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    Cald1 caldesmon 1 [ Mus musculus (house mouse) ]

    Gene ID: 109624, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Cald1provided by MGI
    Official Full Name
    caldesmon 1provided by MGI
    Primary source
    MGI:MGI:88250
    See related
    Ensembl:ENSMUSG00000029761 AllianceGenome:MGI:88250
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    caldesmon; 4833423D12Rik; C920027I18Rik
    Summary
    Predicted to enable actin binding activity and myosin binding activity. Predicted to be involved in actin filament bundle assembly and angiogenesis. Predicted to act upstream of or within regulation of smooth muscle contraction. Located in actin cap and membrane. Is expressed in early conceptus; intestine smooth muscle circular layer; oocyte; and retina. Orthologous to human CALD1 (caldesmon 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in bladder adult (RPKM 210.7), placenta adult (RPKM 27.0) and 5 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    6 B1; 6 15.07 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (34575433..34752404)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (34598495..34775469)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 52898 Neighboring gene STARR-seq mESC enhancer starr_15540 Neighboring gene predicted gene, 32942 Neighboring gene STARR-seq mESC enhancer starr_15541 Neighboring gene predicted gene 13861 Neighboring gene STARR-seq mESC enhancer starr_15542 Neighboring gene predicted gene, 38787 Neighboring gene ribosomal protein L7A pseudogene Neighboring gene ATP/GTP binding protein-like 3 Neighboring gene predicted gene, 46957

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Caldesmon ablation in mice causes umbilical herniation and alters contractility of fetal urinary bladder smooth muscle. Pütz S, et al. J Gen Physiol, 2021 Jul 5. PMID 34115104, Free PMC Article
    2. Amino acid mutations in the caldesmon COOH-terminal functional domain increase force generation in bladder smooth muscle. Deng M, et al. Am J Physiol Renal Physiol, 2013 Nov 15. PMID 23986516, Free PMC Article
    3. Ablation of smooth muscle caldesmon affects the relaxation kinetics of arterial muscle. Guo H, et al. Pflugers Arch, 2013 Feb. PMID 23149489, Free PMC Article
    4. Specific disruption of smooth muscle caldesmon expression in mice. Guo H, et al. Biochem Biophys Res Commun, 2005 May 20. PMID 15823561
    5. TGFβ1-induced expression of caldesmon mediates epithelial-mesenchymal transition. Nalluri SM, et al. Cytoskeleton (Hoboken), 2018 May. PMID 29466836

    See all (49) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Caldesmon ablation in mice causes umbilical herniation and alters contractility of fetal urinary bladder smooth muscle.
      Title: Caldesmon ablation in mice causes umbilical herniation and alters contractility of fetal urinary bladder smooth muscle.
    2. TGFbeta1-induced expression of caldesmon mediates epithelial-mesenchymal transition.
      Title: TGFβ1-induced expression of caldesmon mediates epithelial-mesenchymal transition.
    3. Silencing of Sox4 decreased not only CaD protein synthesis but also myoblast fusion in C2C12 cells and myofibril formation in mouse embryonic muscle. Overexpression of CaD in Sox4-silenced C2C12 cells rescued the differentiation process.
      Title: Sox4-mediated caldesmon expression facilitates differentiation of skeletal myoblasts.
    4. Caldesmon-deficient mouse arterial muscles relax more slowly than wild-type tissues.
      Title: Ablation of smooth muscle caldesmon affects the relaxation kinetics of arterial muscle.
    5. distribution of the actin-binding protein caldesmon in spleen and lymph nodes of mice and rats
      Title: The actin-binding protein caldesmon is in spleen and lymph nodes predominately expressed by smooth-muscle cells, reticular cells, and follicular dendritic cells.
    6. Caldesmon binds and stabilizes actin filaments, as well as regulates actin-myosin interaction in a calcium (Ca2+)/calmodulin (CaM)- and/or phosphorylation-dependent manner. (Review)
      Title: Diversification of caldesmon-linked actin cytoskeleton in cell motility.
    7. This study reports a novel molecular mechanism (caldesmon), as well as a structural basis (podosomes/rosettes), to show how p53 can act as an anti-motility/invasion/metastasis agent.
      Title: p53 suppresses Src-induced podosome and rosette formation and cellular invasiveness through the upregulation of caldesmon.
    8. K-cyclin expression modulates the activity of caldesmon and through this the microfilament functions in cells
      Title: Regulation of microfilament organization by Kaposi sarcoma-associated herpes virus-cyclin.CDK6 phosphorylation of caldesmon.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC30319

