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    Dmgdh dimethylglycine dehydrogenase precursor [ Mus musculus (house mouse) ]

    Gene ID: 74129, updated on 23-Jun-2021

    Summary

    Official Symbol
    Dmgdhprovided by MGI
    Official Full Name
    dimethylglycine dehydrogenase precursorprovided by MGI
    Primary source
    MGI:MGI:1921379
    See related
    Ensembl:ENSMUSG00000042102
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AI787269; 1200014D15Rik
    Summary
    This gene encodes an enzyme involved in the catabolism of choline, catalyzing the oxidative demethylation of dimethylglycine to form sarcosine. The enzyme is found as a monomer in the mitochondrial matrix, and uses flavin adenine dinucleotide and folate as cofactors. [provided by RefSeq, Jul 2013]
    Expression
    Biased expression in liver adult (RPKM 68.1), liver E18 (RPKM 28.7) and 3 other tissues See more
    Orthologs
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    Genomic context

    See Dmgdh in Genome Data Viewer
    Location:
    13; 13 C3
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (93810944..93889331)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (93674436..93752823)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 13 NC_000079.5 (94444391..94522778)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene betaine-homocysteine methyltransferase Neighboring gene betaine-homocysteine methyltransferase 2 Neighboring gene expressed sequence AW495222 Neighboring gene predicted gene, 41021 Neighboring gene arylsulfatase B Neighboring gene microRNA 5624

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    Pathways from PubChem

    General gene information

    Markers

    Homology

    Clone Names

    • MGC107623

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables dimethylglycine dehydrogenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables dimethylglycine dehydrogenase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables flavin adenine dinucleotide binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables folic acid binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables oxidoreductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in choline catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in tetrahydrofolate interconversion ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    is_active_in mitochondrial matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    dimethylglycine dehydrogenase, mitochondrial
    Names
    ME2GLYDH
    NP_083048.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_028772.3NP_083048.1  dimethylglycine dehydrogenase, mitochondrial precursor

      See identical proteins and their annotated locations for NP_083048.1

      Status: VALIDATED

      Source sequence(s)
      AC131739, CT030023
      Consensus CDS
      CCDS26690.1
      UniProtKB/Swiss-Prot
      Q9DBT9
      Related
      ENSMUSP00000039663.7, ENSMUST00000048001.8
      Conserved Domains (6) summary
      COG0404
      Location:481850
      GcvT; Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]
      COG0665
      Location:40428
      DadA; Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism]
      pfam01571
      Location:475738
      GCV_T; Aminomethyltransferase folate-binding domain
      pfam08669
      Location:746838
      GCV_T_C; Glycine cleavage T-protein C-terminal barrel domain
      pfam16350
      Location:410465
      FAO_M; FAD dependent oxidoreductase central domain
      cl21454
      Location:3883
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      93810944..93889331
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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