Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Adam8 a disintegrin and metallopeptidase domain 8 [ Mus musculus (house mouse) ]

    Gene ID: 11501, updated on 8-Jul-2021

    Summary

    Official Symbol
    Adam8provided by MGI
    Official Full Name
    a disintegrin and metallopeptidase domain 8provided by MGI
    Primary source
    MGI:MGI:107825
    See related
    Ensembl:ENSMUSG00000025473
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MS; MS2; CD156; ADAM 8; CD156a; E430039A18Rik
    Summary
    This gene encodes a member of the Adam family of proteins that contain the disintegrin and metalloprotease domains. The encoded protein is localized to the cell surface, where it is involved in the remodeling of extracellular matrix and cell migration. Mice lacking the encoded protein display persistent inflammation upon treatment with allergens. Alternative splicing of this gene results in multiple variants. [provided by RefSeq, Mar 2015]
    Expression
    Broad expression in ovary adult (RPKM 21.0), thymus adult (RPKM 6.6) and 19 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Adam8 in Genome Data Viewer
    Location:
    7; 7 F4
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (139558845..139573016, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (139978932..139995207, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (147164840..147178387, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene 16201 Neighboring gene microRNA 202 Neighboring gene sperm flagellar 1 like Neighboring gene microRNA 7062 Neighboring gene tubulin, gamma complex associated protein 2 Neighboring gene zinc finger protein 511 Neighboring gene msh homeobox 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium ion binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables cell adhesion molecule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables cell adhesion molecule binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables cell adhesion molecule binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables integrin binding TAS
    Traceable Author Statement
    more info
    PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables metalloendopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables metallopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables metallopeptidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables metallopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables zinc ion binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in angiogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in blood vessel endothelial cell migration NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in cell morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within cell-cell adhesion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cell-matrix adhesion TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in cellular response to hypoxia ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in inflammatory response IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in inflammatory response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in leukocyte migration involved in inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in lymphocyte chemotaxis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in membrane fusion TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in negative regulation of neuron apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of thymocyte aggregation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in osteoclast fusion TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of MAP kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of NF-kappaB transcription factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of T cell differentiation in thymus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of T cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of acute inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of bone resorption IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of bone resorption IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of cell adhesion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of cellular extravasation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in positive regulation of cellular extravasation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of eosinophil migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of fibronectin-dependent thymocyte migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of inflammatory response IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of innate immune response IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of membrane protein ectodomain proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in positive regulation of membrane protein ectodomain proteolysis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of membrane protein ectodomain proteolysis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of neutrophil extravasation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein kinase B signaling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of thymocyte apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of tumor necrosis factor (ligand) superfamily member 11 production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of cell-cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in regulation of cell-cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of osteoclast differentiation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in tissue morphogenesis TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of alpha9-beta1 integrin-ADAM8 complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in dense core granule membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in integral component of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in phagolysosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in podosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in podosome TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in specific granule ISO
    Inferred from Sequence Orthology
    more info
     
    located_in tertiary granule ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    disintegrin and metalloproteinase domain-containing protein 8
    Names
    a disintegrin and metalloprotease domain 8
    cell surface antigen MS2
    macrophage cysteine-rich glycoprotein
    NP_001277995.1
    NP_031429.1
    XP_006536214.1
    XP_017177421.1
    XP_017177422.1
    XP_017177423.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001291066.2NP_001277995.1  disintegrin and metalloproteinase domain-containing protein 8 isoform 2 precursor

      See identical proteins and their annotated locations for NP_001277995.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice acceptor site compared to variant 1. It encodes a protein (isoform 2) that is slightly shorter than isoform 1.
      Source sequence(s)
      AC107822, AK152675, BE634944
      Consensus CDS
      CCDS72064.1
      UniProtKB/TrEMBL
      Q3U7G2
      Related
      ENSMUSP00000026546.10, ENSMUST00000026546.16
      Conserved Domains (5) summary
      smart00050
      Location:411485
      DISIN; Homologues of snake disintegrins
      smart00608
      Location:487606
      ACR; ADAM Cysteine-Rich Domain
      cd04269
      Location:195392
      ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
      pfam01421
      Location:195394
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:49148
      Pep_M12B_propep; Reprolysin family propeptide
    2. NM_007403.3NP_031429.1  disintegrin and metalloproteinase domain-containing protein 8 isoform 1 precursor

      See identical proteins and their annotated locations for NP_031429.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer protein isoform (1).
      Source sequence(s)
      AC107822, AK155912, BE634944
      Consensus CDS
      CCDS21959.1
      UniProtKB/Swiss-Prot
      Q05910
      UniProtKB/TrEMBL
      Q3U1J7
      Related
      ENSMUSP00000101684.3, ENSMUST00000106069.9
      Conserved Domains (5) summary
      smart00050
      Location:412486
      DISIN; Homologues of snake disintegrins
      smart00608
      Location:488607
      ACR; ADAM Cysteine-Rich Domain
      cd04269
      Location:196393
      ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
      pfam01421
      Location:196395
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:50149
      Pep_M12B_propep; Reprolysin family propeptide

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      139558845..139573016 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017321933.3XP_017177422.1  disintegrin and metalloproteinase domain-containing protein 8 isoform X2

      Conserved Domains (6) summary
      smart00050
      Location:411485
      DISIN; Homologues of snake disintegrins
      smart00608
      Location:487606
      ACR; ADAM Cysteine-Rich Domain
      PHA03247
      Location:637856
      PHA03247; large tegument protein UL36; Provisional
      pfam01421
      Location:195394
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:27151
      Pep_M12B_propep; Reprolysin family propeptide
      pfam05104
      Location:770855
      Rib_recp_KP_reg; Ribosome receptor lysine/proline rich region
    2. XM_006536151.4XP_006536214.1  disintegrin and metalloproteinase domain-containing protein 8 isoform X3

      Conserved Domains (5) summary
      smart00050
      Location:412486
      DISIN; Homologues of snake disintegrins
      smart00608
      Location:488607
      ACR; ADAM Cysteine-Rich Domain
      pfam01421
      Location:196395
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:28152
      Pep_M12B_propep; Reprolysin family propeptide
      pfam05104
      Location:766851
      Rib_recp_KP_reg; Ribosome receptor lysine/proline rich region
    3. XM_017321932.3XP_017177421.1  disintegrin and metalloproteinase domain-containing protein 8 isoform X1

      Conserved Domains (6) summary
      smart00050
      Location:412486
      DISIN; Homologues of snake disintegrins
      smart00608
      Location:488607
      ACR; ADAM Cysteine-Rich Domain
      PHA03247
      Location:638857
      PHA03247; large tegument protein UL36; Provisional
      pfam01421
      Location:196395
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:28152
      Pep_M12B_propep; Reprolysin family propeptide
      pfam05104
      Location:771856
      Rib_recp_KP_reg; Ribosome receptor lysine/proline rich region
    4. XM_017321934.3XP_017177423.1  disintegrin and metalloproteinase domain-containing protein 8 isoform X4

      Related
      ENSMUSP00000117858.2, ENSMUST00000148670.8
      Conserved Domains (4) summary
      smart00050
      Location:412486
      DISIN; Homologues of snake disintegrins
      smart00608
      Location:488607
      ACR; ADAM Cysteine-Rich Domain
      pfam01421
      Location:196395
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:28152
      Pep_M12B_propep; Reprolysin family propeptide
    Support Center