDA Inferred from Direct Assay more info	PubMed
located_in chromatoid body	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
part_of ribonucleoprotein complex	IDA Inferred from Direct Assay more info	PubMed
located_in ribonucleoprotein granule	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: tudor domain-containing protein 7

Names: PCTAIRE2-binding protein; trap; tudor repeat associator with PCTAIRE 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001290475.1 → NP_001277404.1 tudor domain-containing protein 7 isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longer isoform (1).

Source sequence(s)

AK077641, AK150077, BB619178, BC029689, BY427120, CX563409, CX563831, CX568265

Consensus CDS

CCDS71381.1

UniProtKB/TrEMBL

A0A0A0MQD1

Related

ENSMUSP00000103406.3, ENSMUST00000107777.9

Conserved Domains (5) summary

cd04508
Location:728 → 773

TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...

cd09973
Location:256 → 322

LOTUS_2_TDRD7; The second LOTUS domain on Tudor-containing protein 7 (TDRD7)

cd09974
Location:361 → 425

LOTUS_3_TDRD7; The third LOTUS domain on Tudor-containing protein 7 (TDRD7)

cd09986
Location:38 → 124

LOTUS_1_TDRD7; The first LOTUS domain on Tudor-containing protein 7 (TDRD7)

pfam00567
Location:932 → 1047

TUDOR; Tudor domain
NM_001355189.1 → NP_001342118.1 tudor domain-containing protein 7 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 1. It encodes isoform 2, which has a shorter N-terminus, compared to isoform 1. Variants 2 and 3 encode the same isoform (2).

Source sequence(s)

AK161319, BE950089, BY427120, CF736406, CN539534, CX566254

Consensus CDS

CCDS18142.1

UniProtKB/Swiss-Prot

B1AWG7, B1AWH5, Q8K1H1, Q8R181

Conserved Domains (4) summary

cd09973
Location:223 → 289

LOTUS_2_TDRD7; The second LOTUS domain on Tudor-containing protein 7 (TDRD7)

cd09974
Location:328 → 392

LOTUS_3_TDRD7; The third LOTUS domain on Tudor-containing protein 7 (TDRD7)

cd09986
Location:5 → 91

LOTUS_1_TDRD7; The first LOTUS domain on Tudor-containing protein 7 (TDRD7)

pfam00567
Location:903 → 1013

TUDOR; Tudor domain
NM_146142.2 → NP_666254.1 tudor domain-containing protein 7 isoform 2

See identical proteins and their annotated locations for NP_666254.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 1. It encodes isoform 2, which has a shorter N-terminus, compared to isoform 1. Variants 2 and 3 encode the same isoform (2).

Source sequence(s)

BC029689, BY427120, BY783424

Consensus CDS

CCDS18142.1

UniProtKB/Swiss-Prot

B1AWG7, B1AWH5, Q8K1H1, Q8R181

Related

ENSMUSP00000099993.2, ENSMUST00000102929.2

Conserved Domains (4) summary

cd09973
Location:223 → 289

LOTUS_2_TDRD7; The second LOTUS domain on Tudor-containing protein 7 (TDRD7)

cd09974
Location:328 → 392

LOTUS_3_TDRD7; The third LOTUS domain on Tudor-containing protein 7 (TDRD7)

cd09986
Location:5 → 91

LOTUS_1_TDRD7; The first LOTUS domain on Tudor-containing protein 7 (TDRD7)

pfam00567
Location:903 → 1013

TUDOR; Tudor domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000070.7 Reference GRCm39 C57BL/6J

Range

45965335..46034766

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006537518.2 → XP_006537581.1 tudor domain-containing protein 7 isoform X2

Conserved Domains (4) summary

cd09973
Location:256 → 322

LOTUS_2_TDRD7; The second LOTUS domain on Tudor-containing protein 7 (TDRD7)

cd09974
Location:361 → 425

LOTUS_3_TDRD7; The third LOTUS domain on Tudor-containing protein 7 (TDRD7)

cd09986
Location:38 → 124

LOTUS_1_TDRD7; The first LOTUS domain on Tudor-containing protein 7 (TDRD7)

pfam00567
Location:676 → 795

TUDOR; Tudor domain
XM_030253050.2 → XP_030108910.1 tudor domain-containing protein 7 isoform X3

Conserved Domains (4) summary

cd09973
Location:223 → 289

LOTUS_2_TDRD7; The second LOTUS domain on Tudor-containing protein 7 (TDRD7)

cd09974
Location:328 → 392

LOTUS_3_TDRD7; The third LOTUS domain on Tudor-containing protein 7 (TDRD7)

cd09986
Location:5 → 91

LOTUS_1_TDRD7; The first LOTUS domain on Tudor-containing protein 7 (TDRD7)

pfam00567
Location:643 → 762

TUDOR; Tudor domain
XM_030253051.2 → XP_030108911.1 tudor domain-containing protein 7 isoform X4

Conserved Domains (2) summary

cd09974
Location:55 → 119

LOTUS_3_TDRD7; The third LOTUS domain on Tudor-containing protein 7 (TDRD7)

pfam00567
Location:630 → 740

TUDOR; Tudor domain
XM_030253049.2 → XP_030108909.1 tudor domain-containing protein 7 isoform X1

UniProtKB/Swiss-Prot

B1AWG7, B1AWH5, Q8K1H1, Q8R181

Conserved Domains (4) summary

cd09973
Location:223 → 289

LOTUS_2_TDRD7; The second LOTUS domain on Tudor-containing protein 7 (TDRD7)

cd09974
Location:328 → 392

LOTUS_3_TDRD7; The third LOTUS domain on Tudor-containing protein 7 (TDRD7)

cd09986
Location:5 → 91

LOTUS_1_TDRD7; The first LOTUS domain on Tudor-containing protein 7 (TDRD7)

pfam00567
Location:903 → 1013

TUDOR; Tudor domain
XM_006537519.2 → XP_006537582.1 tudor domain-containing protein 7 isoform X5

Conserved Domains (2) summary

cd09974
Location:3 → 67

LOTUS_3_TDRD7; The third LOTUS domain on Tudor-containing protein 7 (TDRD7)

pfam00567
Location:578 → 688

TUDOR; Tudor domain