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    Hsd17b3 hydroxysteroid (17-beta) dehydrogenase 3 [ Mus musculus (house mouse) ]

    Gene ID: 15487, updated on 22-Aug-2021

    Summary

    Official Symbol
    Hsd17b3provided by MGI
    Official Full Name
    hydroxysteroid (17-beta) dehydrogenase 3provided by MGI
    Primary source
    MGI:MGI:107177
    See related
    Ensembl:ENSMUSG00000033122
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Expression
    Restricted expression toward testis adult (RPKM 6.2) See more
    Orthologs
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    Genomic context

    See Hsd17b3 in Genome Data Viewer
    Location:
    13; 13 B3
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (64206088..64237076, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (64058274..64089262, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 13 NC_000079.5 (64159582..64190509, complement)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein L10A pseudogene Neighboring gene predicted gene, 30999 Neighboring gene solute carrier family 35, member D2 Neighboring gene zinc finger protein 367

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables estradiol 17-beta-dehydrogenase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables oxidoreductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables testosterone 17-beta-dehydrogenase (NADP+) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables testosterone 17-beta-dehydrogenase (NADP+) activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables testosterone dehydrogenase (NAD+) activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in male genitalia development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in steroid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in steroid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in testosterone biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    testosterone 17-beta-dehydrogenase 3
    Names
    17(beta)HSD type 3
    17-beta-HSD 3
    17-beta-hydroxysteroid dehydrogenase type 3
    estradiol 17-beta-dehydrogenase 2
    testicular 17-beta-hydroxysteroid dehydrogenase
    NP_032317.2
    XP_006517171.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008291.3NP_032317.2  testosterone 17-beta-dehydrogenase 3

      See identical proteins and their annotated locations for NP_032317.2

      Status: VALIDATED

      Source sequence(s)
      BB041573, BB621153, U66827
      Consensus CDS
      CCDS26594.1
      UniProtKB/Swiss-Prot
      P70385
      Related
      ENSMUSP00000132011.2, ENSMUST00000166224.8
      Conserved Domains (2) summary
      cd05356
      Location:44280
      17beta-HSD1_like_SDR_c; 17-beta-hydroxysteroid dehydrogenases (17beta-HSDs) types -1, -3, and -12, -like, classical (c) SDRs
      pfam00106
      Location:45236
      adh_short; short chain dehydrogenase

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      64206088..64237076 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006517108.3XP_006517171.1  testosterone 17-beta-dehydrogenase 3 isoform X1

      Conserved Domains (1) summary
      cd05356
      Location:86268
      17beta-HSD1_like_SDR_c; 17-beta-hydroxysteroid dehydrogenases (17beta-HSDs) types -1, -3, and -12, -like, classical (c) SDRs
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