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    Rerg RAS-like, estrogen-regulated, growth-inhibitor [ Mus musculus (house mouse) ]

    Gene ID: 232441, updated on 3-Aug-2021

    Summary

    Official Symbol
    Rergprovided by MGI
    Official Full Name
    RAS-like, estrogen-regulated, growth-inhibitorprovided by MGI
    Primary source
    MGI:MGI:2665139
    See related
    Ensembl:ENSMUSG00000030222
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Expression
    Broad expression in adrenal adult (RPKM 26.0), bladder adult (RPKM 12.7) and 16 other tissues See more
    Orthologs
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    Genomic context

    See Rerg in Genome Data Viewer
    Location:
    6; 6 G1
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (137031822..137147494, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (137054825..137170496, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (137003346..137119017, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene phosphodiesterase 6H, cGMP-specific, cone, gamma Neighboring gene predicted gene, 30055 Neighboring gene predicted gene, 52923 Neighboring gene predicted gene, 38914 Neighboring gene protein tyrosine phosphatase, receptor type, O Neighboring gene predicted gene, 52924 Neighboring gene epidermal growth factor receptor pathway substrate 8

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    General gene information

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables GDP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables GTPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in Ras protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in negative regulation of cell growth ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to hormone ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in fibrillar center ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    ras-related and estrogen-regulated growth inhibitor
    NP_001157684.1
    NP_001157686.1
    NP_871788.1
    XP_036021981.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001164212.1NP_001157684.1  ras-related and estrogen-regulated growth inhibitor isoform a

      See identical proteins and their annotated locations for NP_001157684.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1 and 2 each encode isoform a.
      Source sequence(s)
      AC122303, AC144767, AK133734
      Consensus CDS
      CCDS20663.1
      UniProtKB/Swiss-Prot
      Q8R367
      Related
      ENSMUSP00000113105.2, ENSMUST00000117919.8
      Conserved Domains (1) summary
      cd04146
      Location:8169
      RERG_RasL11_like; Ras-related and Estrogen-Regulated Growth inhibitor (RERG) and Ras-like 11 (RasL11)-like families
    2. NM_001164214.1NP_001157686.1  ras-related and estrogen-regulated growth inhibitor isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
      Source sequence(s)
      AC122303, AC144767, AK133734
      Consensus CDS
      CCDS51942.1
      UniProtKB/Swiss-Prot
      Q8R367
      UniProtKB/TrEMBL
      E9PUF8
      Related
      ENSMUSP00000113702.2, ENSMUST00000119610.4
      Conserved Domains (1) summary
      cl21455
      Location:8150
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    3. NM_181988.2NP_871788.1  ras-related and estrogen-regulated growth inhibitor isoform a

      See identical proteins and their annotated locations for NP_871788.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 each encode isoform a.
      Source sequence(s)
      AC122303, AC144767, AK133734
      Consensus CDS
      CCDS20663.1
      UniProtKB/Swiss-Prot
      Q8R367
      Related
      ENSMUSP00000032347.5, ENSMUST00000032347.11
      Conserved Domains (1) summary
      cd04146
      Location:8169
      RERG_RasL11_like; Ras-related and Estrogen-Regulated Growth inhibitor (RERG) and Ras-like 11 (RasL11)-like families

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      137031822..137147494 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036166088.1XP_036021981.1  ras-related and estrogen-regulated growth inhibitor isoform X1

      Conserved Domains (1) summary
      cl38936
      Location:1114
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
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