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables actin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables actin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables actin binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables myosin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin filament bundle assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in actin filament bundle assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in angiogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of smooth muscle contraction TAS
    Traceable Author Statement
    more info
    		 PubMed 
    NOT involved_in response to transforming growth factor beta IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in actin cap IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in actin filament ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in dendritic spine ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in postsynapse ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    caldesmon

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001347100.1 → NP_001334029.1  caldesmon isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC102668, AC153627
      Consensus CDS
      CCDS85029.1
      UniProtKB/TrEMBL
      E9Q0M9, E9QA16
      Related
      ENSMUSP00000110678.2, ENSMUST00000115026.8
      Conserved Domains (1) summary
      pfam02029
      Location:53 → 523
      Caldesmon

    2. NM_145575.3 → NP_663550.1  caldesmon isoform 2

      See identical proteins and their annotated locations for NP_663550.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and has multiple coding region differences, compared to variant 1. These differences cause translation initiation at a downstream AUG and result in an isoform (2) with a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AC153627, AK160593, BQ769983, BY308240, CX568419
      Consensus CDS
      CCDS39456.1
      UniProtKB/TrEMBL
      D3Z6I7, Q8VCQ8
      Related
      ENSMUSP00000110673.2, ENSMUST00000115021.8
      Conserved Domains (1) summary
      pfam02029
      Location:255 → 517
      Caldesmon; Caldesmon

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      34575433..34752404
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006505348.5 → XP_006505411.1  caldesmon isoform X7

      See identical proteins and their annotated locations for XP_006505411.1

      UniProtKB/TrEMBL
      E9QA15
      Related
      ENSMUSP00000110679.2, ENSMUST00000115027.8
      Conserved Domains (1) summary
      pfam02029
      Location:363 → 759
      Caldesmon

    2. XM_006505352.4 → XP_006505415.1  caldesmon isoform X5

      UniProtKB/TrEMBL
      E9Q0M9
      Conserved Domains (1) summary
      pfam02029
      Location:53 → 523
      Caldesmon

    3. XM_036165745.1 → XP_036021638.1  caldesmon isoform X5

      UniProtKB/TrEMBL
      E9Q0M9
      Conserved Domains (1) summary
      pfam02029
      Location:53 → 523
      Caldesmon

    4. XM_030255093.1 → XP_030110953.1  caldesmon isoform X6

      UniProtKB/TrEMBL
      E9Q0M9, E9QA16
      Conserved Domains (1) summary
      pfam02029
      Location:53 → 523
      Caldesmon

    5. XM_006505345.5 → XP_006505408.3  caldesmon isoform X1

      UniProtKB/TrEMBL
      E9QA15
      Conserved Domains (1) summary
      pfam02029
      Location:434 → 830
      Caldesmon

    6. XM_006505346.4 → XP_006505409.3  caldesmon isoform X2

      UniProtKB/TrEMBL
      E9QA15
      Conserved Domains (1) summary
      pfam02029
      Location:434 → 830
      Caldesmon

    7. XM_030255090.2 → XP_030110950.2  caldesmon isoform X3

      UniProtKB/TrEMBL
      E9QA15
      Conserved Domains (1) summary
      pfam02029
      Location:434 → 802
      Caldesmon

    8. XM_006505351.4 → XP_006505414.3  caldesmon isoform X4

      UniProtKB/TrEMBL
      D3Z6I7
      Conserved Domains (1) summary
      pfam02029
      Location:124 → 594
      Caldesmon

    RNA

    1. XR_004942901.1 RNA Sequence

    2. XR_004942902.1 RNA Sequence

    3. XR_004942906.1 RNA Sequence

    4. XR_004942907.1 RNA Sequence

    5. XR_004942903.1 RNA Sequence

    6. XR_004942899.1 RNA Sequence

    7. XR_004942898.1 RNA Sequence

    8. XR_004942900.1 RNA Sequence

    9. XR_004942904.1 RNA Sequence

    10. XR_004942905.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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