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    Akr1c14 aldo-keto reductase family 1, member C14 [ Mus musculus (house mouse) ]

    Gene ID: 105387, updated on 6-May-2021

    Summary

    Official Symbol
    Akr1c14provided by MGI
    Official Full Name
    aldo-keto reductase family 1, member C14provided by MGI
    Primary source
    MGI:MGI:2145458
    See related
    Ensembl:ENSMUSG00000033715
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AW557061; 9030611N15Rik
    Expression
    Biased expression in liver adult (RPKM 28.6), liver E18 (RPKM 11.5) and 8 other tissues See more
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    Genomic context

    See Akr1c14 in Genome Data Viewer
    Location:
    13; 13 A1
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (4099015..4140569)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (4048991..4090560)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 13 NC_000079.5 (4058837..4089668)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene urocortin 3 Neighboring gene aldo-keto reductase family 1, member C13 pseudogene Neighboring gene aldo-keto reductase family 1, member C18 Neighboring gene solute carrier family 23 (nucleobase transporters), member 2 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables alditol:NADP+ 1-oxidoreductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables androsterone dehydrogenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables androsterone dehydrogenase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables bile acid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables ketosteroid monooxygenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables steroid dehydrogenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables steroid dehydrogenase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in daunorubicin metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in doxorubicin metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in progesterone metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in prostaglandin metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in steroid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    3-alpha-hydroxysteroid dehydrogenase
    Names
    3-alpha-hydroxysteroid dehydrogenase type 1
    NP_598833.1
    XP_030102973.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_134072.2NP_598833.1  3-alpha-hydroxysteroid dehydrogenase

      See identical proteins and their annotated locations for NP_598833.1

      Status: VALIDATED

      Source sequence(s)
      AC122840
      Consensus CDS
      CCDS26218.1
      UniProtKB/TrEMBL
      Q91WT7
      Related
      ENSMUSP00000045394.7, ENSMUST00000041768.7
      Conserved Domains (1) summary
      cd19108
      Location:6308
      AKR_AKR1C1-35; AKR1C family of aldo-keto reductase (AKR)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      4099015..4140569
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030247113.2XP_030102973.1  3-alpha-hydroxysteroid dehydrogenase isoform X1

      Related
      ENSMUSP00000112664.3, ENSMUST00000118717.10
      Conserved Domains (1) summary
      cd19108
      Location:6308
      AKR_AKR1C1-35; AKR1C family of aldo-keto reductase (AKR)
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