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    Spaca7 sperm acrosome associated 7 [ Mus musculus (house mouse) ]

    Gene ID: 78634, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Spaca7provided by MGI
    Official Full Name
    sperm acrosome associated 7provided by MGI
    Primary source
    MGI:MGI:1925884
    See related
    Ensembl:ENSMUSG00000010435 AllianceGenome:MGI:1925884
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1700094C09Rik
    Summary
    Acts upstream of or within negative regulation of cell adhesion and single fertilization. Located in acrosomal vesicle. Orthologous to human SPACA7 (sperm acrosome associated 7). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Restricted expression toward testis adult (RPKM 51.2) See more
    Orthologs
    human all
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    Genomic context

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    Location:
    8 A1.1; 8 5.73 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (12623038..12650744)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (12573036..12600739)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_20739 Neighboring gene predicted gene, 33532 Neighboring gene STARR-seq mESC enhancer starr_20743 Neighboring gene predicted gene, 53397 Neighboring gene STARR-seq mESC enhancer starr_20744 Neighboring gene tubulin, gamma complex component 3 Neighboring gene STARR-seq mESC enhancer starr_20746 Neighboring gene RIKEN cDNA 4931415C17 gene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. SPACA7 is a novel male germ cell-specific protein localized to the sperm acrosome that is involved in fertilization in mice. Nguyen EB, et al. Biol Reprod, 2014 Jan. PMID 24307706, Free PMC Article
    2. Identification of a new mouse sperm acrosome-associated protein. Korfanty J, et al. Reproduction, 2012 Jun. PMID 22495889
    3. The periphilin 1-like BFAR isoform 3 is highly expressed in transcriptionally silent oocytes and involved in RNA metabolism. Mrowiec K, et al. Biochim Biophys Acta Mol Cell Res, 2021 Sep. PMID 34175335
    4. Genome engineering uncovers 54 evolutionarily conserved and testis-enriched genes that are not required for male fertility in mice. Miyata H, et al. Proc Natl Acad Sci U S A, 2016 Jul 12. PMID 27357688, Free PMC Article
    5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC58425

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    acts_upstream_of cell adhesion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of cell adhesion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within single fertilization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in acrosomal vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in acrosomal vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    sperm acrosome-associated protein 7
    Names
    protein SPACA7

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357297.2 → NP_001344226.1  sperm acrosome-associated protein 7 isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AC161505
      Consensus CDS
      CCDS90371.1
      UniProtKB/TrEMBL
      I6L9C9
      Related
      ENSMUSP00000147552.2, ENSMUST00000209428.2
      Conserved Domains (1) summary
      pfam15307
      Location:19 → 122
      SPACA7; Sperm acrosome-associated protein 7

    2. NM_024279.4 → NP_077241.1  sperm acrosome-associated protein 7 isoform 1 precursor

      See identical proteins and their annotated locations for NP_077241.1

      Status: VALIDATED

      Source sequence(s)
      AC161505
      Consensus CDS
      CCDS40222.1
      UniProtKB/Swiss-Prot
      Q9D2S4
      UniProtKB/TrEMBL
      A0A1B0GRZ1
      Related
      ENSMUSP00000010579.7, ENSMUST00000010579.8
      Conserved Domains (1) summary
      pfam15307
      Location:19 → 130
      SPACA7; Sperm acrosome-associated protein 7

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      12623038..12650744
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D2S4.1 GenPept UniProtKB/Swiss-Prot:Q9D2S4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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