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    Hacl1 2-hydroxyacyl-CoA lyase 1 [ Mus musculus (house mouse) ]

    Gene ID: 56794, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Hacl1provided by MGI
    Official Full Name
    2-hydroxyacyl-CoA lyase 1provided by MGI
    Primary source
    MGI:MGI:1929657
    See related
    Ensembl:ENSMUSG00000021884 AllianceGenome:MGI:1929657
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Hpcl; Phyh2; 1600020H07Rik
    Summary
    Enables carbon-carbon lyase activity. Involved in fatty acid alpha-oxidation. Acts upstream of or within lipid metabolic process. Predicted to be located in nucleoplasm. Predicted to be active in peroxisome. Is expressed in several structures, including adipose tissue; alimentary system; eye; genitourinary system; and nervous system. Orthologous to human HACL1 (2-hydroxyacyl-CoA lyase 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in liver adult (RPKM 112.3), liver E18 (RPKM 83.8) and 2 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    14 B; 14 19.23 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (31329183..31364201, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (31607226..31640965, complement)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:32345029-32345265 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:32369012-32369287 Neighboring gene collagen like tail subunit of asymmetric acetylcholinesterase Neighboring gene STARR-seq mESC enhancer starr_36317 Neighboring gene predicted gene, 57482 Neighboring gene STARR-seq mESC enhancer starr_36319 Neighboring gene STARR-positive B cell enhancer ABC_E11568 Neighboring gene STARR-positive B cell enhancer ABC_E7304 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:32483369-32483556 Neighboring gene biotinidase Neighboring gene predicted gene, 53840 Neighboring gene ankyrin repeat domain 28 Neighboring gene STARR-positive B cell enhancer ABC_E4102 Neighboring gene STARR-seq mESC enhancer starr_36323 Neighboring gene STARR-seq mESC enhancer starr_36326 Neighboring gene RIKEN cDNA D830044D21 gene Neighboring gene predicted gene, 36164

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Tissue Proteome of 2-Hydroxyacyl-CoA Lyase Deficient Mice Reveals Peroxisome Proliferation and Activation of ω-Oxidation. Khalil Y, et al. Int J Mol Sci, 2022 Jan 17. PMID 35055171, Free PMC Article
    2. Peroxisomal 2-Hydroxyacyl-CoA Lyase Is Involved in Endogenous Biosynthesis of Heptadecanoic Acid. Jenkins B, et al. Molecules, 2017 Oct 13. PMID 29027957, Free PMC Article
    3. Phytol-induced pathology in 2-hydroxyacyl-CoA lyase (HACL1) deficient mice. Evidence for a second non-HACL1-related lyase. Mezzar S, et al. Biochim Biophys Acta Mol Cell Biol Lipids, 2017 Sep. PMID 28629946
    4. Breakdown of 2-hydroxylated straight chain fatty acids via peroxisomal 2-hydroxyphytanoyl-CoA lyase: a revised pathway for the alpha-oxidation of straight chain fatty acids. Foulon V, et al. J Biol Chem, 2005 Mar 18. PMID 15644336
    5. RP-HPLC-fluorescence analysis of aliphatic aldehydes: application to aldehyde-generating enzymes HACL1 and SGPL1. Mezzar S, et al. J Lipid Res, 2014 Mar. PMID 24323699, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Tissue Proteome of 2-Hydroxyacyl-CoA Lyase Deficient Mice Reveals Peroxisome Proliferation and Activation of omega-Oxidation.
      Title: Tissue Proteome of 2-Hydroxyacyl-CoA Lyase Deficient Mice Reveals Peroxisome Proliferation and Activation of ω-Oxidation.
    2. Hacl1 plays a significant role in the liver and plasma levels of C17:0, providing evidence it can be endogenously biosynthesized via alpha-oxidation
      Title: Peroxisomal 2-Hydroxyacyl-CoA Lyase Is Involved in Endogenous Biosynthesis of Heptadecanoic Acid.
    3. 2-hydroxyphytanoyl-CoA lyase has a role in the breakdown of long chain 2-hydroxyfatty acids
      Title: Breakdown of 2-hydroxylated straight chain fatty acids via peroxisomal 2-hydroxyphytanoyl-CoA lyase: a revised pathway for the alpha-oxidation of straight chain fatty acids.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 2-hydroxyacyl-CoA lyase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables carbon-carbon lyase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables carbon-carbon lyase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables lyase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables magnesium ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables thiamine pyrophosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables thiamine pyrophosphate binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in fatty acid alpha-oxidation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fatty acid alpha-oxidation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in fatty acid alpha-oxidation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in fatty acid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within lipid metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in methyl-branched fatty acid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in phytanic acid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein targeting to peroxisome ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in peroxisome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in peroxisome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in peroxisome TAS
    Traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    2-hydroxyacyl-CoA lyase 1
    Names
    2-HPCL
    2-hydroxyphytanoyl-CoA lyase
    phytanoyl-CoA 2-hydroxylase 2
    NP_064359.2
    XP_036014660.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019975.3 → NP_064359.2  2-hydroxyacyl-CoA lyase 1

      See identical proteins and their annotated locations for NP_064359.2

      Status: VALIDATED

      Source sequence(s)
      AK041686, BY340097
      Consensus CDS
      CCDS26915.1
      UniProtKB/Swiss-Prot
      Q543K1, Q9DAV1, Q9QXE0
      UniProtKB/TrEMBL
      D3YZ54
      Related
      ENSMUSP00000022437.9, ENSMUST00000022437.16
      Conserved Domains (4) summary
      cd07035
      Location:22 → 175
      TPP_PYR_POX_like; Pyrimidine (PYR) binding domain of POX and related proteins
      PRK09259
      Location:19 → 564
      PRK09259; putative oxalyl-CoA decarboxylase; Validated
      cd02004
      Location:380 → 563
      TPP_BZL_OCoD_HPCL; Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL ...
      pfam00205
      Location:208 → 335
      TPP_enzyme_M; Thiamine pyrophosphate enzyme, central domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      31329183..31364201 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036158767.1 → XP_036014660.1  2-hydroxyacyl-CoA lyase 1 isoform X1

      UniProtKB/TrEMBL
      D3YZ54
      Conserved Domains (1) summary
      PRK09259
      Location:19 → 555
      PRK09259; putative oxalyl-CoA decarboxylase; Validated
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9QXE0.2 GenPept UniProtKB/Swiss-Prot:Q9QXE0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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