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    Rbmx RNA binding motif protein, X chromosome [ Mus musculus (house mouse) ]

    Gene ID: 19655, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Rbmxprovided by MGI
    Official Full Name
    RNA binding motif protein, X chromosomeprovided by MGI
    Primary source
    MGI:MGI:1343044
    See related
    Ensembl:ENSMUSG00000031134 AllianceGenome:MGI:1343044
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    hnRNP G
    Summary
    Predicted to enable several functions, including chromatin binding activity; identical protein binding activity; and nucleic acid binding activity. Predicted to be involved in several processes, including RNA metabolic process; cellular response to interleukin-1; and regulation of RNA metabolic process. Predicted to act upstream of or within RNA splicing and mRNA processing. Predicted to be located in euchromatin; extracellular exosome; and nucleus. Predicted to be part of catalytic step 2 spliceosome and supraspliceosomal complex. Is expressed in several structures, including central nervous system; female reproductive system; gut; sensory organ; and thymus. Human ortholog(s) of this gene implicated in syndromic X-linked intellectual disability Shashi type. Orthologous to human RBMX (RNA binding motif protein X-linked). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in CNS E14 (RPKM 55.1), CNS E11.5 (RPKM 51.1) and 20 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    X A6; X 31.64 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (56428708..56438405, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (57383348..57393046, complement)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene CD40 ligand Neighboring gene Rac/Cdc42 guanine nucleotide exchange factor 6 Neighboring gene STARR-positive B cell enhancer ABC_E7690 Neighboring gene STARR-seq mESC enhancer starr_47212 Neighboring gene STARR-positive B cell enhancer ABC_E7691 Neighboring gene CapStarr-seq enhancer MGSCv37_chrX:54563182-54563369 Neighboring gene STARR-seq mESC enhancer starr_47213 Neighboring gene STARR-seq mESC enhancer starr_47214 Neighboring gene small nucleolar RNA, C/D box 61 Neighboring gene transmembrane 9 superfamily member 5 Neighboring gene G protein-coupled receptor 101

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Transcriptional control of CBX5 by the RNA binding proteins RBMX and RBMXL1 maintains chromatin state in myeloid leukemia. Prieto C, et al. Nat Cancer, 2021 Jul. PMID 34458856, Free PMC Article
    2. RBMY evolved on the Y chromosome from a ubiquitously transcribed X-Y identical gene. Mazeyrat S, et al. Nat Genet, 1999 Jul. PMID 10391207
    3. RBMX is a novel hepatic transcriptional regulator of SREBP-1c gene response to high-fructose diet. Takemoto T, et al. FEBS Lett, 2007 Jan 23. PMID 17188681
    4. SAFB1, an RBMX-binding protein, is a newly identified regulator of hepatic SREBP-1c gene. Omura Y, et al. BMB Rep, 2009 Apr 30. PMID 19403048
    5. Evolutionary strata on the mouse X chromosome correspond to strata on the human X chromosome. Sandstedt SA, et al. Genome Res, 2004 Feb. PMID 14762062, Free PMC Article

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These results indicate a major role for SAFB1 in the activation of Srebp-1c through its interaction with RBMX.
      Title: SAFB1, an RBMX-binding protein, is a newly identified regulator of hepatic SREBP-1c gene.
    2. RBMX may control SREBP-1c expression in mouse liver in response to high-fructose diet.
      Title: RBMX is a novel hepatic transcriptional regulator of SREBP-1c gene response to high-fructose diet.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (3) 
    • Endonuclease-mediated (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables chromatin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables mRNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables single-stranded RNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to interleukin-1 ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA splice site recognition ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in membrane protein ectodomain proteolysis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of alternative mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of postsynapse organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of catalytic step 2 spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of euchromatin ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in postsynaptic density ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of spliceosomal complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of supraspliceosomal complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    RNA-binding motif protein, X chromosome
    Names
    heterogeneous nuclear ribonucleoprotein G

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001166623.2 → NP_001160095.1  RNA-binding motif protein, X chromosome

