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    Btbd7 BTB domain containing 7 [ Mus musculus (house mouse) ]

    Gene ID: 238386, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Btbd7provided by MGI
    Official Full Name
    BTB domain containing 7provided by MGI
    Primary source
    MGI:MGI:1917858
    See related
    Ensembl:ENSMUSG00000041702 AllianceGenome:MGI:1917858
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    FUP1; mKIAA1525; 8030448M07; 5730507E09Rik; E130118E17Rik
    Summary
    Acts upstream of or within regulation of branching involved in salivary gland morphogenesis. Located in nucleus. Is expressed in early conceptus and genitourinary system. Orthologous to human BTBD7 (BTB domain containing 7). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in limb E14.5 (RPKM 6.7), bladder adult (RPKM 6.5) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    12 E; 12 52.25 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (102747056..102844733, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (102780797..102878471, complement)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_33118 Neighboring gene predicted gene 20604 Neighboring gene STARR-seq mESC enhancer starr_33119 Neighboring gene GON7 subunit of KEOPS complex Neighboring gene ubiquitin protein ligase E3 component n-recognin 7 (putative) Neighboring gene cytochrome c oxidase subunit 7C, mitochondrial pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E8503 Neighboring gene ribosomal protein S2 pseudogene Neighboring gene cytochrome c oxidase subunit 8C Neighboring gene unc-79 homolog Neighboring gene STARR-seq mESC enhancer starr_33121

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. FUP1, a gene associated with hepatocellular carcinoma, stimulates NIH3T3 cell proliferation and tumor formation in nude mice. Pan W, et al. Biochem Biophys Res Commun, 2001 Sep 7. PMID 11527404
    2. Involvement of the T-box transcription factor Brachyury in early-stage embryonic mouse salivary gland. Hayashi K, et al. Biochem Biophys Res Commun, 2016 Sep 2. PMID 27369076
    3. Btbd7 regulates epithelial cell dynamics and branching morphogenesis. Onodera T, et al. Science, 2010 Jul 30. PMID 20671187, Free PMC Article
    4. Adamts18 Deficiency Causes Spontaneous SMG Fibrogenesis in Adult Mice. Yang N, et al. J Dent Res, 2022 Feb. PMID 34323105
    5. Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Feb 28. PMID 12693553

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC49574

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in morphogenesis of a branching epithelium IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of branching involved in salivary gland morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of branching involved in salivary gland morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    BTB/POZ domain-containing protein 7
    Names
    BTB (POZ) domain containing 7
    function-unkown protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001377026.1 → NP_001363955.1  BTB/POZ domain-containing protein 7

      Status: VALIDATED

      Source sequence(s)
      AC122367, AC132315
      UniProtKB/Swiss-Prot
      Q80TC3, Q8BZY9, Q8CFE5
      Related
      ENSMUSP00000046951.7, ENSMUST00000045652.8
      Conserved Domains (3) summary
      cd18283
      Location:140 → 231
      BTB1_POZ_BTBD7; first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 7 (BTBD7)
      cd18284
      Location:245 → 392
      BTB2_POZ_BTBD7; second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 7 (BTBD7)
      cd18489
      Location:397 → 494
      BACK_BTBD7; BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 7 (BTBD7)

    2. NM_172806.3 → NP_766394.2  BTB/POZ domain-containing protein 7

      See identical proteins and their annotated locations for NP_766394.2

      Status: VALIDATED

      Source sequence(s)
      AC122367, AC132315
      Consensus CDS
      CCDS26125.1
      UniProtKB/Swiss-Prot
      Q80TC3, Q8BZY9, Q8CFE5
      Related
      ENSMUSP00000152426.2, ENSMUST00000223554.2
      Conserved Domains (3) summary
      cd18283
      Location:140 → 231
      BTB1_POZ_BTBD7; first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 7 (BTBD7)
      cd18284
      Location:245 → 392
      BTB2_POZ_BTBD7; second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 7 (BTBD7)
      cd18489
      Location:397 → 494
      BACK_BTBD7; BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 7 (BTBD7)

    RNA

    1. NR_165048.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC122367, AC132315

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      102747056..102844733 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036157405.1 → XP_036013298.1  BTB/POZ domain-containing protein 7 isoform X1

    2. XM_036157406.1 → XP_036013299.1  BTB/POZ domain-containing protein 7 isoform X2

      Conserved Domains (2) summary
      cd18283
      Location:140 → 231
      BTB1_POZ_BTBD7; first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 7 (BTBD7)
      cd18284
      Location:245 → 388
      BTB2_POZ_BTBD7; second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 7 (BTBD7)

    RNA

    1. XR_004937501.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8CFE5.1 GenPept UniProtKB/Swiss-Prot:Q8CFE5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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