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    Galnt14 polypeptide N-acetylgalactosaminyltransferase 14 [ Mus musculus (house mouse) ]

    Gene ID: 71685, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Galnt14provided by MGI
    Official Full Name
    polypeptide N-acetylgalactosaminyltransferase 14provided by MGI
    Primary source
    MGI:MGI:1918935
    See related
    Ensembl:ENSMUSG00000024064 AllianceGenome:MGI:1918935
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    0610033M06Rik
    Summary
    Predicted to enable carbohydrate binding activity; metal ion binding activity; and polypeptide N-acetylgalactosaminyltransferase activity. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in Golgi apparatus. Is expressed in several structures, including nervous system and sensory organ. Orthologous to human GALNT14 (polypeptide N-acetylgalactosaminyltransferase 14). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in kidney adult (RPKM 4.0), CNS E18 (RPKM 1.7) and 10 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    17 44.88 cM; 17 E2
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (73800202..74019138, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (73493207..73712138, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA E330032C10 gene Neighboring gene STARR-positive B cell enhancer ABC_E10970 Neighboring gene STARR-positive B cell enhancer ABC_E7556 Neighboring gene calpain 13 Neighboring gene STARR-seq mESC enhancer starr_43202 Neighboring gene predicted gene, 46602 Neighboring gene STARR-seq mESC enhancer starr_43203 Neighboring gene predicted gene, 52320 Neighboring gene EH-domain containing 3 Neighboring gene predicted gene, 53977

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Overexpression of Galnt3 in chondrocytes resulted in dwarfism due to the increase of mucin-type O-glycans and reduction of glycosaminoglycans. Yoshida CA, et al. J Biol Chem, 2014 Sep 19. PMID 25107907, Free PMC Article
    2. Galnt11 regulates kidney function by glycosylating the endocytosis receptor megalin to modulate ligand binding. Tian E, et al. Proc Natl Acad Sci U S A, 2019 Dec 10. PMID 31740596, Free PMC Article
    3. Genetic Labeling of Nuclei-Specific Thalamocortical Neurons Reveals Putative Sensory-Modality Specific Genes. Gezelius H, et al. Cereb Cortex, 2017 Nov 1. PMID 27655933, Free PMC Article
    4. Loss of the disease-associated glycosyltransferase Galnt3 alters Muc10 glycosylation and the composition of the oral microbiome. Peluso G, et al. J Biol Chem, 2020 Jan 31. PMID 31882545, Free PMC Article
    5. Galnt1 is required for normal heart valve development and cardiac function. Tian E, et al. PLoS One, 2015. PMID 25615642, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1)  1 citation
    • Endonuclease-mediated (2) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables polypeptide N-acetylgalactosaminyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in protein O-linked glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    polypeptide N-acetylgalactosaminyltransferase 14
    Names
    UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 14
    UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 14
    galNAc-T14
    polypeptide GalNAc transferase 14
    pp-GaNTase 14
    protein-UDP acetylgalactosaminyltransferase 14
    NP_082140.2
    XP_006525003.1
    XP_006525004.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_027864.2 → NP_082140.2  polypeptide N-acetylgalactosaminyltransferase 14

      See identical proteins and their annotated locations for NP_082140.2

      Status: VALIDATED

      Source sequence(s)
      AK078292, BC117800, BY733448
      Consensus CDS
      CCDS28965.1
      UniProtKB/Swiss-Prot
      Q60GT2, Q8BTI6, Q8BVG5, Q9DCJ2
      UniProtKB/TrEMBL
      Q08EC9
      Related
      ENSMUSP00000024858.6, ENSMUST00000024858.12
      Conserved Domains (4) summary
      cd02510
      Location:114 → 408
      pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
      cd00161
      Location:422 → 547
      RICIN; Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific ...
      pfam00652
      Location:422 → 545
      Ricin_B_lectin; Ricin-type beta-trefoil lectin domain
      pfam13641
      Location:111 → 337
      Glyco_tranf_2_3; Glycosyltransferase like family 2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      73800202..74019138 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006524941.4 → XP_006525004.1  polypeptide N-acetylgalactosaminyltransferase 14 isoform X2

      Conserved Domains (2) summary
      pfam00652
      Location:153 → 276
      Ricin_B_lectin; Ricin-type beta-trefoil lectin domain
      cl11394
      Location:42 → 139
      Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold

    2. XM_006524940.4 → XP_006525003.1  polypeptide N-acetylgalactosaminyltransferase 14 isoform X1

      Conserved Domains (1) summary
      cl11394
      Location:114 → 310
      Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold

    RNA

    1. XR_003952183.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BVG5.2 GenPept UniProtKB/Swiss-Prot:Q8BVG5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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