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    Galnt5 polypeptide N-acetylgalactosaminyltransferase 5 [ Mus musculus (house mouse) ]

    Gene ID: 241391, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Galnt5provided by MGI
    Official Full Name
    polypeptide N-acetylgalactosaminyltransferase 5provided by MGI
    Primary source
    MGI:MGI:2179403
    See related
    Ensembl:ENSMUSG00000026828 AllianceGenome:MGI:2179403
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4832424J23
    Summary
    Predicted to enable polypeptide N-acetylgalactosaminyltransferase activity. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in Golgi apparatus. Is expressed in several structures, including alimentary system; central nervous system; retina; and skeleton. Orthologous to human GALNT5 (polypeptide N-acetylgalactosaminyltransferase 5). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    human all
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    Genomic context

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    Location:
    2 C1.1; 2 32.93 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (57887832..57931039)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (57997850..58041027)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene ATP synthase membrane subunit DAPIT, mitochondrial pseudogene Neighboring gene predicted gene, 25388 Neighboring gene STARR-seq mESC enhancer starr_04536 Neighboring gene STARR-seq mESC enhancer starr_04537 Neighboring gene STARR-positive B cell enhancer mm9_chr2:57771733-57772033 Neighboring gene STARR-seq mESC enhancer starr_04538 Neighboring gene STARR-seq mESC enhancer starr_04539 Neighboring gene STARR-positive B cell enhancer mm9_chr2:57882224-57882524 Neighboring gene ermin, ERM-like protein Neighboring gene STARR-seq mESC enhancer starr_04540 Neighboring gene STARR-positive B cell enhancer ABC_E3374 Neighboring gene STARR-positive B cell enhancer ABC_E2036 Neighboring gene nudix (nucleoside diphosphate linked moiety X)-type motif 15 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E1589 Neighboring gene STARR-positive B cell enhancer ABC_E3375 Neighboring gene STARR-positive B cell enhancer ABC_E5917 Neighboring gene STARR-positive B cell enhancer ABC_E5918 Neighboring gene STARR-positive B cell enhancer ABC_E7817 Neighboring gene STARR-positive B cell enhancer ABC_E5919 Neighboring gene cytohesin 1 interacting protein Neighboring gene predicted gene 13546

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Diverse spatial expression patterns of UDP-GalNAc:polypeptide N-acetylgalactosaminyl-transferase family member mRNAs during mouse development. Kingsley PD, et al. Glycobiology, 2000 Dec. PMID 11159923
    2. Overexpression of Galnt3 in chondrocytes resulted in dwarfism due to the increase of mucin-type O-glycans and reduction of glycosaminoglycans. Yoshida CA, et al. J Biol Chem, 2014 Sep 19. PMID 25107907, Free PMC Article
    3. Galnt11 regulates kidney function by glycosylating the endocytosis receptor megalin to modulate ligand binding. Tian E, et al. Proc Natl Acad Sci U S A, 2019 Dec 10. PMID 31740596, Free PMC Article
    4. Loss of the disease-associated glycosyltransferase Galnt3 alters Muc10 glycosylation and the composition of the oral microbiome. Peluso G, et al. J Biol Chem, 2020 Jan 31. PMID 31882545, Free PMC Article
    5. Galnt1 is required for normal heart valve development and cardiac function. Tian E, et al. PLoS One, 2015. PMID 25615642, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables polypeptide N-acetylgalactosaminyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables polypeptide N-acetylgalactosaminyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein O-linked glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    polypeptide N-acetylgalactosaminyltransferase 5
    Names
    UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 5
    UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 5
    galNAc-T5
    polypeptide GalNAc transferase 5
    pp-GaNTase 5
    ppGaNTase-T5
    protein-UDP acetylgalactosaminyltransferase 5
    NP_766443.2
    XP_006498111.1
    XP_006498112.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_172855.3 → NP_766443.2  polypeptide N-acetylgalactosaminyltransferase 5

      See identical proteins and their annotated locations for NP_766443.2

      Status: VALIDATED

      Source sequence(s)
      BC116331, BC116332
      Consensus CDS
      CCDS38125.1
      UniProtKB/Swiss-Prot
      A2AS75, Q8C102
      UniProtKB/TrEMBL
      Q14B51
      Related
      ENSMUSP00000108235.2, ENSMUST00000112616.8
      Conserved Domains (2) summary
      cd02510
      Location:489 → 790
      pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
      smart00458
      Location:805 → 925
      RICIN; Ricin-type beta-trefoil

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      57887832..57931039
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006498049.3 → XP_006498112.1  polypeptide N-acetylgalactosaminyltransferase 5 isoform X1

      See identical proteins and their annotated locations for XP_006498112.1

      UniProtKB/Swiss-Prot
      A2AS75, Q8C102
      UniProtKB/TrEMBL
      Q14B51
      Conserved Domains (2) summary
      cd02510
      Location:489 → 790
      pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
      smart00458
      Location:805 → 925
      RICIN; Ricin-type beta-trefoil

    2. XM_006498048.5 → XP_006498111.1  polypeptide N-acetylgalactosaminyltransferase 5 isoform X1

      See identical proteins and their annotated locations for XP_006498111.1

      UniProtKB/Swiss-Prot
      A2AS75, Q8C102
      UniProtKB/TrEMBL
      Q14B51
      Conserved Domains (2) summary
      cd02510
      Location:489 → 790
      pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
      smart00458
      Location:805 → 925
      RICIN; Ricin-type beta-trefoil
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8C102.2 GenPept UniProtKB/Swiss-Prot:Q8C102

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