Tlcd2 TLC domain containing 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tlcd2provided by MGI
Official Full Name: TLC domain containing 2provided by MGI
Primary source: MGI:MGI:1917141
See related: Ensembl:ENSMUSG00000038217 AllianceGenome:MGI:1917141
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Predicted to be involved in several processes, including membrane assembly; phospholipid homeostasis; and regulation of membrane lipid distribution. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including central nervous system and retina. Orthologous to human TLCD2 (TLC domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in liver adult (RPKM 69.7), duodenum adult (RPKM 20.6) and 11 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 B5; 11 45.91 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (75358771..75361725)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (75468024..75470899)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in membrane assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in membrane assembly	ISO Inferred from Sequence Orthology more info
involved_in phospholipid homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in phospholipid homeostasis	ISO Inferred from Sequence Orthology more info
involved_in plasma membrane organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in plasma membrane organization	ISO Inferred from Sequence Orthology more info
involved_in regulation of membrane lipid distribution	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of membrane lipid distribution	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: TLC domain-containing protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001291156.1 → NP_001278085.1 TLC domain-containing protein 2 isoform 2

See identical proteins and their annotated locations for NP_001278085.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an exon in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus, compared to isoform 1.

Source sequence(s)

AI549721, AK008522, CO044816, CV562896

Consensus CDS

CCDS70238.1

UniProtKB/Swiss-Prot

Q8VC26

Related

ENSMUSP00000104074.2, ENSMUST00000108435.2

Conserved Domains (1) summary

cl02759
Location:33 → 143

TRAM_LAG1_CLN8; TLC domain
NM_027249.3 → NP_081525.1 TLC domain-containing protein 2 isoform 1

See identical proteins and their annotated locations for NP_081525.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AI549721, AL591496, CO044816, CV562896

Consensus CDS

CCDS48850.1

UniProtKB/Swiss-Prot

Q8VC26, Q9D837

Related

ENSMUSP00000042958.8, ENSMUST00000043598.14

Conserved Domains (1) summary

smart00724
Location:33 → 225

TLC; TRAM, LAG1 and CLN8 homology domains

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

75358771..75361725

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011249099.2 → XP_011247401.1 TLC domain-containing protein 2 isoform X1

Conserved Domains (1) summary

cl02759
Location:33 → 143

TRAM_LAG1_CLN8; TLC domain