Depdc1b DEP domain containing 1B [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Depdc1bprovided by MGI
Official Full Name: DEP domain containing 1Bprovided by MGI
Primary source: MGI:MGI:2145425
See related: Ensembl:ENSMUSG00000021697 AllianceGenome:MGI:2145425
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: XTP1; 9830132O03
Summary: Predicted to enable GTPase activator activity. Predicted to be involved in cell migration and positive regulation of Wnt signaling pathway. Is expressed in genital tubercle; limb; and limb mesenchyme. Orthologous to human DEPDC1B (DEP domain containing 1B). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in liver E14 (RPKM 4.2), liver E14.5 (RPKM 3.8) and 12 other tissues See more
Orthologs: human all
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Genomic context

Location:: 13 D2.1; 13 59.69 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	13	NC_000079.7 (108452592..108526100)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	13	NC_000079.6 (108316014..108389566)

Chromosome 13 - NC_000079.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Circ_0005276 Promotes Prostate Cancer Progression Through the Crosstalk of miR-128-3p/DEPDC1B Axis.
Title: Circ_0005276 Promotes Prostate Cancer Progression Through the Crosstalk of miR-128-3p/DEPDC1B Axis.
DEPDC1B plays a central role in myoblasts by driving proliferation and preventing precocious myogenic differentiation during skeletal myogenesis in both mouse and human.
Title: DEPDC1B is a key regulator of myoblast proliferation in mouse and man.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)

General gene information

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Markers

D13Mit170 (e-PCR), detects polymorphism
- UniSTS:126987

AW260467 (e-PCR)
- UniSTS:180599

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables GTPase activator activity	IEA Inferred from Electronic Annotation more info
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in cell migration	ISO Inferred from Sequence Orthology more info
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: DEP domain-containing protein 1B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001418947.1 → NP_001405876.1 DEP domain-containing protein 1B isoform 2

Status: VALIDATED

Source sequence(s)

AC161252, CT030256
NM_001418948.1 → NP_001405877.1 DEP domain-containing protein 1B isoform 3

Status: VALIDATED

Source sequence(s)

AC161252, CT030256
NM_178683.5 → NP_848798.1 DEP domain-containing protein 1B isoform 1

See identical proteins and their annotated locations for NP_848798.1

Status: VALIDATED

Source sequence(s)

AC161252, CT030256

Consensus CDS

CCDS26762.1

UniProtKB/Swiss-Prot

Q810T1, Q8BH88, Q8BZ67

UniProtKB/TrEMBL

A7MCV2

Related

ENSMUSP00000059291.6, ENSMUST00000051594.12

Conserved Domains (2) summary

cd04405
Location:177 → 400

RhoGAP_BRCC3-like; RhoGAP_BRCC3-like: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of BRCC3-like proteins. This subgroup also contains two groups of closely related proteins, BRCC3 and DEPDC7, which both contain a C-terminal RhoGAP-like domain ...

cl02442
Location:15 → 106

DEP; DEP domain, named after Dishevelled, Egl-10, and Pleckstrin, where this domain was first discovered. The function of this domain is still not clear, but it is believed to be important for the membrane association of the signaling proteins in which it is ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000079.7 Reference GRCm39 C57BL/6J

Range

108452592..108526100

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006517614.5 → XP_006517677.1 DEP domain-containing protein 1B isoform X3

Conserved Domains (1) summary

cd04405
Location:28 → 251

RhoGAP_BRCC3-like; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of BRCC3-like proteins. This subgroup also contains two groups of closely related proteins, BRCC3 and DEPDC7, which both contain a C-terminal RhoGAP-like domain and an N-terminal ...