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    Anxa1 annexin A1 [ Mus musculus (house mouse) ]

    Gene ID: 16952, updated on 5-Jul-2021

    Summary

    Official Symbol
    Anxa1provided by MGI
    Official Full Name
    annexin A1provided by MGI
    Primary source
    MGI:MGI:96819
    See related
    Ensembl:ENSMUSG00000024659
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Lp; Anx; Lpc; Lpc1; Anx-1; Lpc-1; Anx-A1; C430014K04Rik
    Expression
    Biased expression in bladder adult (RPKM 55.7), liver E18 (RPKM 42.1) and 14 other tissues See more
    Orthologs
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    Genomic context

    See Anxa1 in Genome Data Viewer
    Location:
    19 B; 19 13.83 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (20350798..20368035, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (20373434..20390671, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 19 NC_000085.5 (20447924..20465161, complement)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 22684 Neighboring gene predicted gene, 52403 Neighboring gene RIKEN cDNA 1500015L24 gene Neighboring gene predicted gene, 32689

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1)  1 citation
    • Endonuclease-mediated (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA/DNA annealing activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables calcium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables calcium-dependent phospholipid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables calcium-dependent phospholipid binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables calcium-dependent protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables double-stranded DNA helicase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables phospholipase A2 inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables phospholipase A2 inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables phospholipase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables phospholipid binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    contributes_to single-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables single-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to single-stranded RNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in DNA duplex unwinding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in DNA duplex unwinding ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in actin cytoskeleton reorganization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in actin cytoskeleton reorganization ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within adaptive immune response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in alpha-beta T cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in alpha-beta T cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in arachidonic acid secretion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within arachidonic acid secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cell surface receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in cell surface receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to glucocorticoid stimulus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in cellular response to glucocorticoid stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular response to glucocorticoid stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to hydrogen peroxide IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in cellular response to hydrogen peroxide ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to vascular endothelial growth factor stimulus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in cellular response to vascular endothelial growth factor stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in endocrine pancreas development IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in estrous cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in gliogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in granulocyte chemotaxis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in granulocyte chemotaxis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in hepatocyte differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within immune system process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in inflammatory response IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within innate immune response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in insulin secretion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in insulin secretion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in keratinocyte differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in keratinocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in monocyte chemotaxis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in myoblast migration involved in skeletal muscle regeneration IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in myoblast migration involved in skeletal muscle regeneration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of T-helper 2 cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in negative regulation of T-helper 2 cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in negative regulation of exocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of interleukin-8 production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of phospholipase A2 activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in negative regulation of phospholipase A2 activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of protein secretion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in neutrophil clearance IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in neutrophil clearance ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in neutrophil homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in neutrophil homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in peptide cross-linking ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in phagocytosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of G1/S transition of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of G1/S transition of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of T cell proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in positive regulation of T cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of T-helper 1 cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in positive regulation of T-helper 1 cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell migration involved in sprouting angiogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in positive regulation of cell migration involved in sprouting angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of interleukin-2 production IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in positive regulation of interleukin-2 production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of neutrophil apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in positive regulation of neutrophil apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of prostaglandin biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in positive regulation of prostaglandin biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of vesicle fusion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in positive regulation of vesicle fusion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of wound healing IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in positive regulation of wound healing ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in prolactin secretion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in prolactin secretion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in prostate gland development IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within regulation of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of cell shape IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in regulation of cell shape ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of hormone secretion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in regulation of hormone secretion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of inflammatory response IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in regulation of inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of interleukin-1 production IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in regulation of interleukin-1 production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of leukocyte migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in regulation of leukocyte migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to X-ray IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in response to drug IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in response to estradiol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in response to interleukin-1 IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in response to peptide hormone IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    colocalizes_with actin filament ISO
    Inferred from Sequence Orthology
    more info
     
    located_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cilium IEA
    Inferred from Electronic Annotation
    more info
     
    located_in collagen-containing extracellular matrix HDA PubMed 
    located_in cornified envelope ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in endosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extrinsic component of external side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extrinsic component of membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in lateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mast cell granule ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrial membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in motile cilium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in sarcolemma IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in synaptic membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    annexin A1
    Names
    annexin I
    annexin-1
    calpactin II
    calpactin-2
    chromobindin-9
    lipocortin 1
    lipocortin I
    p35
    phospholipase A2 inhibitory protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010730.2NP_034860.2  annexin A1

      See identical proteins and their annotated locations for NP_034860.2

      Status: PROVISIONAL

      Source sequence(s)
      AK167612
      Consensus CDS
      CCDS29692.1
      UniProtKB/Swiss-Prot
      P10107
      UniProtKB/TrEMBL
      Q4FJV4
      Related
      ENSMUSP00000025561.8, ENSMUST00000025561.8
      Conserved Domains (1) summary
      pfam00191
      Location:118183
      Annexin; Annexin

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      20350798..20368035 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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