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    Cdh22 cadherin 22 [ Mus musculus (house mouse) ]

    Gene ID: 104010, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Cdh22provided by MGI
    Official Full Name
    cadherin 22provided by MGI
    Primary source
    MGI:MGI:1341843
    See related
    Ensembl:ENSMUSG00000053166 AllianceGenome:MGI:1341843
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable cadherin binding activity and calcium ion binding activity. Predicted to be involved in calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules; cell morphogenesis; and cell-cell junction organization. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Predicted to be part of catenin complex. Predicted to be active in adherens junction. Is expressed in several structures, including central nervous system; heart; limb; limb bud; and retina. Orthologous to human CDH22 (cadherin 22). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in cerebellum adult (RPKM 8.6), frontal lobe adult (RPKM 5.4) and 8 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    2 H3; 2 85.43 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (164953421..165076892, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (165111501..165234924, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700025C18 gene Neighboring gene STARR-seq mESC enhancer starr_06347 Neighboring gene predicted gene, 36690 Neighboring gene predicted gene, 36803 Neighboring gene predicted gene, 36748 Neighboring gene predicted gene, 25569 Neighboring gene solute carrier family 35, member C2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Transposition-based method for the rapid generation of gene-targeting vectors to produce Cre/Flp-modifiable conditional knock-out mice. Turakainen H, et al. PLoS One, 2009. PMID 19194496, Free PMC Article
    2. AKT3 Is a Pivotal Molecule of Cadherin-22 and GDNF Family Receptor-α1 Signal Pathways Regulating Self-Renewal in Female Germline Stem Cells. Zhang X, et al. Stem Cells, 2019 Aug. PMID 31041846
    3. Cadherin 22 participates in the self-renewal of mouse female germ line stem cells via interaction with JAK2 and β-catenin. Zhang X, et al. Cell Mol Life Sci, 2018 Apr. PMID 29063123
    4. Molecular cloning and characterization of a newly identified member of the cadherin family, PB-cadherin. Sugimoto K, et al. J Biol Chem, 1996 May 10. PMID 8626716
    5. Expression of a novel type of classic cadherin, PB-cadherin in developing brain and limb buds. Kitajima K, et al. Dev Dyn, 1999 Jul. PMID 10398531

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. glial cell line-derived neurotrophic factor (GDNF) was identified as an essential factor for FGSCs self-renewal with a more complicated mechanism: GDNF-GFRA1 activates AKT3 via PI3K or Src family kinase (SFK), and SFK upregulates its target genes, Bcl6b, Etv5, and Lhx1, to promote self-renewal of Female germline stem cells.
      Title: AKT3 Is a Pivotal Molecule of Cadherin-22 and GDNF Family Receptor-α1 Signal Pathways Regulating Self-Renewal in Female Germline Stem Cells.
    2. Janus kinase 2 protein (JAK2) and beta-catenin were found to interact with cadherin-22 (Cdh22) and involved in CDH22 signaling in female germ line stem cells (FGSCs).
      Title: Cadherin 22 participates in the self-renewal of mouse female germ line stem cells via interaction with JAK2 and β-catenin.
    3. Results describe the expression of Cdh22 in developing mouse brain and compare it to expression of related family members.
      Title: Analysis of Cdh22 expression and function in the developing mouse brain.
    4. spatio-temporal mRNA distribution pattern of Cdh12 and Cdh22 during CNS development; demonstrate presence of Cdh12 and Cdh22 mRNA in both excitatory and inhibitory neurons in adult CNS including cerebellum, neocortex, hippocampus and subcortical nuclei
      Title: Expression of two type II cadherins, Cdh12 and Cdh22 in the developing and adult mouse brain.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (2)  1 citation
    • Endonuclease-mediated (2) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables beta-catenin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cadherin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in adherens junction organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell-cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell-cell adhesion mediated by cadherin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell-cell junction assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in homophilic cell adhesion via plasma membrane adhesion molecules IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in multicellular organism development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in adherens junction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of catenin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    cadherin-22
    Names
    PB-cadherin
    pituitary and brain cadherin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_174988.3 → NP_778153.2  cadherin-22 precursor

      See identical proteins and their annotated locations for NP_778153.2

      Status: VALIDATED

      Source sequence(s)
      AK140248, AL591411, BC112407
      Consensus CDS
      CCDS17073.1
      UniProtKB/Swiss-Prot
      I7HIP9, Q9WTP5
      Related
      ENSMUSP00000066864.7, ENSMUST00000065438.13
      Conserved Domains (2) summary
      cd11304
      Location:398 → 492
      Cadherin_repeat; Cadherin tandem repeat domain
      pfam01049
      Location:645 → 804
      Cadherin_C; Cadherin cytoplasmic region

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      164953421..165076892 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036157158.1 → XP_036013051.1  cadherin-22 isoform X2

      Conserved Domains (2) summary
      cd11304
      Location:276 → 370
      Cadherin_repeat; Cadherin tandem repeat domain
      pfam01049
      Location:523 → 682
      Cadherin_C; Cadherin cytoplasmic region

    2. XM_006498536.5 → XP_006498599.1  cadherin-22 isoform X4

      Conserved Domains (3) summary
      cd11304
      Location:95 → 193
      Cadherin_repeat; Cadherin tandem repeat domain
      smart00112
      Location:22 → 90
      CA; Cadherin repeats
      pfam01049
      Location:241 → 400
      Cadherin_C; Cadherin cytoplasmic region

    3. XM_036157156.1 → XP_036013049.1  cadherin-22 isoform X1

      UniProtKB/Swiss-Prot
      I7HIP9, Q9WTP5
      Conserved Domains (2) summary
      cd11304
      Location:398 → 492
      Cadherin_repeat; Cadherin tandem repeat domain
      pfam01049
      Location:645 → 804
      Cadherin_C; Cadherin cytoplasmic region

    4. XM_006498534.4 → XP_006498597.1  cadherin-22 isoform X2

      Conserved Domains (2) summary
      cd11304
      Location:276 → 370
      Cadherin_repeat; Cadherin tandem repeat domain
      pfam01049
      Location:523 → 682
      Cadherin_C; Cadherin cytoplasmic region

    5. XM_030246473.2 → XP_030102333.1  cadherin-22 isoform X3

      Conserved Domains (1) summary
      cd11304
      Location:398 → 492
      Cadherin_repeat; Cadherin tandem repeat domain

    RNA

    1. XR_003949827.2 RNA Sequence

    2. XR_004937403.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9WTP5.2 GenPept UniProtKB/Swiss-Prot:Q9WTP5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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