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    Fjx1 four jointed box 1 [ Mus musculus (house mouse) ]

    Gene ID: 14221, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Fjx1provided by MGI
    Official Full Name
    four jointed box 1provided by MGI
    Primary source
    MGI:MGI:1341907
    See related
    Ensembl:ENSMUSG00000075012 AllianceGenome:MGI:1341907
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Acts upstream of or within retina layer formation. Located in extracellular space. Is expressed in several structures, including alimentary system; central nervous system; embryo ectoderm; eye; and genitourinary system. Orthologous to human FJX1 (four-jointed box kinase 1). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    human all
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    Genomic context

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    See Fjx1 in Genome Data Viewer
    Location:
    2 E2; 2 54.13 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (102279711..102282137, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (102449366..102451792, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene tripartite motif-containing 44 Neighboring gene predicted gene, 52521 Neighboring gene STARR-positive B cell enhancer ABC_E3386 Neighboring gene STARR-seq mESC enhancer starr_05251 Neighboring gene STARR-seq mESC enhancer starr_05252 Neighboring gene predicted gene, 39890 Neighboring gene STARR-seq mESC enhancer starr_05255 Neighboring gene STARR-seq mESC enhancer starr_05256 Neighboring gene peptidase domain containing associated with muscle regeneration 1 Neighboring gene STARR-seq mESC enhancer starr_05257 Neighboring gene STARR-seq mESC enhancer starr_05258 Neighboring gene predicted gene, 57687 Neighboring gene solute carrier family 1 (glial high affinity glutamate transporter), member 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Four jointed box 1 promotes angiogenesis and is associated with poor patient survival in colorectal carcinoma. Al-Greene NT, et al. PLoS One, 2013. PMID 23922772, Free PMC Article
    2. The rodent Four-jointed ortholog Fjx1 regulates dendrite extension. Probst B, et al. Dev Biol, 2007 Dec 1. PMID 18028897
    3. [FJX1 overexpression is associated with poor prognosis and promotes gastric cancer proliferation via the PI3K/AKT signaling pathway]. Zhang H, et al. Nan Fang Yi Ke Da Xue Xue Bao, 2023 Jun 20. PMID 37439170, Free PMC Article
    4. Four-jointed knock-out delays renal failure in an ADPKD model with kidney injury. Formica C, et al. J Pathol, 2019 Sep. PMID 31038742, Free PMC Article
    5. Fjx1, the murine homologue of the Drosophila four-jointed gene, codes for a putative secreted protein expressed in restricted domains of the developing and adult brain. Ashery-Padan R, et al. Mech Dev, 1999 Feb. PMID 10072791

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. [FJX1 overexpression is associated with poor prognosis and promotes gastric cancer proliferation via the PI3K/AKT signaling pathway].
      Title: [FJX1 overexpression is associated with poor prognosis and promotes gastric cancer proliferation via the PI3K/AKT signaling pathway].
    2. Fjx1 disruption protects the cystic kidneys against kidney failure by reducing inflammation and fibrosis.
      Title: Four-jointed knock-out delays renal failure in an ADPKD model with kidney injury.
    3. These results identify Fjx1 as a new inhibitory factor that regulates dendrite extension.
      Title: The rodent Four-jointed ortholog Fjx1 regulates dendrite extension.
    4. fjx1 is expressed in the peripheral nervous system, epithelial cells of multiple organs, and during limb development
      Title: Fjx1: a notch-inducible secreted ligand with specific binding sites in developing mouse embryos and adult brain.
    5. data are compatible with conservation and sub-functionalization of dachsous 1, Fj, and Fat signaling in higher vertebrates
      Title: Expression of mouse dchs1, fjx1, and fat-j suggests conservation of the planar cell polarity pathway identified in Drosophila.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (3)  1 citation
    • Endonuclease-mediated (3) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in cell-cell signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within retina layer formation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    four-jointed box protein 1
    Names
    four-jointed protein homolog
    four-jointed protein x1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010218.2 → NP_034348.2  four-jointed box protein 1 precursor

      See identical proteins and their annotated locations for NP_034348.2

      Status: PROVISIONAL

      Source sequence(s)
      BC051990
      Consensus CDS
      CCDS16467.1
      UniProtKB/Swiss-Prot
      Q8BQB4, Q9Z1M1
      Related
      ENSMUSP00000097270.4, ENSMUST00000099678.5
      Conserved Domains (1) summary
      cd10468
      Location:146 → 430
      Four-jointed-like_C; C-terminal kinase domain of Drosophila Four-jointed (Fj), mouse Fjx1, and related proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      102279711..102282137 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BQB4.1 GenPept UniProtKB/Swiss-Prot:Q8BQB4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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