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    Zfyve9 zinc finger, FYVE domain containing 9 [ Mus musculus (house mouse) ]

    Gene ID: 230597, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Zfyve9provided by MGI
    Official Full Name
    zinc finger, FYVE domain containing 9provided by MGI
    Primary source
    MGI:MGI:2652838
    See related
    Ensembl:ENSMUSG00000034557 AllianceGenome:MGI:2652838
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    NSP; SARA; Madhip; SMADIP
    Summary
    Predicted to enable 1-phosphatidylinositol binding activity; SMAD binding activity; and protein domain specific binding activity. Predicted to be involved in endosomal transport and transforming growth factor beta receptor signaling pathway. Predicted to act upstream of or within regulation of transforming growth factor beta receptor signaling pathway. Predicted to be located in cytosol and intracellular membrane-bounded organelle. Predicted to be part of protein-containing complex. Predicted to be active in early endosome membrane. Is expressed in several structures, including genitourinary system; heart; liver; lung; and spleen. Orthologous to human ZFYVE9 (zinc finger FYVE-type containing 9). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in cerebellum adult (RPKM 7.6), cortex adult (RPKM 4.3) and 24 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    4 C7; 4 50.64 cM
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (108494663..108642514, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (108637466..108781269, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E1036 Neighboring gene PRP38 pre-mRNA processing factor 38 (yeast) domain containing A Neighboring gene origin recognition complex, subunit 1 Neighboring gene predicted gene 12743 Neighboring gene coiled-coil and C2 domain containing 1B Neighboring gene ribosomal protein L9 pseudogene Neighboring gene predicted gene, 53266 Neighboring gene STARR-seq mESC enhancer starr_11051 Neighboring gene STARR-seq mESC enhancer starr_11052 Neighboring gene basic transcription factor 3-like 4 Neighboring gene STARR-positive B cell enhancer mm9_chr4:108520274-108520575 Neighboring gene thioredoxin domain containing 12 (endoplasmic reticulum) Neighboring gene KTI12 homolog, chromatin associated

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Sustained BMP signaling in osteoblasts stimulates bone formation by promoting angiogenesis and osteoblast differentiation. Zhang F, et al. J Bone Miner Res, 2009 Jul. PMID 19257813, Free PMC Article
    2. CCR1 plays a critical role in modulating pain through hematopoietic and non-hematopoietic cells. Lewis ND, et al. PLoS One, 2014. PMID 25170619, Free PMC Article
    3. The FYVE domain of Smad Anchor for Receptor Activation (SARA) is required to prevent skin carcinogenesis, but not in mouse development. Chang HM, et al. PLoS One, 2014. PMID 25170969, Free PMC Article
    4. SARA regulates neuronal migration during neocortical development through L1 trafficking. Mestres I, et al. Development, 2016 Sep 1. PMID 27471254, Free PMC Article
    5. Cytoplasmic PML function in TGF-beta signalling. Lin HK, et al. Nature, 2004 Sep 9. PMID 15356634

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1)  1 citation
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • E030027L17

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 1-phosphatidylinositol binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables SMAD binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in endosomal transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of transforming growth factor beta receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in transforming growth factor beta receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transforming growth factor beta receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in early endosome membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in early endosome membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger FYVE domain-containing protein 9
    Names
    MAD, mothers against decapentaplegic homolog interacting protein, receptor activation anchor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001347163.2 → NP_001334092.1  zinc finger FYVE domain-containing protein 9 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL607070, AL626783, AL671909
      Consensus CDS
      CCDS84772.1
      UniProtKB/TrEMBL
      A2A8R0
      Conserved Domains (3) summary
      cd15729
      Location:662 → 729
      FYVE_endofin; FYVE domain found in endofin and similar proteins
      pfam11409
      Location:745 → 783
      SARA; Smad anchor for receptor activation (SARA)
      pfam11979
      Location:1020 → 1372
      DUF3480; Domain of unknown function (DUF3480)

    2. NM_001384118.1 → NP_001371047.1  zinc finger FYVE domain-containing protein 9 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL607070, AL626783, AL671909
      UniProtKB/TrEMBL
      A2A8R0
      Related
      ENSMUSP00000102268.2, ENSMUST00000106657.8
      Conserved Domains (3) summary
      cd15729
      Location:662 → 729
      FYVE_endofin; FYVE domain found in endofin and similar proteins
      pfam11409
      Location:745 → 783
      SARA; Smad anchor for receptor activation (SARA)
      pfam11979
      Location:1020 → 1372
      DUF3480; Domain of unknown function (DUF3480)

    3. NM_001426209.1 → NP_001413138.1  zinc finger FYVE domain-containing protein 9 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL607070, AL626783, AL671909
      UniProtKB/TrEMBL
      A8Y5G5

    4. NM_001426210.1 → NP_001413139.1  zinc finger FYVE domain-containing protein 9 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL607070, AL626783, AL671909

    5. NM_001426211.1 → NP_001413140.1  zinc finger FYVE domain-containing protein 9 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AL607070, AL626783, AL671909

    6. NM_183300.4 → NP_899123.2  zinc finger FYVE domain-containing protein 9 isoform 2

      See identical proteins and their annotated locations for NP_899123.2

      Status: VALIDATED

      Source sequence(s)
      AL607070, AL626783, AL671909
      Consensus CDS
      CCDS38834.1
      UniProtKB/TrEMBL
      A0S860
      Related
      ENSMUSP00000039852.8, ENSMUST00000042185.8
      Conserved Domains (3) summary
      pfam11409
      Location:54 → 92
      SARA; Smad anchor for receptor activation (SARA)
      pfam11979
      Location:329 → 681
      DUF3480; Domain of unknown function (DUF3480)
      cl22851
      Location:7 → 38
      PHD_SF; PHD finger superfamily

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      108494663..108642514 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006502986.5 → XP_006503049.1  zinc finger FYVE domain-containing protein 9 isoform X1

      Conserved Domains (3) summary
      cd15729
      Location:696 → 763
      FYVE_endofin; FYVE domain found in endofin and similar proteins
      pfam11409
      Location:779 → 817
      SARA; Smad anchor for receptor activation (SARA)
      pfam11979
      Location:1054 → 1406
      DUF3480; Domain of unknown function (DUF3480)

    2. XM_006502988.5 → XP_006503051.1  zinc finger FYVE domain-containing protein 9 isoform X3

      Conserved Domains (2) summary
      cd15729
      Location:696 → 763
      FYVE_endofin; FYVE domain found in endofin and similar proteins
      pfam11979
      Location:995 → 1347
      DUF3480; Domain of unknown function (DUF3480)

    3. XM_030253438.2 → XP_030109298.1  zinc finger FYVE domain-containing protein 9 isoform X2

      Conserved Domains (3) summary
      cd15729
      Location:696 → 763
      FYVE_endofin; FYVE domain found in endofin and similar proteins
      pfam11409
      Location:779 → 817
      SARA; Smad anchor for receptor activation (SARA)
      pfam11979
      Location:1054 → 1379
      DUF3480; Domain of unknown function (DUF3480)
    Nucleotide Protein Strain
    Heading Accession and Version

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