      See identical proteins and their annotated locations for NP_001160095.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses a different splice site in the 5' UTR versus variant 1. Variants 1, 3, 4, and 5 all encode the same protein.
      Source sequence(s)
      AL672106
      Consensus CDS
      CCDS30153.1
      UniProtKB/Swiss-Prot
      Q8C2U6, Q9R0Y0, Q9WV02
      UniProtKB/TrEMBL
      A0A2I3BRL8
      Related
      ENSMUSP00000110374.2, ENSMUST00000114726.8
      Conserved Domains (3) summary
      PRK14086
      Location:167 → 306
      dnaA; chromosomal replication initiator protein DnaA
      pfam08081
      Location:173 → 217
      RBM1CTR; RBM1CTR (NUC064) family
      cd12382
      Location:7 → 86
      RRM_RBMX_like; RNA recognition motif (RRM) found in heterogeneous nuclear ribonucleoprotein G (hnRNP G), Y chromosome RNA recognition motif 1 (hRBMY), testis-specific heterogeneous nuclear ribonucleoprotein G-T (hnRNP G-T) and similar proteins

    2. NM_001425953.1 → NP_001412882.1  RNA-binding motif protein, X chromosome

      Status: VALIDATED

      Source sequence(s)
      AL672106
      UniProtKB/Swiss-Prot
      Q8C2U6, Q9R0Y0, Q9WV02

    3. NM_001425954.1 → NP_001412883.1  RNA-binding motif protein, X chromosome

      Status: VALIDATED

      Source sequence(s)
      AL672106
      UniProtKB/Swiss-Prot
      Q8C2U6, Q9R0Y0, Q9WV02

    4. NM_011252.5 → NP_035382.1  RNA-binding motif protein, X chromosome

      See identical proteins and their annotated locations for NP_035382.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) is the more frequently occurring transcript. Variants 1, 3, 4, and 5 all encode the same protein.
      Source sequence(s)
      AL672106
      Consensus CDS
      CCDS30153.1
      UniProtKB/Swiss-Prot
      Q8C2U6, Q9R0Y0, Q9WV02
      UniProtKB/TrEMBL
      A0A2I3BRL8
      Related
      ENSMUSP00000110378.2, ENSMUST00000114730.8
      Conserved Domains (3) summary
      PRK14086
      Location:167 → 306
      dnaA; chromosomal replication initiator protein DnaA
      pfam08081
      Location:173 → 217
      RBM1CTR; RBM1CTR (NUC064) family
      cd12382
      Location:7 → 86
      RRM_RBMX_like; RNA recognition motif (RRM) found in heterogeneous nuclear ribonucleoprotein G (hnRNP G), Y chromosome RNA recognition motif 1 (hRBMY), testis-specific heterogeneous nuclear ribonucleoprotein G-T (hnRNP G-T) and similar proteins

    RNA

    1. NR_029425.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has alternate 3' sequence, as compared to variant 1. The transcript is a nonsense-mediated mRNA decay (NMD) candidate, probably not making a protein.
      Source sequence(s)
      AL672106

    2. NR_189635.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL672106

    3. NR_189636.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL672106

    4. NR_189637.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL672106

    5. NR_189638.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL672106

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      56428708..56438405 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036161864.1 → XP_036017757.1  RNA-binding motif protein, X chromosome isoform X1

      UniProtKB/Swiss-Prot
      Q8C2U6, Q9R0Y0, Q9WV02
      UniProtKB/TrEMBL
      A0A2I3BRL8
      Conserved Domains (3) summary
      PRK14086
      Location:167 → 306
      dnaA; chromosomal replication initiator protein DnaA
      pfam08081
      Location:173 → 217
      RBM1CTR; RBM1CTR (NUC064) family
      cd12382
      Location:7 → 86
      RRM_RBMX_like; RNA recognition motif (RRM) found in heterogeneous nuclear ribonucleoprotein G (hnRNP G), Y chromosome RNA recognition motif 1 (hRBMY), testis-specific heterogeneous nuclear ribonucleoprotein G-T (hnRNP G-T) and similar proteins

    2. XM_036161865.1 → XP_036017758.1  RNA-binding motif protein, X chromosome isoform X1

      UniProtKB/Swiss-Prot
      Q8C2U6, Q9R0Y0, Q9WV02
      UniProtKB/TrEMBL
      A0A2I3BRL8
      Conserved Domains (3) summary
      PRK14086
      Location:167 → 306
      dnaA; chromosomal replication initiator protein DnaA
      pfam08081
      Location:173 → 217
      RBM1CTR; RBM1CTR (NUC064) family
      cd12382
      Location:7 → 86
      RRM_RBMX_like; RNA recognition motif (RRM) found in heterogeneous nuclear ribonucleoprotein G (hnRNP G), Y chromosome RNA recognition motif 1 (hRBMY), testis-specific heterogeneous nuclear ribonucleoprotein G-T (hnRNP G-T) and similar proteins
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9WV02.1 GenPept UniProtKB/Swiss-Prot:Q9WV02

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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