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    Ripor1 RHO family interacting cell polarization regulator 1 [ Mus musculus (house mouse) ]

    Gene ID: 75687, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Ripor1provided by MGI
    Official Full Name
    RHO family interacting cell polarization regulator 1provided by MGI
    Primary source
    MGI:MGI:1922937
    See related
    Ensembl:ENSMUSG00000038604 AllianceGenome:MGI:1922937
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Fam65a; 2310066E14Rik
    Summary
    Predicted to enable 14-3-3 protein binding activity. Predicted to be involved in several processes, including establishment of Golgi localization; negative regulation of Rho guanyl-nucleotide exchange factor activity; and negative regulation of Rho protein signal transduction. Located in cytoplasm. Is expressed in several structures, including adrenal gland; genitourinary system; hemolymphoid system; liver; and lung. Orthologous to human RIPOR1 (RHO family interacting cell polarization regulator 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in thymus adult (RPKM 26.2), lung adult (RPKM 19.8) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ripor1 in Genome Data Viewer
    Location:
    8 D3; 8 53.04 cM
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (106320588..106348851)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (105594087..105622219)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:108090885-108090994 Neighboring gene predicted gene, 38250 Neighboring gene agouti related neuropeptide Neighboring gene predicted gene 45855 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:108146466-108146676 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:108147057-108147307 Neighboring gene microRNA 1966 Neighboring gene predicted gene 5914 Neighboring gene CCCTC-binding factor Neighboring gene myosin light polypeptide 6-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Transcriptional regulation of agouti-related protein (Agrp) in transgenic mice. Kaelin CB, et al. Endocrinology, 2004 Dec. PMID 15345681
    2. Expression and subcellular distribution of novel glomerulus-associated proteins dendrin, ehd3, sh2d4a, plekhh2, and 2310066E14Rik. Patrakka J, et al. J Am Soc Nephrol, 2007 Mar. PMID 17251388
    3. Urogenital and caudal dysgenesis in adrenocortical dysplasia (acd) mice is caused by a splicing mutation in a novel telomeric regulator. Keegan CE, et al. Hum Mol Genet, 2005 Jan 1. PMID 15537664
    4. Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Feb 28. PMID 12693553
    5. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC100216

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 14-3-3 protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in Rho protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to chemokine ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to starvation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in establishment of Golgi localization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of Rho guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of Rho protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of intracellular protein transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to wounding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cell leading edge ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    rho family-interacting cell polarization regulator 1
    Names
    family with sequence similarity 65, member A
    protein FAM65A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081241.2 → NP_001074710.2  rho family-interacting cell polarization regulator 1

      See identical proteins and their annotated locations for NP_001074710.2

      Status: VALIDATED

      Source sequence(s)
      AK122573, BB852730, BC079880
      Consensus CDS
      CCDS52660.1
      UniProtKB/Swiss-Prot
      G5E8A2, Q68FE6, Q80T73, Q8K0T1, Q9D6R4
      Related
      ENSMUSP00000039966.9, ENSMUST00000043531.10
      Conserved Domains (4) summary
      pfam05109
      Location:444 → 749
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      sd00044
      Location:1097 → 1127
      HEAT; HEAT repeat [structural motif]
      pfam13646
      Location:1125 → 1189
      HEAT_2; HEAT repeats
      pfam15903
      Location:17 → 365
      PL48; Filopodia upregulated, FAM65

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      106320588..106348851
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011248531.4 → XP_011246833.2  rho family-interacting cell polarization regulator 1 isoform X1

      Conserved Domains (4) summary
      pfam05109
      Location:524 → 829
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      sd00044
      Location:1177 → 1207
      HEAT; HEAT repeat [structural motif]
      pfam13646
      Location:1205 → 1269
      HEAT_2; HEAT repeats
      pfam15903
      Location:97 → 445
      PL48; Filopodia upregulated, FAM65

    2. XM_011248532.4 → XP_011246834.2  rho family-interacting cell polarization regulator 1 isoform X2

      Conserved Domains (4) summary
      pfam05109
      Location:524 → 829
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      sd00044
      Location:1176 → 1206
      HEAT; HEAT repeat [structural motif]
      pfam13646
      Location:1204 → 1268
      HEAT_2; HEAT repeats
      pfam15903
      Location:97 → 445
      PL48; Filopodia upregulated, FAM65

    3. XM_036154352.1 → XP_036010245.1  rho family-interacting cell polarization regulator 1 isoform X6

      Conserved Domains (2) summary
      pfam05109
      Location:561 → 829
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam15903
      Location:97 → 445
      PL48; Filopodia upregulated, FAM65

    4. XM_036154351.1 → XP_036010244.1  rho family-interacting cell polarization regulator 1 isoform X4

      UniProtKB/Swiss-Prot
      G5E8A2, Q68FE6, Q80T73, Q8K0T1, Q9D6R4
      Conserved Domains (4) summary
      pfam05109
      Location:444 → 749
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      sd00044
      Location:1097 → 1127
      HEAT; HEAT repeat [structural motif]
      pfam13646
      Location:1125 → 1189
      HEAT_2; HEAT repeats
      pfam15903
      Location:17 → 365
      PL48; Filopodia upregulated, FAM65

    5. XM_006531461.5 → XP_006531524.1  rho family-interacting cell polarization regulator 1 isoform X3

      Conserved Domains (4) summary
      pfam05109
      Location:495 → 763
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      sd00044
      Location:1111 → 1141
      HEAT; HEAT repeat [structural motif]
      pfam15903
      Location:31 → 379
      PL48; Filopodia upregulated, FAM65
      pfam13646
      Location:1139 → 1203
      HEAT_2; HEAT repeats

    6. XM_006531463.2 → XP_006531526.1  rho family-interacting cell polarization regulator 1 isoform X5

      Conserved Domains (4) summary
      pfam05109
      Location:447 → 715
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      sd00044
      Location:1063 → 1093
      HEAT; HEAT repeat [structural motif]
      pfam15903
      Location:2 → 331
      PL48; Filopodia upregulated, FAM65
      pfam13646
      Location:1091 → 1155
      HEAT_2; HEAT repeats

    7. XM_030243830.1 → XP_030099690.1  rho family-interacting cell polarization regulator 1 isoform X7

      Conserved Domains (4) summary
      pfam05109
      Location:286 → 591
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      sd00044
      Location:939 → 969
      HEAT; HEAT repeat [structural motif]
      pfam15903
      Location:1 → 207
      PL48; Filopodia upregulated, FAM65
      pfam13646
      Location:967 → 1031
      HEAT_2; HEAT repeats
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q68FE6.2 GenPept UniProtKB/Swiss-Prot:Q68FE6

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