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    Recql RecQ protein-like [ Mus musculus (house mouse) ]

    Gene ID: 19691, updated on 8-Jul-2021

    Summary

    Official Symbol
    Recqlprovided by MGI
    Official Full Name
    RecQ protein-likeprovided by MGI
    Primary source
    MGI:MGI:103021
    See related
    Ensembl:ENSMUSG00000030243
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    RecQ; RecQ1
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 4.8), CNS E14 (RPKM 3.9) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Recql in Genome Data Viewer
    Location:
    6 G2; 6 73.91 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (142296068..142332826, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (142350342..142387100, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (142310420..142335607, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene solute carrier organic anion transporter family, member 1a5 Neighboring gene islet amyloid polypeptide Neighboring gene 60S ribosomal protein L18 pseudogene Neighboring gene pyridine nucleotide-disulphide oxidoreductase domain 1 Neighboring gene golgi transport 1B Neighboring gene spexin hormone

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 3'-5' DNA helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP-dependent DNA/DNA annealing activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables ATP-dependent DNA/DNA annealing activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA helicase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables four-way junction helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables helicase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in DNA duplex unwinding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in DNA recombination IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in DNA repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in DNA unwinding involved in DNA replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in double-strand break repair via homologous recombination IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in chromosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    ATP-dependent DNA helicase Q1
    Names
    DNA-dependent ATPase Q1
    recQ protein-like 1
    NP_001191835.1
    NP_001191836.1
    NP_001342440.1
    NP_075529.2
    XP_011239875.1
    XP_017176957.1
    XP_030111131.1
    XP_036021858.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001204906.1NP_001191835.1  ATP-dependent DNA helicase Q1 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR and uses an alternate splice site in the 3' coding region, compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC102125, AC142413
      Consensus CDS
      CCDS57466.1
      UniProtKB/TrEMBL
      E9Q3N0
      Related
      ENSMUSP00000098394.4, ENSMUST00000100832.10
      Conserved Domains (5) summary
      TIGR00614
      Location:81543
      recQ_fam; ATP-dependent DNA helicase, RecQ family
      cd00079
      Location:285417
      HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
      pfam00270
      Location:93268
      DEAD; DEAD/DEAH box helicase
      pfam16124
      Location:422478
      RecQ_Zn_bind; RecQ zinc-binding
      cl09632
      Location:484576
      RQC; RQC domain
    2. NM_001204907.1NP_001191836.1  ATP-dependent DNA helicase Q1 isoform 3

      See identical proteins and their annotated locations for NP_001191836.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 3' UTR and uses an alternate splice site in the 3' coding region, compared to variant 1. The encoded isoform (3) is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC102125, AK137589, AK138325
      Consensus CDS
      CCDS57465.1
      UniProtKB/Swiss-Prot
      Q9Z129
      UniProtKB/TrEMBL
      Q3UUK0
      Related
      ENSMUSP00000032370.7, ENSMUST00000032370.13
      Conserved Domains (1) summary
      TIGR00614
      Location:81543
      recQ_fam; ATP-dependent DNA helicase, RecQ family
    3. NM_001355511.1NP_001342440.1  ATP-dependent DNA helicase Q1 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1, and encodes isoform 1. Variants 1 and 4 encode the same protein (isoform 1).
      Source sequence(s)
      AC102125, AC142413
      Consensus CDS
      CCDS39695.1
      Conserved Domains (1) summary
      TIGR00614
      Location:81543
      recQ_fam; ATP-dependent DNA helicase, RecQ family
    4. NM_023042.3NP_075529.2  ATP-dependent DNA helicase Q1 isoform 1

      See identical proteins and their annotated locations for NP_075529.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1). Variants 1 and 4 encode the same protein (isoform 1).
      Source sequence(s)
      AC102125, AK137589, AK164344
      Consensus CDS
      CCDS39695.1
      UniProtKB/Swiss-Prot
      Q9Z129
      Related
      ENSMUSP00000107434.3, ENSMUST00000111803.9
      Conserved Domains (1) summary
      TIGR00614
      Location:81543
      recQ_fam; ATP-dependent DNA helicase, RecQ family

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      142296068..142332826 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030255271.2XP_030111131.1  ATP-dependent DNA helicase Q1 isoform X3

      Conserved Domains (1) summary
      TIGR00614
      Location:81543
      recQ_fam; ATP-dependent DNA helicase, RecQ family
    2. XM_011241573.2XP_011239875.1  ATP-dependent DNA helicase Q1 isoform X2

      See identical proteins and their annotated locations for XP_011239875.1

      Conserved Domains (1) summary
      TIGR00614
      Location:81543
      recQ_fam; ATP-dependent DNA helicase, RecQ family
    3. XM_036165965.1XP_036021858.1  ATP-dependent DNA helicase Q1 isoform X2

      Conserved Domains (1) summary
      TIGR00614
      Location:81543
      recQ_fam; ATP-dependent DNA helicase, RecQ family
    4. XM_017321468.2XP_017176957.1  ATP-dependent DNA helicase Q1 isoform X1

      UniProtKB/Swiss-Prot
      Q9Z129
      Conserved Domains (1) summary
      TIGR00614
      Location:81543
      recQ_fam; ATP-dependent DNA helicase, RecQ family
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