Ccnt1 cyclin T1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ccnt1provided by MGI
Official Full Name: cyclin T1provided by MGI
Primary source: MGI:MGI:1328363
See related: Ensembl:ENSMUSG00000011960 AllianceGenome:MGI:1328363
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CycT1; 2810478G24Rik
Summary: Enables chromatin binding activity; nucleic acid binding activity; and protein kinase binding activity. Predicted to be involved in negative regulation of mRNA polyadenylation; positive regulation of DNA-templated transcription, elongation; and positive regulation of transcription by RNA polymerase II. Predicted to act upstream of or within protein phosphorylation. Located in nucleus. Is expressed in several structures, including central nervous system; early embryo; gonad; hemolymphoid system gland; and limb. Orthologous to human CCNT1 (cyclin T1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in thymus adult (RPKM 6.7), CNS E11.5 (RPKM 5.3) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15 F1; 15 54.54 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (98436570..98468340, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (98538690..98567736, complement)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CDK9-cyclin T1 and CDK9-cyclin T2/K complexes have opposing roles in CHOP expression and chronic kidney disease -induced vascular calcification.
Title: The CDK9-cyclin T1 complex mediates saturated fatty acid-induced vascular calcification by inducing expression of the transcription factor CHOP.
Data show that the minimal 90-amino acid AF9 fragment in MLL-AF9 retains an ability to form higher order complexes with AF4*P-TEFb and with DOT1.
Title: Function of leukemogenic mixed lineage leukemia 1 (MLL) fusion proteins through distinct partner protein complexes.
Data show that the CDK9 and cyclin T1 subunits of P-TEFb are present in mouse oocytes and preimplantation embryos, and that CDK9 is essential for embryonic genome activation in the mouse.
Title: The CDK9/cyclin T1 subunits of P-TEFb in mouse oocytes and preimplantation embryos: a possible role in embryonic genome activation.
Cyclin T1 oncogenic function and suggest a role for this protein in controlling cell cycle probably via Rb/E2F1 pathway.
Title: Cyclin T1 overexpression induces malignant transformation and tumor growth.
the reduced level of CLP-1 introduced in the background of elevated levels of cyclin T1 elevates derepression of P-TEFb activity and emphasizes the importance of the role of CLP-1 in the mechanism governing compensatory hypertrophy in cardiomyocytes.
Title: Positive transcription elongation factor b activity in compensatory myocardial hypertrophy is regulated by cardiac lineage protein-1.
These data link the P-TEFb equilibrium to the intracellular transcriptional demand and proliferative/differentiated states of cells.
Title: Modulation of a P-TEFb functional equilibrium for the global control of cell growth and differentiation.
knockdown of CycT1 from P-TEFb abolishes both of the different chromatin loops regulating CD4 expression
Title: Differential chromatin looping regulates CD4 expression in immature thymocytes.
P-TEFb is a key mediator of Myc activated transcription by stimulating elongation
Title: Myc recruits P-TEFb to mediate the final step in the transcriptional activation of the cad promoter.
CDK9 has the intrinsic property to shuttle between nucleus and cytoplasm, and enhanced expression of cyclin T1 promotes its nuclear localization.
Title: CDK9 has the intrinsic property to shuttle between nucleus and cytoplasm, and enhanced expression of cyclin T1 promotes its nuclear localization.
location of the cyclin T1 gene regulatory elements is male germ cell-specific
Title: Unexpected high testis-specific transcriptional activity of the cyclin T1 promoter in transgenic mice.

Submit: New GeneRIF Correction See all GeneRIFs (12)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D9Mit34.1 (e-PCR), detects polymorphism
- UniSTS:131903

RH135890 (e-PCR)
- UniSTS:209888

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 7SK snRNA binding	ISO Inferred from Sequence Orthology more info
enables DNA binding	ISO Inferred from Sequence Orthology more info	PubMed
enables DNA-binding transcription factor binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase binding	ISO Inferred from Sequence Orthology more info
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables cyclin-dependent protein serine/threonine kinase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables cyclin-dependent protein serine/threonine kinase activator activity	ISO Inferred from Sequence Orthology more info
enables cyclin-dependent protein serine/threonine kinase regulator activity	IEA Inferred from Electronic Annotation more info
enables molecular condensate scaffold activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IDA Inferred from Direct Assay more info	PubMed
enables snRNA binding	IDA Inferred from Direct Assay more info	PubMed
enables transcription cis-regulatory region binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell cycle	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell division	IEA Inferred from Electronic Annotation more info
involved_in positive regulation by host of viral transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription, elongation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription elongation by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein phosphorylation	ISO Inferred from Sequence Orthology more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of P-TEFb complex	ISO Inferred from Sequence Orthology more info
part_of cyclin/CDK positive transcription elongation factor complex	IBA Inferred from Biological aspect of Ancestor more info
part_of cyclin/CDK positive transcription elongation factor complex	ISO Inferred from Sequence Orthology more info
part_of cyclin/CDK positive transcription elongation factor complex	TAS Traceable Author Statement more info	PubMed
located_in cytosol	ISO Inferred from Sequence Orthology more info
NOT located_in nucleolus	ISO Inferred from Sequence Orthology more info	PubMed
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: cyclin-T1

Names: cyclin-T

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001368702.1 → NP_001355631.1 cyclin-T1 isoform 2

Status: VALIDATED

Source sequence(s)

AC138221

Conserved Domains (1) summary

cd00043
Location:38 → 109

CYCLIN; Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...
NM_009833.2 → NP_033963.1 cyclin-T1 isoform 1

See identical proteins and their annotated locations for NP_033963.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).

Source sequence(s)

AC138221

Consensus CDS

CCDS27797.1

UniProtKB/Swiss-Prot

Q3V0G4, Q9QWV9, Q9Z0U7

Related

ENSMUSP00000012104.7, ENSMUST00000012104.7

Conserved Domains (1) summary

pfam00134
Location:13 → 149

Cyclin_N; Cyclin, N-terminal domain

RNA

NR_160872.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC138221

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000081.7 Reference GRCm39 C57BL/6J

Range

98436570..98468340 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036159107.1 → XP_036015000.1 cyclin-T1 isoform X1

Conserved Domains (2) summary

cd20595
Location:10 → 147

CYCLIN_CCNT1_rpt1; first cyclin box found in cyclin-T1 (CCNT1)

cl40454
Location:151 → 235

CYCLIN_SF; Cyclin box fold superfamily